Universal Informatics · Research reading room

Rapid Systematic Review: The Impact of Social Isolation and Loneliness on the Mental Health of Children and Adolescents in the Context of COVID-19.

Loades ME, Chatburn E, Higson-Sweeney N, Reynolds S, Shafran R, Brigden A, Linney C, McManus MN, Borwick C, Crawley E. · Journal of the American Academy of Child and Adolescent Psychiatry · 2020 · Review / synthesis

Original publication · Original publication · Original publication · Original publication · Original publication

Recorded summary

Loneliness and isolation were associated with depression and sometimes anxiety; intervention evidence was sparse and mixed.

Recorded limitations

Only 20% duplicate screening/extraction, high risk of bias, mostly pre-pandemic observational evidence; isolation and loneliness are not identical.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Review / synthesis
assessment
category
review
is Randomized Controlled Trial
false
peer Reviewed
true
basis
Rapid systematic review
masking Roles
Not applicable or not established from inspected methods; no masking inferred
sources

https://pubmed.ncbi.nlm.nih.gov/32504808/ · https://doi.org/10.1016/j.jaac.2020.05.009 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7267797/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7267797/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.jaac.2020.05.009

review Scope
selected-methods
trust Factor
score
1
display Crosses
1
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
false
peer Reviewed
true
blinding
not-applicable
masking Roles
Not applicable or not established from inspected methods; no masking inferred
basis
Rapid systematic review
sources

https://pubmed.ncbi.nlm.nih.gov/32504808/ · https://doi.org/10.1016/j.jaac.2020.05.009 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7267797/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7267797/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.jaac.2020.05.009

assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
not-applicable
score
Not recorded
evidence
evidence Type
Review / synthesis
intervention
Not applicable or not established from inspected sections
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
83 reports, 80 studies; mostly observational
population
age
Children/adolescents including young adults; healthy-sample mean 15.3
age Fit
younger-overlap
sample
83 reports, 80 studies; mostly observational
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
publication-32504808
trial Registries
None recorded
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Respond to opportunities for connection while evaluating benefits rather than claiming causal protection from the review. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
qualified
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Not applicable or not established from inspected methods; no masking inferred
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs

https://pubmed.ncbi.nlm.nih.gov/32504808/ · https://doi.org/10.1016/j.jaac.2020.05.009 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7267797/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7267797/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.jaac.2020.05.009

retrieved At
2026-11-02
Topics and recorded topic scores
  1. key
    language:universal-mind-mobile-lab
    title
    Universal Mind Mobile Lab · Direct response and inspired by
    collection
    language
    trust Score
    3
  2. key
    language:youth-access-connection
    title
    Youth access, digital support and connection
    collection
    language
    trust Score
    3
Citation snapshot and identifiers
id
youth-pmid-32504808
doi
10.1016/j.jaac.2020.05.009
pmid
32504808
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
citations By Collection
language
Not recorded
Complete approved library record
lab Relevance
relationship
direct-response
implication
Respond to opportunities for connection while evaluating benefits rather than claiming causal protection from the review.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
institutions
None recorded
institution Evidence
None recorded
research Topics

Youth needs / digital / access

publication Status
pmid
32504808
checked At
2026-11-02T01:32:42.286670+00:00
pub Types

Systematic Review · review-article · Journal Article

indexed Notices
  1. source
    MED
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    32890669
    reference
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    type
    Comment in
    order In
    1
crossref Updates
None recorded
notice Records
  1. pmid
    32890669
    type
    Comment in
    title
    School Closures and Social Anxiety During the COVID-19 Pandemic.
    doi
    10.1016/j.jaac.2020.08.436
    pmcid
    PMC7467010
    url
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scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
randomized Study Unit Id
Not recorded
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-3840cefa07ed
source Content Hash
3840cefa07ed77e8cb996624927189aba590df3b26d69123a77fcf992e834667
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs

https://pubmed.ncbi.nlm.nih.gov/32504808/ · https://doi.org/10.1016/j.jaac.2020.05.009 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7267797/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7267797/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.jaac.2020.05.009

retrieved At
2026-11-02
study Family Id
publication-32504808
approaches

Youth needs / digital / access

id
youth-pmid-32504808
aliases
None recorded
title
Rapid Systematic Review: The Impact of Social Isolation and Loneliness on the Mental Health of Children and Adolescents in the Context of COVID-19.
journal
Journal of the American Academy of Child and Adolescent Psychiatry
neurotransmitters
None recorded
year
2020
authors
Loades ME, Chatburn E, Higson-Sweeney N, Reynolds S, Shafran R, Brigden A, Linney C, McManus MN, Borwick C, Crawley E.
design
Review / synthesis
kind
Review
identity Conflict
Not recorded
doi
10.1016/j.jaac.2020.05.009
pmid
32504808
urls

https://doi.org/10.1016/j.jaac.2020.05.009 · https://pubmed.ncbi.nlm.nih.gov/32504808/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC7267797/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7267797/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.jaac.2020.05.009

collections

language

categories

Methods & context

targets
None recorded
priority
1
quotes
None recorded
summary
Loneliness and isolation were associated with depression and sometimes anxiety; intervention evidence was sparse and mixed.
limitation
Only 20% duplicate screening/extraction, high risk of bias, mostly pre-pandemic observational evidence; isolation and loneliness are not identical.
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
study Design Assessment
category
review
is Randomized Controlled Trial
false
peer Reviewed
true
basis
Rapid systematic review
masking Roles
Not applicable or not established from inspected methods; no masking inferred
sources

https://pubmed.ncbi.nlm.nih.gov/32504808/ · https://doi.org/10.1016/j.jaac.2020.05.009 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7267797/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7267797/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.jaac.2020.05.009

review Scope
selected-methods
paper Trust Assessment
score
1
display Crosses
1
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
false
peer Reviewed
true
blinding
not-applicable
masking Roles
Not applicable or not established from inspected methods; no masking inferred
basis
Rapid systematic review
sources

https://pubmed.ncbi.nlm.nih.gov/32504808/ · https://doi.org/10.1016/j.jaac.2020.05.009 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7267797/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7267797/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.jaac.2020.05.009

assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
citations By Collection
language
Not recorded
topics
  1. key
    language:universal-mind-mobile-lab
    title
    Universal Mind Mobile Lab · Direct response and inspired by
    collection
    language
    trust Score
    3
  2. key
    language:youth-access-connection
    title
    Youth access, digital support and connection
    collection
    language
    trust Score
    3
journal Key
journaloftheamericanacademyofchildandadolescentpsychiatry
journal Label
Journal of the American Academy of Child and Adolescent Psychiatry
chapter Entries
  1. id
    language-universal-mind-mobile-lab-youth-pmid-32504808
    aliases
    None recorded
    title
    Rapid Systematic Review: The Impact of Social Isolation and Loneliness on the Mental Health of Children and Adolescents in the Context of COVID-19.
    authors
    Loades ME, Chatburn E, Higson-Sweeney N, Reynolds S, Shafran R, Brigden A, Linney C, McManus MN, Borwick C, Crawley E.
    year
    2020
    journal
    Journal of the American Academy of Child and Adolescent Psychiatry
    doi
    10.1016/j.jaac.2020.05.009
    pmid
    32504808
    urls

    https://doi.org/10.1016/j.jaac.2020.05.009 · https://pubmed.ncbi.nlm.nih.gov/32504808/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC7267797/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7267797/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.jaac.2020.05.009

    collections

    language

    categories

    Methods & context

    targets
    None recorded
    neurotransmitters
    None recorded
    conditions

    anxiety · depression

    condition Evidence
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      evidence
      1. field
        findings
        text
        Loneliness and isolation were associated with depression and sometimes anxiety; intervention evidence was sparse and mixed.
        matched Text
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      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    2. id
      depression
      evidence
      1. field
        findings
        text
        Loneliness and isolation were associated with depression and sometimes anxiety; intervention evidence was sparse and mixed.
        matched Text
        depression
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    age Groups

    children · adolescents · youth · adults

    age Population
    record Id
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    collections

    language

    groups

    children · adolescents · youth · adults

    reported Ages
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    youth Scope
    focus
    youth Source Note
    The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
    age Fit
    younger-overlap
    source URL
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    basis Type
    selected-methods-ai-editorial-assessment
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    Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
    community Matches
    None recorded
    kind
    Review
    design
    Review / synthesis
    origin
    approved-youth-20261102
    priority
    1
    quotes
    None recorded
    finding
    Loneliness and isolation were associated with depression and sometimes anxiety; intervention evidence was sparse and mixed.
    summary
    Loneliness and isolation were associated with depression and sometimes anxiety; intervention evidence was sparse and mixed.
    limitation
    Only 20% duplicate screening/extraction, high risk of bias, mostly pre-pandemic observational evidence; isolation and loneliness are not identical.
    evidence
    evidence Type
    Review / synthesis
    intervention
    Not applicable or not established from inspected sections
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    sample
    83 reports, 80 studies; mostly observational
    population
    age
    Children/adolescents including young adults; healthy-sample mean 15.3
    age Fit
    younger-overlap
    sample
    83 reports, 80 studies; mostly observational
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    measurement
    Specific outcomes are reported in the finding and retained appraisal.
    trial Id
    publication-32504808
    trial Registries
    None recorded
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    Identifiers explicitly reported in article abstract; other registrations remain unverified
    relationship Note
    Respond to opportunities for connection while evaluating benefits rather than claiming causal protection from the review. Component evidence does not establish efficacy of the combined Universal Mind lab model.
    measured Genes
    None recorded
    pathways
    None recorded
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
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    jadad Score
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    Not applicable or not established from inspected methods; no masking inferred
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
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    Paper
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    false
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    true
    blinding
    not-applicable
    masking Roles
    Not applicable or not established from inspected methods; no masking inferred
    basis
    Rapid systematic review
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    https://pubmed.ncbi.nlm.nih.gov/32504808/ · https://doi.org/10.1016/j.jaac.2020.05.009 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7267797/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7267797/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.jaac.2020.05.009

    assessed At
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    false
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    AI source-based design assessment; human content sign-off is recorded separately.
    jadad
    status
    not-applicable
    score
    Not recorded
    citation Count
    Not recorded
    citation Snapshot
    count
    Not recorded
    source
    Not recorded
    retrieved At
    Not recorded
    status
    not-assessed
    publication Approval
    status
    approved-for-publication
    approved By
    Ben Korbel
    approved At
    2026-11-02
    assessment
    AI assessed; human approved for publication
    scope
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    retrieved At
    2026-11-02
    study Family Id
    publication-32504808
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    Not recorded
    institutions
    None recorded
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    None recorded
    research Topics

    Youth needs / digital / access

    lab Relevance
    relationship
    direct-response
    implication
    Respond to opportunities for connection while evaluating benefits rather than claiming causal protection from the review.
    transfer Limit
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    pmid
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      title
      School Closures and Social Anxiety During the COVID-19 Pandemic.
      doi
      10.1016/j.jaac.2020.08.436
      pmcid
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    Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
    approaches

    Youth needs / digital / access

    record Id
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    source Pages
    None recorded
    assessment Record
    id
    youth-pmid-32504808
    title
    Rapid Systematic Review: The Impact of Social Isolation and Loneliness on the Mental Health of Children and Adolescents in the Context of COVID-19.
    authors
    Loades ME, Chatburn E, Higson-Sweeney N, Reynolds S, Shafran R, Brigden A, Linney C, McManus MN, Borwick C, Crawley E.
    year
    2020
    journal
    Journal of the American Academy of Child and Adolescent Psychiatry
    doi
    10.1016/j.jaac.2020.05.009
    pmid
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    pmcid
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    trial Registries
    None recorded
    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    collection
    youth-20261102
    topics

    Youth needs / digital / access

    institutions
    None recorded
    institution Evidence
    None recorded
    publication Type

    Systematic Review · review-article · Journal Article

    study Family Id
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    randomized Study Unit Id
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    existing Repository Matches
    None recorded
    population
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    Children/adolescents including young adults; healthy-sample mean 15.3
    age Fit
    younger-overlap
    sample
    83 reports, 80 studies; mostly observational
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
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    Not applicable or not established from inspected sections
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    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
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    Rapid systematic review
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    randomization Methods Inspected
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    masking
    Not applicable or not established from inspected methods; no masking inferred
    double Blinding Verified
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    proposed Crosses
    1
    approved Crosses
    Not recorded
    findings
    Loneliness and isolation were associated with depression and sometimes anxiety; intervention evidence was sparse and mixed.
    limitations
    Only 20% duplicate screening/extraction, high risk of bias, mostly pre-pandemic observational evidence; isolation and loneliness are not identical.
    harms And Attrition
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    lab Relevance
    relationship
    direct-response
    implication
    Respond to opportunities for connection while evaluating benefits rather than claiming causal protection from the review.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
    source Access
    scope
    selected-methods
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    true
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    true
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    pub Types

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    indexed Notices
    1. source
      MED
      id
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    title
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false
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retrieved At
2026-11-02
jadad
status
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score
Not recorded
condition Evidence
  1. id
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conditions

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topic Trust Scores

3

full Text
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retrieval Available
false

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