Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems
Scientific Reports
Original publication · Original publication
Attributed extracts from the research record
“The results revealed a significant effect in the interaction between OXTR rs53576 genotype and maternal postpartum depression on externalising problems in children with AA genotype ( β = 0.136, 95% CI 0.032 to 0.240), but not in those with GG/GA genotype.”
“This indicates that an interaction of vulnerable genotypes (i.e., A allele of OXTR rs53576) with an environmental burden (i.e. maternal postpartum depression) may be one of the potential elements that predisposes the infant to developing behavioural problems early in life.”
“Hence, special attention needs to be paid to children exposed to environmental risks such as maternal postpartum depression, to facilitate the provision of appropriate care.”
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- assessment
- Not recorded
- trust Factor
- score
- Not recorded
- scope
- Paper
- status
- unassessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- false
- basis
- Publication-specific design or publication status remains unconfirmed.
- sources
https://www.nature.com/articles/s41598-019-44175-6
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
- key
- sound:xxx
- title
- OXTR variation and psychological resources
- collection
- sound
- trust Score
- 1
- key
- general:sound-xxx
- title
- OXTR variation and psychological resources
- collection
- general
- trust Score
- 1
Citation snapshot and identifiers
- id
- src-f509442c9ca1
- doi
- 10.1038/s41598-019-44175-6
- pmid
- Not recorded
- citation Snapshot
- Not recorded
- citations By Collection
- sound
- 7
- general
- 7
Complete approved library record
- id
- src-f509442c9ca1
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems
- journal
- Scientific Reports
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- Not recorded
- authors
- design
- kind
- Source record
- identity Conflict
- Not recorded
- doi
- 10.1038/s41598-019-44175-6
- urls
https://www.nature.com/articles/s41598-019-44175-6 · https://doi.org/10.1038/s41598-019-44175-6
- collections
sound · general
- categories
Genetics & genomics · Molecular biomarkers · Clinical & self-report
- targets
OXTR · OXT
- priority
- 0
- quotes
“The results revealed a significant effect in the interaction between OXTR rs53576 genotype and maternal postpartum depression on externalising problems in children with AA genotype ( β = 0.136, 95% CI 0.032 to 0.240), but not in those with GG/GA genotype.” · “This indicates that an interaction of vulnerable genotypes (i.e., A allele of OXTR rs53576) with an environmental burden (i.e. maternal postpartum depression) may be one of the potential elements that predisposes the infant to developing behavioural problems early in life.” · “Hence, special attention needs to be paid to children exposed to environmental risks such as maternal postpartum depression, to facilitate the provision of appropriate care.”
- summary
- limitation
- citation Count
- 7
- paper Trust Assessment
- score
- Not recorded
- scope
- Paper
- status
- unassessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- false
- basis
- Publication-specific design or publication status remains unconfirmed.
- sources
https://www.nature.com/articles/s41598-019-44175-6
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- 7
- general
- 7
- topics
- key
- sound:xxx
- title
- OXTR variation and psychological resources
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- 1
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- title
- OXTR variation and psychological resources
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- 1
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- scientificreports
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- Scientific Reports
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- record Id
- src-f509442c9ca1
- title
- Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems
- journal
- Scientific Reports
- year
- Not recorded
- authors
- design
- urls
https://www.nature.com/articles/s41598-019-44175-6 · https://doi.org/10.1038/s41598-019-44175-6
- quotes
- text
- “The results revealed a significant effect in the interaction between OXTR rs53576 genotype and maternal postpartum depression on externalising problems in children with AA genotype ( β = 0.136, 95% CI 0.032 to 0.240), but not in those with GG/GA genotype.”
- emphasis
- false
- text
- “This indicates that an interaction of vulnerable genotypes (i.e., A allele of OXTR rs53576) with an environmental burden (i.e. maternal postpartum depression) may be one of the potential elements that predisposes the infant to developing behavioural problems early in life.”
- emphasis
- false
- text
- “Hence, special attention needs to be paid to children exposed to environmental risks such as maternal postpartum depression, to facilitate the provision of appropriate care.”
- emphasis
- false
- citation Count
- 7
- source Pages
123
- targets
OXTR · OXT
- categories
Genetics & genomics · Molecular biomarkers · Clinical & self-report
- doi
- 10.1038/s41598-019-44175-6
- pmid
- Not recorded
- paper Trust Assessment
- score
- Not recorded
- scope
- Paper
- status
- unassessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- false
- basis
- Publication-specific design or publication status remains unconfirmed.
- sources
https://www.nature.com/articles/s41598-019-44175-6
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- sound
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- OXTR variation and psychological resources
- trust Score
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- record Id
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- title
- Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems
- journal
- Scientific Reports
- year
- Not recorded
- authors
- design
- urls
https://www.nature.com/articles/s41598-019-44175-6 · https://doi.org/10.1038/s41598-019-44175-6
- quotes
- text
- “The results revealed a significant effect in the interaction between OXTR rs53576 genotype and maternal postpartum depression on externalising problems in children with AA genotype ( β = 0.136, 95% CI 0.032 to 0.240), but not in those with GG/GA genotype.”
- emphasis
- false
- text
- “This indicates that an interaction of vulnerable genotypes (i.e., A allele of OXTR rs53576) with an environmental burden (i.e. maternal postpartum depression) may be one of the potential elements that predisposes the infant to developing behavioural problems early in life.”
- emphasis
- false
- text
- “Hence, special attention needs to be paid to children exposed to environmental risks such as maternal postpartum depression, to facilitate the provision of appropriate care.”
- emphasis
- false
- citation Count
- 7
- source Pages
123
- targets
OXTR · OXT
- categories
Genetics & genomics · Molecular biomarkers · Clinical & self-report
- doi
- 10.1038/s41598-019-44175-6
- pmid
- Not recorded
- paper Trust Assessment
- score
- Not recorded
- scope
- Paper
- status
- unassessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- false
- basis
- Publication-specific design or publication status remains unconfirmed.
- sources
https://www.nature.com/articles/s41598-019-44175-6
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 1
- topic Id
- sound-xxx
- topic Title
- OXTR variation and psychological resources
- trust Score
- 1
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- depression
- evidence
- field
- title
- text
- Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems
- matched Text
- depression
- conditions
depression
- topic Trust Scores
1
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6531431/fullTextXML
- pmcid
- PMC6531431
- rights
- license
- http://creativecommons.org/licenses/by/4.0/
- statement
© The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ .
- sha256
- 7902a4627967ed8c9681a7c053de46cd95de8c4ec982dd71116e6847e595c5b6
- checked At
- 2026-10-24