The Horyzons project: a randomized controlled trial of a novel online social therapy to maintain treatment effects from specialist first-episode psychosis services.
Alvarez-Jimenez M, Koval P, Schmaal L, Bendall S, O'Sullivan S, Cagliarini D, D'Alfonso S, Rice S, Valentine L, Penn DL, Miles C, Russon P, Phillips J, McEnery C, Lederman R, Killackey E, Mihalopoulos C, Gonzalez-Blanch C, Gilbertson T, Lal S, Cotton SM, Herrman H, McGorry PD, Gleeson JFM. · World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021 · Randomized controlled trial report · single masked role verified
Original publication · Original publication · Original publication · Original publication
Recorded summary
Primary social functioning null: difference −0.29 (95% CI −4.20 to 3.63). Employment/education secondary odds favoured Horyzons (OR 5.55, wide CI 1.09–28.23); emergency visits lower; hospitalisation difference not significant.
Recorded limitations
Primary social-function outcome null; secondary vocational result imprecise. Dose associations are not randomised effects; specialist remission sample may have ceiling effects.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
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- masking Roles
- External statistician computer permuted blocks; secure concealed allocation; assessors and statisticians masked, replacement assessor if unblinded; participants know access.
- sources
https://pubmed.ncbi.nlm.nih.gov/34002511/ · https://doi.org/10.1002/wps.20858 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8129860/ · https://api.crossref.org/works/10.1002%2Fwps.20858 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8129860/
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- External statistician computer permuted blocks; secure concealed allocation; assessors and statisticians masked, replacement assessor if unblinded; participants know access.
- basis
- Reported single-blind randomised controlled trial
- sources
https://pubmed.ncbi.nlm.nih.gov/34002511/ · https://doi.org/10.1002/wps.20858 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8129860/ · https://api.crossref.org/works/10.1002%2Fwps.20858 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8129860/
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- evidence
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- Randomized controlled trial report · single masked role verified
- intervention
- 18-month moderated online therapy/social network with clinician, peer and vocational support after specialist psychosis care
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- sample
- 170; 86 Horyzons, 84 usual care
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- age
- 16–27; related economic paper mean 20.91
- age Fit
- mixed-overlap
- sample
- 170; 86 Horyzons, 84 usual care
- setting
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- community
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- measurement
- Specific outcomes are reported in the finding and retained appraisal.
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- None recorded
- registry Scope
- Identifiers explicitly reported in article abstract; other registrations remain unverified
- relationship Note
- Relevant model for continuity, peer and vocational support; preserve primary null result and specialist population limit. Component evidence does not establish efficacy of the combined Universal Mind lab model.
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- Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
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- Not recorded
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Complete approved library record
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- indexed Notices
- None recorded
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- None recorded
- notice Records
- None recorded
- scope
- Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
- notice Summary
- Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
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- approved-for-publication
- approved By
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- approved At
- 2026-11-02
- assessment
- AI assessed; human approved for publication
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- title
- The Horyzons project: a randomized controlled trial of a novel online social therapy to maintain treatment effects from specialist first-episode psychosis services.
- journal
- World psychiatry : official journal of the World Psychiatric Association (WPA)
- neurotransmitters
- None recorded
- year
- 2021
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- Alvarez-Jimenez M, Koval P, Schmaal L, Bendall S, O'Sullivan S, Cagliarini D, D'Alfonso S, Rice S, Valentine L, Penn DL, Miles C, Russon P, Phillips J, McEnery C, Lederman R, Killackey E, Mihalopoulos C, Gonzalez-Blanch C, Gilbertson T, Lal S, Cotton SM, Herrman H, McGorry PD, Gleeson JFM.
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- Primary social functioning null: difference −0.29 (95% CI −4.20 to 3.63). Employment/education secondary odds favoured Horyzons (OR 5.55, wide CI 1.09–28.23); emergency visits lower; hospitalisation difference not significant.
- limitation
- Primary social-function outcome null; secondary vocational result imprecise. Dose associations are not randomised effects; specialist remission sample may have ceiling effects.
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- title
- The Horyzons project: a randomized controlled trial of a novel online social therapy to maintain treatment effects from specialist first-episode psychosis services.
- authors
- Alvarez-Jimenez M, Koval P, Schmaal L, Bendall S, O'Sullivan S, Cagliarini D, D'Alfonso S, Rice S, Valentine L, Penn DL, Miles C, Russon P, Phillips J, McEnery C, Lederman R, Killackey E, Mihalopoulos C, Gonzalez-Blanch C, Gilbertson T, Lal S, Cotton SM, Herrman H, McGorry PD, Gleeson JFM.
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- summary
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- Relevant model for continuity, peer and vocational support; preserve primary null result and specialist population limit.
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- record Id
- youth-pmid-34002511
- source Pages
- None recorded
- assessment Record
- id
- youth-pmid-34002511
- title
- The Horyzons project: a randomized controlled trial of a novel online social therapy to maintain treatment effects from specialist first-episode psychosis services.
- authors
- Alvarez-Jimenez M, Koval P, Schmaal L, Bendall S, O'Sullivan S, Cagliarini D, D'Alfonso S, Rice S, Valentine L, Penn DL, Miles C, Russon P, Phillips J, McEnery C, Lederman R, Killackey E, Mihalopoulos C, Gonzalez-Blanch C, Gilbertson T, Lal S, Cotton SM, Herrman H, McGorry PD, Gleeson JFM.
- year
- 2021
- journal
- World psychiatry : official journal of the World Psychiatric Association (WPA)
- doi
- 10.1002/wps.20858
- pmid
- 34002511
- pmcid
- PMC8129860
- trial Registries
- None recorded
- registry Scope
- Identifiers explicitly reported in article abstract; other registrations remain unverified
- collection
- youth-20261102
- topics
Youth needs / digital / access
- institutions
Orygen
- institution Evidence
- institution
- Orygen
- basis
- Author affiliation in primary indexed metadata or publisher full text
- evidence
- Orygen, Parkville, VIC, Australia.
- publication Type
brief-report · Journal Article
- study Family Id
- horyzons-actrn12614000009617
- randomized Study Unit Id
- horyzons-actrn12614000009617
- existing Repository Matches
- None recorded
- population
- age
- 16–27; related economic paper mean 20.91
- age Fit
- mixed-overlap
- sample
- 170; 86 Horyzons, 84 usual care
- setting
- Not separately established; see population/intervention description
- community
- Not assigned
- intervention
- description And Dose
- 18-month moderated online therapy/social network with clinician, peer and vocational support after specialist psychosis care
- provider
- Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
- comparator
- See design/intervention description; otherwise unknown
- design
- description
- Reported single-blind randomised controlled trial
- category
- randomized-report
- randomization Methods Inspected
- true
- masking
- External statistician computer permuted blocks; secure concealed allocation; assessors and statisticians masked, replacement assessor if unblinded; participants know access.
- double Blinding Verified
- false
- proposed Crosses
- 2
- approved Crosses
- Not recorded
- findings
- Primary social functioning null: difference −0.29 (95% CI −4.20 to 3.63). Employment/education secondary odds favoured Horyzons (OR 5.55, wide CI 1.09–28.23); emergency visits lower; hospitalisation difference not significant.
- limitations
- Primary social-function outcome null; secondary vocational result imprecise. Dose associations are not randomised effects; specialist remission sample may have ceiling effects.
- harms And Attrition
- Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
- lab Relevance
- relationship
- inspired-by
- implication
- Relevant model for continuity, peer and vocational support; preserve primary null result and specialist population limit.
- transfer Limit
- Component evidence does not establish efficacy of the combined Universal Mind lab model.
- source Access
- scope
- selected-methods-web
- full Text Cached
- false
- methods Inspected
- true
- full Text Appraisal Claim
- false
- sources
- type
- primary bibliographic record
- url
- https://pubmed.ncbi.nlm.nih.gov/34002511/
- retrieved At
- 2026-11-02
- sha256
- 1795d7592d8b6240286676e022b9ce75243b63f15eabdfc4763fb18779d559d0
- hash Scope
- normalized Europe PMC core metadata snapshot
- type
- publisher DOI
- url
- https://doi.org/10.1002/wps.20858
- retrieved At
- 2026-11-02
- type
- PMC article
- url
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8129860/
- retrieved At
- 2026-11-02
- access
- Availability does not imply methods accessed
- type
- DOI-metadata
- url
- https://api.crossref.org/works/10.1002%2Fwps.20858
- retrieved At
- 2026-11-02T00:58:52.011621+00:00
- sha256
- aad70e92b33df2fe95a87364fca546a44fb3e23c28686189f9641c7f43b496a2
- type
- Selected web methods recovery
- url
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8129860/
- retrieved At
- 2026-11-02
- sha256
- b6668749b510606f16d2f0348b91ddd6a799808955d41a74afd169a60fb5d5c6
- hash Scope
- Saved web tool response containing method excerpts
- publication Status
- pmid
- 34002511
- checked At
- 2026-11-02T01:32:45.414524+00:00
- pub Types
brief-report · Journal Article
- indexed Notices
- None recorded
- crossref Updates
- None recorded
- notice Records
- None recorded
- scope
- Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
- notice Summary
- Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
- quality
- tier
- priority
- qualification
- Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
- formal Risk Of Bias Tool Applied
- false
- jadad Score
- Not recorded
- review Ready
- true
- hold Reason
- Not recorded
- duplicate Of
- Not recorded
- review
- status
- pending
- reviewer
- Not recorded
- approved At
- Not recorded
- decision Scope
- Ben reviews proposed content and release; full medical-paper reading is not required.
- provenance
- Discovered and appraised by AI; pending human content sign-off
- production Eligible
- false
- approved Retrieval Eligible
- false
- selected Corpus References
- None recorded
- reference Scope
- Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
- content Hash
- ad3e0a00d7640af39934685a689d8b238d45902d03f6f04eba759120a0098fbb
- revision
- r1-ad3e0a00d764
- archive Entries
- None recorded
- collection
- language
- chapter Number
- 6
- topic Id
- youth-access-connection
- topic Title
- Youth access, digital support and connection
- trust Score
- 3
- evidence
- evidence Type
- Randomized controlled trial report · single masked role verified
- intervention
- 18-month moderated online therapy/social network with clinician, peer and vocational support after specialist psychosis care
- provider
- Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
- comparator
- See design/intervention description; otherwise unknown
- sample
- 170; 86 Horyzons, 84 usual care
- population
- age
- 16–27; related economic paper mean 20.91
- age Fit
- mixed-overlap
- sample
- 170; 86 Horyzons, 84 usual care
- setting
- Not separately established; see population/intervention description
- community
- Not assigned
- measurement
- Specific outcomes are reported in the finding and retained appraisal.
- trial Id
- horyzons-actrn12614000009617
- trial Registries
- None recorded
- registry Scope
- Identifiers explicitly reported in article abstract; other registrations remain unverified
- relationship Note
- Relevant model for continuity, peer and vocational support; preserve primary null result and specialist population limit. Component evidence does not establish efficacy of the combined Universal Mind lab model.
- measured Genes
- None recorded
- pathways
- None recorded
- quality
- tier
- priority
- qualification
- Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
- formal Risk Of Bias Tool Applied
- false
- jadad Score
- Not recorded
- masking Roles
- External statistician computer permuted blocks; secure concealed allocation; assessors and statisticians masked, replacement assessor if unblinded; participants know access.
- harms And Attrition
- Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
- source Access
- scope
- selected-methods-web
- full Text Cached
- false
- methods Inspected
- true
- full Text Appraisal Claim
- false
- level
- selected-methods-web
- source URLs
https://pubmed.ncbi.nlm.nih.gov/34002511/ · https://doi.org/10.1002/wps.20858 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8129860/ · https://api.crossref.org/works/10.1002%2Fwps.20858 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8129860/
- retrieved At
- 2026-11-02
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- psychosis
- evidence
- field
- title
- text
- The Horyzons project: a randomized controlled trial of a novel online social therapy to maintain treatment effects from specialist first-episode psychosis services.
- matched Text
- psychosis
- scope
- Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
- conditions
psychosis
- topic Trust Scores
2 · 3
- full Text
- status
- not-indexed
- retrieval Available
- false