Universal Informatics · Research reading room

Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.

Dewa LH, Lawrance E, Roberts L, Brooks-Hall E, Ashrafian H, Fontana G, Aylin P. · Journal of medical Internet research · 2021 · Systematic review / meta-analysis

Original publication · Original publication · Original publication · Original publication · Original publication

Recorded summary

Quality connection involved rapport, common identity, being valued and receiving responses; anonymity/privacy could help, while negative interactions or disconnection could hinder.

Recorded limitations

Mostly uncontrolled/cross-sectional evidence and only 10% double-screening. Pooled symptom changes cannot isolate a causal social-connection effect; percentage-style abstract wording is not an individual clinical improvement rate.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Systematic review / meta-analysis
assessment
category
review
is Randomized Controlled Trial
false
peer Reviewed
true
basis
Systematic scoping review/meta-analysis
masking Roles
Not applicable or not established from inspected methods; no masking inferred
sources

https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

review Scope
selected-methods
trust Factor
score
1
display Crosses
1
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
false
peer Reviewed
true
blinding
not-applicable
masking Roles
Not applicable or not established from inspected methods; no masking inferred
basis
Systematic scoping review/meta-analysis
sources

https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
not-applicable
score
Not recorded
evidence
evidence Type
Systematic review / meta-analysis
intervention
Not applicable or not established from inspected sections
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
42 studies, 23319 participants; ten pooled
population
age
Target 14–24
age Fit
mixed-overlap
sample
42 studies, 23319 participants; ten pooled
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
publication-34927592
trial Registries
None recorded
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Design responsive, moderated community experiences and measure their quality, including exclusion and negative interactions. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
qualified
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Not applicable or not established from inspected methods; no masking inferred
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs

https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

retrieved At
2026-11-02
Topics and recorded topic scores
  1. key
    language:universal-mind-mobile-lab
    title
    Universal Mind Mobile Lab · Direct response and inspired by
    collection
    language
    trust Score
    3
  2. key
    language:youth-access-connection
    title
    Youth access, digital support and connection
    collection
    language
    trust Score
    3
Citation snapshot and identifiers
id
youth-pmid-34927592
doi
10.2196/26584
pmid
34927592
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
citations By Collection
language
Not recorded
Complete approved library record
lab Relevance
relationship
inspired-by
implication
Design responsive, moderated community experiences and measure their quality, including exclusion and negative interactions.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
institutions
None recorded
institution Evidence
None recorded
research Topics

Youth needs / digital / access

publication Status
pmid
34927592
checked At
2026-11-02T01:32:45.417697+00:00
pub Types

Meta-Analysis · Scoping Review · Research Support, Non-U.S. Gov't · review-article · Journal Article

indexed Notices
  1. source
    MED
    id
    35275072
    reference
    J Med Internet Res. 2022 Mar 11;24(3):e37440. doi: 10.2196/37440
    type
    Comment in
    order In
    1
  2. source
    MED
    id
    35275073
    reference
    J Med Internet Res. 2022 Mar 11;24(3):e36739. doi: 10.2196/36739
    type
    Comment in
    order In
    2
crossref Updates
None recorded
notice Records
  1. pmid
    35275072
    type
    Comment in
    title
    Authors' Reply to: Toward a Better Understanding of Quality Social Connections. Comment on "Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis".
    doi
    10.2196/37440
    pmcid
    PMC8956999
    url
    https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A35275072+AND+SRC%3AMED&format=json&resultType=core
    sha256
    dc0884d6ad860b0072ba468f1ece85f454115f6f746b55cc91a3f3d4873cb924
    retrieved At
    2026-11-02T01:32:45.417697+00:00
    fulltext URL
    https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8956999/fullTextXML
    fulltext SHA256
    0e5197c0afb973a1f1a15dd0323714f22d7dc328012f2f7084b565e999c62e11
  2. pmid
    35275073
    type
    Comment in
    title
    Toward a Better Understanding of Quality Social Connections. Comment on "Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis".
    doi
    10.2196/36739
    pmcid
    PMC8957003
    url
    https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A35275073+AND+SRC%3AMED&format=json&resultType=core
    sha256
    f429df2ff7bc0ee81f526f515ffd4c3f42271e5c2d9b63f0a23114d0c1ea0f1b
    retrieved At
    2026-11-02T01:32:45.417697+00:00
    fulltext URL
    https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8957003/fullTextXML
    fulltext SHA256
    cff20b09f689caeb884fefe88d057c0938b76227fb9900c02e71f0008b89ef9d
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Published comment questioned duplicate inclusion. Authors replied that the two reports had different designs/outcomes and neither entered the meta-analysis; both sides retained.
randomized Study Unit Id
Not recorded
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-9c34edc59e59
source Content Hash
9c34edc59e594664e64608aaae23197de4acb75e59222f91f6ba9dad9972be5c
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs

https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

retrieved At
2026-11-02
study Family Id
publication-34927592
approaches

Youth needs / digital / access

id
youth-pmid-34927592
aliases
None recorded
title
Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.
journal
Journal of medical Internet research
neurotransmitters
None recorded
year
2021
authors
Dewa LH, Lawrance E, Roberts L, Brooks-Hall E, Ashrafian H, Fontana G, Aylin P.
design
Systematic review / meta-analysis
kind
Review
identity Conflict
Not recorded
doi
10.2196/26584
pmid
34927592
urls

https://doi.org/10.2196/26584 · https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

collections

language

categories

Methods & context

targets
None recorded
priority
1
quotes
None recorded
summary
Quality connection involved rapport, common identity, being valued and receiving responses; anonymity/privacy could help, while negative interactions or disconnection could hinder.
limitation
Mostly uncontrolled/cross-sectional evidence and only 10% double-screening. Pooled symptom changes cannot isolate a causal social-connection effect; percentage-style abstract wording is not an individual clinical improvement rate.
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
study Design Assessment
category
review
is Randomized Controlled Trial
false
peer Reviewed
true
basis
Systematic scoping review/meta-analysis
masking Roles
Not applicable or not established from inspected methods; no masking inferred
sources

https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

review Scope
selected-methods
paper Trust Assessment
score
1
display Crosses
1
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
false
peer Reviewed
true
blinding
not-applicable
masking Roles
Not applicable or not established from inspected methods; no masking inferred
basis
Systematic scoping review/meta-analysis
sources

https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
citations By Collection
language
Not recorded
topics
  1. key
    language:universal-mind-mobile-lab
    title
    Universal Mind Mobile Lab · Direct response and inspired by
    collection
    language
    trust Score
    3
  2. key
    language:youth-access-connection
    title
    Youth access, digital support and connection
    collection
    language
    trust Score
    3
journal Key
journalofmedicalinternetresearch
journal Label
Journal of medical Internet research
chapter Entries
  1. id
    language-universal-mind-mobile-lab-youth-pmid-34927592
    aliases
    None recorded
    title
    Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.
    authors
    Dewa LH, Lawrance E, Roberts L, Brooks-Hall E, Ashrafian H, Fontana G, Aylin P.
    year
    2021
    journal
    Journal of medical Internet research
    doi
    10.2196/26584
    pmid
    34927592
    urls

    https://doi.org/10.2196/26584 · https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

    collections

    language

    categories

    Methods & context

    targets
    None recorded
    neurotransmitters
    None recorded
    conditions

    anxiety · depression

    condition Evidence
    1. id
      anxiety
      evidence
      1. field
        title
        text
        Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.
        matched Text
        Anxiety
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    2. id
      depression
      evidence
      1. field
        title
        text
        Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.
        matched Text
        Depression
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    age Groups

    adolescents · youth · adults

    age Population
    record Id
    youth-pmid-34927592
    collections

    language

    groups

    adolescents · youth · adults

    reported Ages
    Target 14–24
    youth Scope
    included
    youth Source Note
    The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
    age Fit
    mixed-overlap
    source URL
    https://pubmed.ncbi.nlm.nih.gov/34927592/
    basis Type
    selected-methods-ai-editorial-assessment
    classification Note
    Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
    community Matches
    None recorded
    kind
    Review
    design
    Systematic review / meta-analysis
    origin
    approved-youth-20261102
    priority
    1
    quotes
    None recorded
    finding
    Quality connection involved rapport, common identity, being valued and receiving responses; anonymity/privacy could help, while negative interactions or disconnection could hinder.
    summary
    Quality connection involved rapport, common identity, being valued and receiving responses; anonymity/privacy could help, while negative interactions or disconnection could hinder.
    limitation
    Mostly uncontrolled/cross-sectional evidence and only 10% double-screening. Pooled symptom changes cannot isolate a causal social-connection effect; percentage-style abstract wording is not an individual clinical improvement rate.
    evidence
    evidence Type
    Systematic review / meta-analysis
    intervention
    Not applicable or not established from inspected sections
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    sample
    42 studies, 23319 participants; ten pooled
    population
    age
    Target 14–24
    age Fit
    mixed-overlap
    sample
    42 studies, 23319 participants; ten pooled
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    measurement
    Specific outcomes are reported in the finding and retained appraisal.
    trial Id
    publication-34927592
    trial Registries
    None recorded
    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    relationship Note
    Design responsive, moderated community experiences and measure their quality, including exclusion and negative interactions. Component evidence does not establish efficacy of the combined Universal Mind lab model.
    measured Genes
    None recorded
    pathways
    None recorded
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
    false
    jadad Score
    Not recorded
    masking Roles
    Not applicable or not established from inspected methods; no masking inferred
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    level
    selected-methods
    source URLs

    https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

    retrieved At
    2026-11-02
    study Design Assessment
    category
    review
    is Randomized Controlled Trial
    false
    peer Reviewed
    true
    basis
    Systematic scoping review/meta-analysis
    masking Roles
    Not applicable or not established from inspected methods; no masking inferred
    sources

    https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

    review Scope
    selected-methods
    paper Trust Assessment
    score
    1
    display Crosses
    1
    scope
    Paper
    status
    assessed
    rating Scale
    library-trust-factor/1-3
    randomized Controlled Trial
    false
    peer Reviewed
    true
    blinding
    not-applicable
    masking Roles
    Not applicable or not established from inspected methods; no masking inferred
    basis
    Systematic scoping review/meta-analysis
    sources

    https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

    assessed At
    2026-11-02
    review Scope
    selected-methods
    human Approval
    false
    review Limit
    AI source-based design assessment; human content sign-off is recorded separately.
    jadad
    status
    not-applicable
    score
    Not recorded
    citation Count
    Not recorded
    citation Snapshot
    count
    Not recorded
    source
    Not recorded
    retrieved At
    Not recorded
    status
    not-assessed
    publication Approval
    status
    approved-for-publication
    approved By
    Ben Korbel
    approved At
    2026-11-02
    assessment
    AI assessed; human approved for publication
    scope
    Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
    source Revision
    r1-9c34edc59e59
    source Content Hash
    9c34edc59e594664e64608aaae23197de4acb75e59222f91f6ba9dad9972be5c
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    level
    selected-methods
    source URLs

    https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

    retrieved At
    2026-11-02
    study Family Id
    publication-34927592
    randomized Study Unit Id
    Not recorded
    institutions
    None recorded
    institution Evidence
    None recorded
    research Topics

    Youth needs / digital / access

    lab Relevance
    relationship
    inspired-by
    implication
    Design responsive, moderated community experiences and measure their quality, including exclusion and negative interactions.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
    publication Status
    pmid
    34927592
    checked At
    2026-11-02T01:32:45.417697+00:00
    pub Types

    Meta-Analysis · Scoping Review · Research Support, Non-U.S. Gov't · review-article · Journal Article

    indexed Notices
    1. source
      MED
      id
      35275072
      reference
      J Med Internet Res. 2022 Mar 11;24(3):e37440. doi: 10.2196/37440
      type
      Comment in
      order In
      1
    2. source
      MED
      id
      35275073
      reference
      J Med Internet Res. 2022 Mar 11;24(3):e36739. doi: 10.2196/36739
      type
      Comment in
      order In
      2
    crossref Updates
    None recorded
    notice Records
    1. pmid
      35275072
      type
      Comment in
      title
      Authors' Reply to: Toward a Better Understanding of Quality Social Connections. Comment on "Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis".
      doi
      10.2196/37440
      pmcid
      PMC8956999
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A35275072+AND+SRC%3AMED&format=json&resultType=core
      sha256
      dc0884d6ad860b0072ba468f1ece85f454115f6f746b55cc91a3f3d4873cb924
      retrieved At
      2026-11-02T01:32:45.417697+00:00
      fulltext URL
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8956999/fullTextXML
      fulltext SHA256
      0e5197c0afb973a1f1a15dd0323714f22d7dc328012f2f7084b565e999c62e11
    2. pmid
      35275073
      type
      Comment in
      title
      Toward a Better Understanding of Quality Social Connections. Comment on "Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis".
      doi
      10.2196/36739
      pmcid
      PMC8957003
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A35275073+AND+SRC%3AMED&format=json&resultType=core
      sha256
      f429df2ff7bc0ee81f526f515ffd4c3f42271e5c2d9b63f0a23114d0c1ea0f1b
      retrieved At
      2026-11-02T01:32:45.417697+00:00
      fulltext URL
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8957003/fullTextXML
      fulltext SHA256
      cff20b09f689caeb884fefe88d057c0938b76227fb9900c02e71f0008b89ef9d
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Published comment questioned duplicate inclusion. Authors replied that the two reports had different designs/outcomes and neither entered the meta-analysis; both sides retained.
    approaches

    Youth needs / digital / access

    record Id
    youth-pmid-34927592
    source Pages
    None recorded
    assessment Record
    id
    youth-pmid-34927592
    title
    Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.
    authors
    Dewa LH, Lawrance E, Roberts L, Brooks-Hall E, Ashrafian H, Fontana G, Aylin P.
    year
    2021
    journal
    Journal of medical Internet research
    doi
    10.2196/26584
    pmid
    34927592
    pmcid
    PMC8726025
    trial Registries
    None recorded
    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    collection
    youth-20261102
    topics

    Youth needs / digital / access

    institutions
    None recorded
    institution Evidence
    None recorded
    publication Type

    Meta-Analysis · Scoping Review · Research Support, Non-U.S. Gov't · review-article · Journal Article

    study Family Id
    publication-34927592
    randomized Study Unit Id
    Not recorded
    existing Repository Matches
    None recorded
    population
    age
    Target 14–24
    age Fit
    mixed-overlap
    sample
    42 studies, 23319 participants; ten pooled
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    intervention
    description And Dose
    Not applicable or not established from inspected sections
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    design
    description
    Systematic scoping review/meta-analysis
    category
    review
    randomization Methods Inspected
    false
    masking
    Not applicable or not established from inspected methods; no masking inferred
    double Blinding Verified
    false
    proposed Crosses
    1
    approved Crosses
    Not recorded
    findings
    Quality connection involved rapport, common identity, being valued and receiving responses; anonymity/privacy could help, while negative interactions or disconnection could hinder.
    limitations
    Mostly uncontrolled/cross-sectional evidence and only 10% double-screening. Pooled symptom changes cannot isolate a causal social-connection effect; percentage-style abstract wording is not an individual clinical improvement rate.
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    lab Relevance
    relationship
    inspired-by
    implication
    Design responsive, moderated community experiences and measure their quality, including exclusion and negative interactions.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    sources
    1. type
      primary bibliographic record
      url
      https://pubmed.ncbi.nlm.nih.gov/34927592/
      retrieved At
      2026-11-02
      sha256
      b06e838155eb81d38ea9f3626c9fbddfb761b370fb4ab0a05b4d717f523f8824
      hash Scope
      normalized Europe PMC core metadata snapshot
    2. type
      publisher DOI
      url
      https://doi.org/10.2196/26584
      retrieved At
      2026-11-02
    3. type
      PMC article
      url
      https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/
      retrieved At
      2026-11-02
      access
      Full text cached
    4. type
      full-text-xml
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML
      retrieved At
      2026-11-02T01:20:57.876815+00:00
      sha256
      763c2751495ed5d2c498a75c1edcde90f9b6c8c068f5576b18bf5840dd0128c6
    5. type
      DOI-metadata
      url
      https://api.crossref.org/works/10.2196%2F26584
      retrieved At
      2026-11-02T01:20:58.889528+00:00
      sha256
      f35df29b3c49cbf22b8b987798af861696c94e68d351f7d1da3ecc7f3fa54eba
    publication Status
    pmid
    34927592
    checked At
    2026-11-02T01:32:45.417697+00:00
    pub Types

    Meta-Analysis · Scoping Review · Research Support, Non-U.S. Gov't · review-article · Journal Article

    indexed Notices
    1. source
      MED
      id
      35275072
      reference
      J Med Internet Res. 2022 Mar 11;24(3):e37440. doi: 10.2196/37440
      type
      Comment in
      order In
      1
    2. source
      MED
      id
      35275073
      reference
      J Med Internet Res. 2022 Mar 11;24(3):e36739. doi: 10.2196/36739
      type
      Comment in
      order In
      2
    crossref Updates
    None recorded
    notice Records
    1. pmid
      35275072
      type
      Comment in
      title
      Authors' Reply to: Toward a Better Understanding of Quality Social Connections. Comment on "Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis".
      doi
      10.2196/37440
      pmcid
      PMC8956999
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A35275072+AND+SRC%3AMED&format=json&resultType=core
      sha256
      dc0884d6ad860b0072ba468f1ece85f454115f6f746b55cc91a3f3d4873cb924
      retrieved At
      2026-11-02T01:32:45.417697+00:00
      fulltext URL
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8956999/fullTextXML
      fulltext SHA256
      0e5197c0afb973a1f1a15dd0323714f22d7dc328012f2f7084b565e999c62e11
    2. pmid
      35275073
      type
      Comment in
      title
      Toward a Better Understanding of Quality Social Connections. Comment on "Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis".
      doi
      10.2196/36739
      pmcid
      PMC8957003
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A35275073+AND+SRC%3AMED&format=json&resultType=core
      sha256
      f429df2ff7bc0ee81f526f515ffd4c3f42271e5c2d9b63f0a23114d0c1ea0f1b
      retrieved At
      2026-11-02T01:32:45.417697+00:00
      fulltext URL
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8957003/fullTextXML
      fulltext SHA256
      cff20b09f689caeb884fefe88d057c0938b76227fb9900c02e71f0008b89ef9d
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Published comment questioned duplicate inclusion. Authors replied that the two reports had different designs/outcomes and neither entered the meta-analysis; both sides retained.
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
    false
    jadad Score
    Not recorded
    review Ready
    true
    hold Reason
    Not recorded
    duplicate Of
    Not recorded
    review
    status
    pending
    reviewer
    Not recorded
    approved At
    Not recorded
    decision Scope
    Ben reviews proposed content and release; full medical-paper reading is not required.
    provenance
    Discovered and appraised by AI; pending human content sign-off
    production Eligible
    false
    approved Retrieval Eligible
    false
    selected Corpus References
    None recorded
    reference Scope
    Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
    content Hash
    9c34edc59e594664e64608aaae23197de4acb75e59222f91f6ba9dad9972be5c
    revision
    r1-9c34edc59e59
    archive Entries
    None recorded
    collection
    language
    chapter Number
    6
    topic Id
    universal-mind-mobile-lab
    topic Title
    Universal Mind Mobile Lab · Direct response and inspired by
    trust Score
    3
  2. id
    language-youth-access-connection-youth-pmid-34927592
    aliases
    None recorded
    title
    Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.
    authors
    Dewa LH, Lawrance E, Roberts L, Brooks-Hall E, Ashrafian H, Fontana G, Aylin P.
    year
    2021
    journal
    Journal of medical Internet research
    doi
    10.2196/26584
    pmid
    34927592
    urls

    https://doi.org/10.2196/26584 · https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

    collections

    language

    categories

    Methods & context

    targets
    None recorded
    neurotransmitters
    None recorded
    conditions

    anxiety · depression

    condition Evidence
    1. id
      anxiety
      evidence
      1. field
        title
        text
        Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.
        matched Text
        Anxiety
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    2. id
      depression
      evidence
      1. field
        title
        text
        Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.
        matched Text
        Depression
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    age Groups

    adolescents · youth · adults

    age Population
    record Id
    youth-pmid-34927592
    collections

    language

    groups

    adolescents · youth · adults

    reported Ages
    Target 14–24
    youth Scope
    included
    youth Source Note
    The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
    age Fit
    mixed-overlap
    source URL
    https://pubmed.ncbi.nlm.nih.gov/34927592/
    basis Type
    selected-methods-ai-editorial-assessment
    classification Note
    Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
    community Matches
    None recorded
    kind
    Review
    design
    Systematic review / meta-analysis
    origin
    approved-youth-20261102
    priority
    1
    quotes
    None recorded
    finding
    Quality connection involved rapport, common identity, being valued and receiving responses; anonymity/privacy could help, while negative interactions or disconnection could hinder.
    summary
    Quality connection involved rapport, common identity, being valued and receiving responses; anonymity/privacy could help, while negative interactions or disconnection could hinder.
    limitation
    Mostly uncontrolled/cross-sectional evidence and only 10% double-screening. Pooled symptom changes cannot isolate a causal social-connection effect; percentage-style abstract wording is not an individual clinical improvement rate.
    evidence
    evidence Type
    Systematic review / meta-analysis
    intervention
    Not applicable or not established from inspected sections
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    sample
    42 studies, 23319 participants; ten pooled
    population
    age
    Target 14–24
    age Fit
    mixed-overlap
    sample
    42 studies, 23319 participants; ten pooled
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    measurement
    Specific outcomes are reported in the finding and retained appraisal.
    trial Id
    publication-34927592
    trial Registries
    None recorded
    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    relationship Note
    Design responsive, moderated community experiences and measure their quality, including exclusion and negative interactions. Component evidence does not establish efficacy of the combined Universal Mind lab model.
    measured Genes
    None recorded
    pathways
    None recorded
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
    false
    jadad Score
    Not recorded
    masking Roles
    Not applicable or not established from inspected methods; no masking inferred
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    level
    selected-methods
    source URLs

    https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

    retrieved At
    2026-11-02
    study Design Assessment
    category
    review
    is Randomized Controlled Trial
    false
    peer Reviewed
    true
    basis
    Systematic scoping review/meta-analysis
    masking Roles
    Not applicable or not established from inspected methods; no masking inferred
    sources

    https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

    review Scope
    selected-methods
    paper Trust Assessment
    score
    1
    display Crosses
    1
    scope
    Paper
    status
    assessed
    rating Scale
    library-trust-factor/1-3
    randomized Controlled Trial
    false
    peer Reviewed
    true
    blinding
    not-applicable
    masking Roles
    Not applicable or not established from inspected methods; no masking inferred
    basis
    Systematic scoping review/meta-analysis
    sources

    https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

    assessed At
    2026-11-02
    review Scope
    selected-methods
    human Approval
    false
    review Limit
    AI source-based design assessment; human content sign-off is recorded separately.
    jadad
    status
    not-applicable
    score
    Not recorded
    citation Count
    Not recorded
    citation Snapshot
    count
    Not recorded
    source
    Not recorded
    retrieved At
    Not recorded
    status
    not-assessed
    publication Approval
    status
    approved-for-publication
    approved By
    Ben Korbel
    approved At
    2026-11-02
    assessment
    AI assessed; human approved for publication
    scope
    Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
    source Revision
    r1-9c34edc59e59
    source Content Hash
    9c34edc59e594664e64608aaae23197de4acb75e59222f91f6ba9dad9972be5c
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    level
    selected-methods
    source URLs

    https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

    retrieved At
    2026-11-02
    study Family Id
    publication-34927592
    randomized Study Unit Id
    Not recorded
    institutions
    None recorded
    institution Evidence
    None recorded
    research Topics

    Youth needs / digital / access

    lab Relevance
    relationship
    inspired-by
    implication
    Design responsive, moderated community experiences and measure their quality, including exclusion and negative interactions.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
    publication Status
    pmid
    34927592
    checked At
    2026-11-02T01:32:45.417697+00:00
    pub Types

    Meta-Analysis · Scoping Review · Research Support, Non-U.S. Gov't · review-article · Journal Article

    indexed Notices
    1. source
      MED
      id
      35275072
      reference
      J Med Internet Res. 2022 Mar 11;24(3):e37440. doi: 10.2196/37440
      type
      Comment in
      order In
      1
    2. source
      MED
      id
      35275073
      reference
      J Med Internet Res. 2022 Mar 11;24(3):e36739. doi: 10.2196/36739
      type
      Comment in
      order In
      2
    crossref Updates
    None recorded
    notice Records
    1. pmid
      35275072
      type
      Comment in
      title
      Authors' Reply to: Toward a Better Understanding of Quality Social Connections. Comment on "Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis".
      doi
      10.2196/37440
      pmcid
      PMC8956999
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A35275072+AND+SRC%3AMED&format=json&resultType=core
      sha256
      dc0884d6ad860b0072ba468f1ece85f454115f6f746b55cc91a3f3d4873cb924
      retrieved At
      2026-11-02T01:32:45.417697+00:00
      fulltext URL
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8956999/fullTextXML
      fulltext SHA256
      0e5197c0afb973a1f1a15dd0323714f22d7dc328012f2f7084b565e999c62e11
    2. pmid
      35275073
      type
      Comment in
      title
      Toward a Better Understanding of Quality Social Connections. Comment on "Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis".
      doi
      10.2196/36739
      pmcid
      PMC8957003
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A35275073+AND+SRC%3AMED&format=json&resultType=core
      sha256
      f429df2ff7bc0ee81f526f515ffd4c3f42271e5c2d9b63f0a23114d0c1ea0f1b
      retrieved At
      2026-11-02T01:32:45.417697+00:00
      fulltext URL
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8957003/fullTextXML
      fulltext SHA256
      cff20b09f689caeb884fefe88d057c0938b76227fb9900c02e71f0008b89ef9d
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Published comment questioned duplicate inclusion. Authors replied that the two reports had different designs/outcomes and neither entered the meta-analysis; both sides retained.
    approaches

    Youth needs / digital / access

    record Id
    youth-pmid-34927592
    source Pages
    None recorded
    assessment Record
    id
    youth-pmid-34927592
    title
    Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.
    authors
    Dewa LH, Lawrance E, Roberts L, Brooks-Hall E, Ashrafian H, Fontana G, Aylin P.
    year
    2021
    journal
    Journal of medical Internet research
    doi
    10.2196/26584
    pmid
    34927592
    pmcid
    PMC8726025
    trial Registries
    None recorded
    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    collection
    youth-20261102
    topics

    Youth needs / digital / access

    institutions
    None recorded
    institution Evidence
    None recorded
    publication Type

    Meta-Analysis · Scoping Review · Research Support, Non-U.S. Gov't · review-article · Journal Article

    study Family Id
    publication-34927592
    randomized Study Unit Id
    Not recorded
    existing Repository Matches
    None recorded
    population
    age
    Target 14–24
    age Fit
    mixed-overlap
    sample
    42 studies, 23319 participants; ten pooled
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    intervention
    description And Dose
    Not applicable or not established from inspected sections
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    design
    description
    Systematic scoping review/meta-analysis
    category
    review
    randomization Methods Inspected
    false
    masking
    Not applicable or not established from inspected methods; no masking inferred
    double Blinding Verified
    false
    proposed Crosses
    1
    approved Crosses
    Not recorded
    findings
    Quality connection involved rapport, common identity, being valued and receiving responses; anonymity/privacy could help, while negative interactions or disconnection could hinder.
    limitations
    Mostly uncontrolled/cross-sectional evidence and only 10% double-screening. Pooled symptom changes cannot isolate a causal social-connection effect; percentage-style abstract wording is not an individual clinical improvement rate.
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    lab Relevance
    relationship
    inspired-by
    implication
    Design responsive, moderated community experiences and measure their quality, including exclusion and negative interactions.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    sources
    1. type
      primary bibliographic record
      url
      https://pubmed.ncbi.nlm.nih.gov/34927592/
      retrieved At
      2026-11-02
      sha256
      b06e838155eb81d38ea9f3626c9fbddfb761b370fb4ab0a05b4d717f523f8824
      hash Scope
      normalized Europe PMC core metadata snapshot
    2. type
      publisher DOI
      url
      https://doi.org/10.2196/26584
      retrieved At
      2026-11-02
    3. type
      PMC article
      url
      https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/
      retrieved At
      2026-11-02
      access
      Full text cached
    4. type
      full-text-xml
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML
      retrieved At
      2026-11-02T01:20:57.876815+00:00
      sha256
      763c2751495ed5d2c498a75c1edcde90f9b6c8c068f5576b18bf5840dd0128c6
    5. type
      DOI-metadata
      url
      https://api.crossref.org/works/10.2196%2F26584
      retrieved At
      2026-11-02T01:20:58.889528+00:00
      sha256
      f35df29b3c49cbf22b8b987798af861696c94e68d351f7d1da3ecc7f3fa54eba
    publication Status
    pmid
    34927592
    checked At
    2026-11-02T01:32:45.417697+00:00
    pub Types

    Meta-Analysis · Scoping Review · Research Support, Non-U.S. Gov't · review-article · Journal Article

    indexed Notices
    1. source
      MED
      id
      35275072
      reference
      J Med Internet Res. 2022 Mar 11;24(3):e37440. doi: 10.2196/37440
      type
      Comment in
      order In
      1
    2. source
      MED
      id
      35275073
      reference
      J Med Internet Res. 2022 Mar 11;24(3):e36739. doi: 10.2196/36739
      type
      Comment in
      order In
      2
    crossref Updates
    None recorded
    notice Records
    1. pmid
      35275072
      type
      Comment in
      title
      Authors' Reply to: Toward a Better Understanding of Quality Social Connections. Comment on "Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis".
      doi
      10.2196/37440
      pmcid
      PMC8956999
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A35275072+AND+SRC%3AMED&format=json&resultType=core
      sha256
      dc0884d6ad860b0072ba468f1ece85f454115f6f746b55cc91a3f3d4873cb924
      retrieved At
      2026-11-02T01:32:45.417697+00:00
      fulltext URL
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8956999/fullTextXML
      fulltext SHA256
      0e5197c0afb973a1f1a15dd0323714f22d7dc328012f2f7084b565e999c62e11
    2. pmid
      35275073
      type
      Comment in
      title
      Toward a Better Understanding of Quality Social Connections. Comment on "Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis".
      doi
      10.2196/36739
      pmcid
      PMC8957003
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A35275073+AND+SRC%3AMED&format=json&resultType=core
      sha256
      f429df2ff7bc0ee81f526f515ffd4c3f42271e5c2d9b63f0a23114d0c1ea0f1b
      retrieved At
      2026-11-02T01:32:45.417697+00:00
      fulltext URL
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8957003/fullTextXML
      fulltext SHA256
      cff20b09f689caeb884fefe88d057c0938b76227fb9900c02e71f0008b89ef9d
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Published comment questioned duplicate inclusion. Authors replied that the two reports had different designs/outcomes and neither entered the meta-analysis; both sides retained.
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
    false
    jadad Score
    Not recorded
    review Ready
    true
    hold Reason
    Not recorded
    duplicate Of
    Not recorded
    review
    status
    pending
    reviewer
    Not recorded
    approved At
    Not recorded
    decision Scope
    Ben reviews proposed content and release; full medical-paper reading is not required.
    provenance
    Discovered and appraised by AI; pending human content sign-off
    production Eligible
    false
    approved Retrieval Eligible
    false
    selected Corpus References
    None recorded
    reference Scope
    Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
    content Hash
    9c34edc59e594664e64608aaae23197de4acb75e59222f91f6ba9dad9972be5c
    revision
    r1-9c34edc59e59
    archive Entries
    None recorded
    collection
    language
    chapter Number
    6
    topic Id
    youth-access-connection
    topic Title
    Youth access, digital support and connection
    trust Score
    3
evidence
evidence Type
Systematic review / meta-analysis
intervention
Not applicable or not established from inspected sections
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
42 studies, 23319 participants; ten pooled
population
age
Target 14–24
age Fit
mixed-overlap
sample
42 studies, 23319 participants; ten pooled
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
publication-34927592
trial Registries
None recorded
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Design responsive, moderated community experiences and measure their quality, including exclusion and negative interactions. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
qualified
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Not applicable or not established from inspected methods; no masking inferred
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs

https://pubmed.ncbi.nlm.nih.gov/34927592/ · https://doi.org/10.2196/26584 · https://pmc.ncbi.nlm.nih.gov/articles/PMC8726025/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8726025/fullTextXML · https://api.crossref.org/works/10.2196%2F26584

retrieved At
2026-11-02
jadad
status
not-applicable
score
Not recorded
condition Evidence
  1. id
    anxiety
    evidence
    1. field
      title
      text
      Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.
      matched Text
      Anxiety
    scope
    Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
  2. id
    depression
    evidence
    1. field
      title
      text
      Quality Social Connection as an Active Ingredient in Digital Interventions for Young People With Depression and Anxiety: Systematic Scoping Review and Meta-analysis.
      matched Text
      Depression
    scope
    Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
conditions

anxiety · depression

topic Trust Scores

3

full Text
status
not-indexed
retrieval Available
false

Open this publication in the interactive library