The effect of psychological treatment on repetitive negative thinking in youth depression and anxiety: a meta-analysis and meta-regression.
Bell IH, Marx W, Nguyen K, Grace S, Gleeson J, Alvarez-Jimenez M. · Psychological medicine · 2023 · Systematic review / meta-analysis
Original publication · Original publication · Original publication · Original publication · Original publication
Recorded summary
Small-to-moderate reductions in repetitive negative thinking, depression and anxiety; process-focused approaches appeared stronger for RNT, but RNT-specific approaches were not consistently superior overall.
Recorded limitations
Heterogeneous approaches and aggregate meta-regression cannot prove that RNT change causes symptom improvement.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Systematic review / meta-analysis
- assessment
- category
- review
- is Randomized Controlled Trial
- false
- peer Reviewed
- true
- basis
- Meta-analysis/meta-regression of RCTs
- masking Roles
- Not applicable or not established from inspected methods; no masking inferred
- sources
https://pubmed.ncbi.nlm.nih.gov/36373473/ · https://doi.org/10.1017/s0033291722003373 · https://pmc.ncbi.nlm.nih.gov/articles/PMC9875014/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9875014/fullTextXML · https://api.crossref.org/works/10.1017%2Fs0033291722003373
- review Scope
- selected-methods
- trust Factor
- score
- 1
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- 1
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- Paper
- status
- assessed
- rating Scale
- library-trust-factor/1-3
- randomized Controlled Trial
- false
- peer Reviewed
- true
- blinding
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- masking Roles
- Not applicable or not established from inspected methods; no masking inferred
- basis
- Meta-analysis/meta-regression of RCTs
- sources
https://pubmed.ncbi.nlm.nih.gov/36373473/ · https://doi.org/10.1017/s0033291722003373 · https://pmc.ncbi.nlm.nih.gov/articles/PMC9875014/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9875014/fullTextXML · https://api.crossref.org/works/10.1017%2Fs0033291722003373
- assessed At
- 2026-11-02
- review Scope
- selected-methods
- human Approval
- false
- review Limit
- AI source-based design assessment; human content sign-off is recorded separately.
- jadad
- status
- not-applicable
- score
- Not recorded
- evidence
- evidence Type
- Systematic review / meta-analysis
- intervention
- Not applicable or not established from inspected sections
- provider
- Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
- comparator
- See design/intervention description; otherwise unknown
- sample
- 28 RCTs, 17 psychological approaches
- population
- age
- Eligible sample means 14–24
- age Fit
- mixed-overlap
- sample
- 28 RCTs, 17 psychological approaches
- setting
- Not separately established; see population/intervention description
- community
- Not assigned
- measurement
- Specific outcomes are reported in the finding and retained appraisal.
- trial Id
- publication-36373473
- trial Registries
- None recorded
- registry Scope
- Identifiers explicitly reported in article abstract; other registrations remain unverified
- relationship Note
- Mindfulness/acceptance skills may be candidate mechanisms to measure, alongside clinical pathways. Component evidence does not establish efficacy of the combined Universal Mind lab model.
- measured Genes
- None recorded
- pathways
- None recorded
- quality
- tier
- qualified
- qualification
- Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
- formal Risk Of Bias Tool Applied
- false
- jadad Score
- Not recorded
- masking Roles
- Not applicable or not established from inspected methods; no masking inferred
- harms And Attrition
- Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
- source Access
- scope
- selected-methods
- full Text Cached
- true
- methods Inspected
- true
- full Text Appraisal Claim
- false
- level
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https://pubmed.ncbi.nlm.nih.gov/36373473/ · https://doi.org/10.1017/s0033291722003373 · https://pmc.ncbi.nlm.nih.gov/articles/PMC9875014/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9875014/fullTextXML · https://api.crossref.org/works/10.1017%2Fs0033291722003373
- retrieved At
- 2026-11-02
Topics and recorded topic scores
- key
- language:orygen-youth
- title
- Orygen · Youth research
- collection
- language
- trust Score
- 2
- key
- language:universal-mind-mobile-lab
- title
- Universal Mind Mobile Lab · Direct response and inspired by
- collection
- language
- trust Score
- 3
- key
- language:youth-access-connection
- title
- Youth access, digital support and connection
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- trust Score
- 3
Citation snapshot and identifiers
- id
- youth-pmid-36373473
- doi
- 10.1017/s0033291722003373
- pmid
- 36373473
- citation Snapshot
- count
- Not recorded
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- Not recorded
- retrieved At
- Not recorded
- status
- not-assessed
- citations By Collection
- language
- Not recorded
Complete approved library record
- lab Relevance
- relationship
- inspired-by
- implication
- Mindfulness/acceptance skills may be candidate mechanisms to measure, alongside clinical pathways.
- transfer Limit
- Component evidence does not establish efficacy of the combined Universal Mind lab model.
- institutions
Orygen
- institution Evidence
- institution
- Orygen
- basis
- Author affiliation in primary indexed metadata or publisher full text
- evidence
- Orygen, Melbourne, Australia.
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Youth needs / digital / access
- publication Status
- pmid
- 36373473
- checked At
- 2026-11-02T01:32:46.750619+00:00
- pub Types
Meta-Analysis · Research Support, Non-U.S. Gov't · review-article · Review · Journal Article
- indexed Notices
- None recorded
- crossref Updates
- None recorded
- notice Records
- None recorded
- scope
- Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
- notice Summary
- Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
- randomized Study Unit Id
- Not recorded
- publication Approval
- status
- approved-for-publication
- approved By
- Ben Korbel
- approved At
- 2026-11-02
- assessment
- AI assessed; human approved for publication
- scope
- Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
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- study Family Id
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Youth needs / digital / access
- id
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- aliases
- None recorded
- title
- The effect of psychological treatment on repetitive negative thinking in youth depression and anxiety: a meta-analysis and meta-regression.
- journal
- Psychological medicine
- neurotransmitters
- None recorded
- year
- 2023
- authors
- Bell IH, Marx W, Nguyen K, Grace S, Gleeson J, Alvarez-Jimenez M.
- design
- Systematic review / meta-analysis
- kind
- Review
- identity Conflict
- Not recorded
- doi
- 10.1017/s0033291722003373
- pmid
- 36373473
- urls
https://doi.org/10.1017/s0033291722003373 · https://pubmed.ncbi.nlm.nih.gov/36373473/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC9875014/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9875014/fullTextXML · https://api.crossref.org/works/10.1017%2Fs0033291722003373
- collections
language
- categories
Methods & context
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- Small-to-moderate reductions in repetitive negative thinking, depression and anxiety; process-focused approaches appeared stronger for RNT, but RNT-specific approaches were not consistently superior overall.
- limitation
- Heterogeneous approaches and aggregate meta-regression cannot prove that RNT change causes symptom improvement.
- citation Count
- Not recorded
- citation Snapshot
- count
- Not recorded
- source
- Not recorded
- retrieved At
- Not recorded
- status
- not-assessed
- study Design Assessment
- category
- review
- is Randomized Controlled Trial
- false
- peer Reviewed
- true
- basis
- Meta-analysis/meta-regression of RCTs
- masking Roles
- Not applicable or not established from inspected methods; no masking inferred
- sources
https://pubmed.ncbi.nlm.nih.gov/36373473/ · https://doi.org/10.1017/s0033291722003373 · https://pmc.ncbi.nlm.nih.gov/articles/PMC9875014/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9875014/fullTextXML · https://api.crossref.org/works/10.1017%2Fs0033291722003373
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https://pubmed.ncbi.nlm.nih.gov/36373473/ · https://doi.org/10.1017/s0033291722003373 · https://pmc.ncbi.nlm.nih.gov/articles/PMC9875014/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9875014/fullTextXML · https://api.crossref.org/works/10.1017%2Fs0033291722003373
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- title
- The effect of psychological treatment on repetitive negative thinking in youth depression and anxiety: a meta-analysis and meta-regression.
- authors
- Bell IH, Marx W, Nguyen K, Grace S, Gleeson J, Alvarez-Jimenez M.
- year
- 2023
- journal
- Psychological medicine
- doi
- 10.1017/s0033291722003373
- pmid
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Methods & context
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- None recorded
- neurotransmitters
- None recorded
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anxiety · depression
- condition Evidence
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- The effect of psychological treatment on repetitive negative thinking in youth depression and anxiety: a meta-analysis and meta-regression.
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- text
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- matched Text
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adolescents · youth · adults
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- https://pubmed.ncbi.nlm.nih.gov/36373473/
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- finding
- Small-to-moderate reductions in repetitive negative thinking, depression and anxiety; process-focused approaches appeared stronger for RNT, but RNT-specific approaches were not consistently superior overall.
- summary
- Small-to-moderate reductions in repetitive negative thinking, depression and anxiety; process-focused approaches appeared stronger for RNT, but RNT-specific approaches were not consistently superior overall.
- limitation
- Heterogeneous approaches and aggregate meta-regression cannot prove that RNT change causes symptom improvement.
- evidence
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- Systematic review / meta-analysis
- intervention
- Not applicable or not established from inspected sections
- provider
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- relationship Note
- Mindfulness/acceptance skills may be candidate mechanisms to measure, alongside clinical pathways. Component evidence does not establish efficacy of the combined Universal Mind lab model.
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https://pubmed.ncbi.nlm.nih.gov/36373473/ · https://doi.org/10.1017/s0033291722003373 · https://pmc.ncbi.nlm.nih.gov/articles/PMC9875014/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9875014/fullTextXML · https://api.crossref.org/works/10.1017%2Fs0033291722003373
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- evidence
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Youth needs / digital / access
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- inspired-by
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- Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
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- Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
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Youth needs / digital / access
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- The effect of psychological treatment on repetitive negative thinking in youth depression and anxiety: a meta-analysis and meta-regression.
- authors
- Bell IH, Marx W, Nguyen K, Grace S, Gleeson J, Alvarez-Jimenez M.
- year
- 2023
- journal
- Psychological medicine
- doi
- 10.1017/s0033291722003373
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Youth needs / digital / access
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Orygen
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- Eligible sample means 14–24
- age Fit
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- 28 RCTs, 17 psychological approaches
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- limitations
- Heterogeneous approaches and aggregate meta-regression cannot prove that RNT change causes symptom improvement.
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- lab Relevance
- relationship
- inspired-by
- implication
- Mindfulness/acceptance skills may be candidate mechanisms to measure, alongside clinical pathways.
- transfer Limit
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- Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
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- Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
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Meta-Analysis · Research Support, Non-U.S. Gov't · review-article · Review · Journal Article
- indexed Notices
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- crossref Updates
- None recorded
- notice Records
- None recorded
- scope
- Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
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- Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
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- Ben reviews proposed content and release; full medical-paper reading is not required.
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- None recorded
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- Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
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- Specific outcomes are reported in the finding and retained appraisal.
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- publication-36373473
- trial Registries
- None recorded
- registry Scope
- Identifiers explicitly reported in article abstract; other registrations remain unverified
- relationship Note
- Mindfulness/acceptance skills may be candidate mechanisms to measure, alongside clinical pathways. Component evidence does not establish efficacy of the combined Universal Mind lab model.
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https://pubmed.ncbi.nlm.nih.gov/36373473/ · https://doi.org/10.1017/s0033291722003373 · https://pmc.ncbi.nlm.nih.gov/articles/PMC9875014/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9875014/fullTextXML · https://api.crossref.org/works/10.1017%2Fs0033291722003373
- retrieved At
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- The effect of psychological treatment on repetitive negative thinking in youth depression and anxiety: a meta-analysis and meta-regression.
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- matched Text
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anxiety · depression
- topic Trust Scores
2 · 3
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