A Personalized, Transdiagnostic Smartphone Intervention (Mello) Targeting Repetitive Negative Thinking in Young People With Depression and Anxiety: Pilot Randomized Controlled Trial.
Bell I, Arnold C, Gilbertson T, D'Alfonso S, Castagnini E, Chen N, Nicholas J, O'Sullivan S, Valentine L, Alvarez-Jimenez M. · Journal of medical Internet research · 2023 · Randomized controlled trial report · double blinding not verified
Original publication · Original publication · Original publication · Original publication · Original publication
Recorded summary
Promising preliminary depression, anxiety and repetitive-thinking effects; app use fell from 90% at week three to 59% at week six.
Recorded limitations
Small pilot, inactive comparator and extra contact. Mediation is exploratory and does not prove mechanism.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial report · double blinding not verified
- assessment
- category
- rct-masking-unclear
- is Randomized Controlled Trial
- true
- peer Reviewed
- true
- basis
- Pilot RCT
- masking Roles
- Allocation concealed in REDCap; participants and researchers explicitly unblinded.
- sources
https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://doi.org/10.2196/47860 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
- review Scope
- selected-methods
- trust Factor
- score
- 2
- display Crosses
- 2
- scope
- Paper
- status
- assessed
- rating Scale
- library-trust-factor/1-3
- randomized Controlled Trial
- true
- peer Reviewed
- true
- blinding
- not-confirmed
- masking Roles
- Allocation concealed in REDCap; participants and researchers explicitly unblinded.
- basis
- Pilot RCT
- sources
https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://doi.org/10.2196/47860 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
- assessed At
- 2026-11-02
- review Scope
- selected-methods
- human Approval
- false
- review Limit
- AI source-based design assessment; human content sign-off is recorded separately.
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Randomized controlled trial report · double blinding not verified
- intervention
- Mello adaptive app for six weeks plus brief weekly encouragement calls versus inactive control
- provider
- Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
- comparator
- See design/intervention description; otherwise unknown
- sample
- 55 randomized; 52 retained at six weeks
- population
- age
- 16–25
- age Fit
- mixed-overlap
- sample
- 55 randomized; 52 retained at six weeks
- setting
- Not separately established; see population/intervention description
- community
- Not assigned
- measurement
- Specific outcomes are reported in the finding and retained appraisal.
- trial Id
- publication-38090786
- trial Registries
ACTRN12621001701819
- registry Scope
- Identifiers explicitly reported in article abstract; other registrations remain unverified
- relationship Note
- Test personalised digital support with engagement and clinical monitoring; do not extrapolate pilot efficacy to an academy. Component evidence does not establish efficacy of the combined Universal Mind lab model.
- measured Genes
- None recorded
- pathways
- None recorded
- quality
- tier
- qualified
- qualification
- Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
- formal Risk Of Bias Tool Applied
- false
- jadad Score
- Not recorded
- masking Roles
- Allocation concealed in REDCap; participants and researchers explicitly unblinded.
- harms And Attrition
- Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
- source Access
- scope
- selected-methods
- full Text Cached
- true
- methods Inspected
- true
- full Text Appraisal Claim
- false
- level
- selected-methods
- source URLs
https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://doi.org/10.2196/47860 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
- retrieved At
- 2026-11-02
Topics and recorded topic scores
- key
- language:orygen-youth
- title
- Orygen · Youth research
- collection
- language
- trust Score
- 2
- key
- language:universal-mind-mobile-lab
- title
- Universal Mind Mobile Lab · Direct response and inspired by
- collection
- language
- trust Score
- 3
- key
- language:youth-access-connection
- title
- Youth access, digital support and connection
- collection
- language
- trust Score
- 3
Citation snapshot and identifiers
- id
- youth-pmid-38090786
- doi
- 10.2196/47860
- pmid
- 38090786
- citation Snapshot
- count
- Not recorded
- source
- Not recorded
- retrieved At
- Not recorded
- status
- not-assessed
- citations By Collection
- language
- Not recorded
Complete approved library record
- lab Relevance
- relationship
- inspired-by
- implication
- Test personalised digital support with engagement and clinical monitoring; do not extrapolate pilot efficacy to an academy.
- transfer Limit
- Component evidence does not establish efficacy of the combined Universal Mind lab model.
- institutions
Orygen
- institution Evidence
- institution
- Orygen
- basis
- Author affiliation in primary indexed metadata or publisher full text
- evidence
- Orygen, Melbourne, Australia.
- research Topics
Youth needs / digital / access
- publication Status
- pmid
- 38090786
- checked At
- 2026-11-02T01:32:46.760800+00:00
- pub Types
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
- indexed Notices
- None recorded
- crossref Updates
- None recorded
- notice Records
- None recorded
- scope
- Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
- notice Summary
- Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
- randomized Study Unit Id
- publication-38090786
- publication Approval
- status
- approved-for-publication
- approved By
- Ben Korbel
- approved At
- 2026-11-02
- assessment
- AI assessed; human approved for publication
- scope
- Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
- source Revision
- r1-0c1759be048f
- source Content Hash
- 0c1759be048f920d76efbe4df7a18ee60bec40e47b77115c95a6f9afbd743cad
- source Access
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- full Text Cached
- true
- methods Inspected
- true
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- false
- level
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- source URLs
https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://doi.org/10.2196/47860 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
- retrieved At
- 2026-11-02
- study Family Id
- publication-38090786
- approaches
Youth needs / digital / access
- id
- youth-pmid-38090786
- aliases
- None recorded
- title
- A Personalized, Transdiagnostic Smartphone Intervention (Mello) Targeting Repetitive Negative Thinking in Young People With Depression and Anxiety: Pilot Randomized Controlled Trial.
- journal
- Journal of medical Internet research
- neurotransmitters
- None recorded
- year
- 2023
- authors
- Bell I, Arnold C, Gilbertson T, D'Alfonso S, Castagnini E, Chen N, Nicholas J, O'Sullivan S, Valentine L, Alvarez-Jimenez M.
- design
- Randomized controlled trial report · double blinding not verified
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.2196/47860
- pmid
- 38090786
- urls
https://doi.org/10.2196/47860 · https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
- collections
language
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- Promising preliminary depression, anxiety and repetitive-thinking effects; app use fell from 90% at week three to 59% at week six.
- limitation
- Small pilot, inactive comparator and extra contact. Mediation is exploratory and does not prove mechanism.
- citation Count
- Not recorded
- citation Snapshot
- count
- Not recorded
- source
- Not recorded
- retrieved At
- Not recorded
- status
- not-assessed
- study Design Assessment
- category
- rct-masking-unclear
- is Randomized Controlled Trial
- true
- peer Reviewed
- true
- basis
- Pilot RCT
- masking Roles
- Allocation concealed in REDCap; participants and researchers explicitly unblinded.
- sources
https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://doi.org/10.2196/47860 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
- review Scope
- selected-methods
- paper Trust Assessment
- score
- 2
- display Crosses
- 2
- scope
- Paper
- status
- assessed
- rating Scale
- library-trust-factor/1-3
- randomized Controlled Trial
- true
- peer Reviewed
- true
- blinding
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- masking Roles
- Allocation concealed in REDCap; participants and researchers explicitly unblinded.
- basis
- Pilot RCT
- sources
https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://doi.org/10.2196/47860 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
- assessed At
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- language:orygen-youth
- title
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- language:universal-mind-mobile-lab
- title
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- title
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- chapter Entries
- id
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- aliases
- None recorded
- title
- A Personalized, Transdiagnostic Smartphone Intervention (Mello) Targeting Repetitive Negative Thinking in Young People With Depression and Anxiety: Pilot Randomized Controlled Trial.
- authors
- Bell I, Arnold C, Gilbertson T, D'Alfonso S, Castagnini E, Chen N, Nicholas J, O'Sullivan S, Valentine L, Alvarez-Jimenez M.
- year
- 2023
- journal
- Journal of medical Internet research
- doi
- 10.2196/47860
- pmid
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https://doi.org/10.2196/47860 · https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
- collections
language
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Clinical & self-report
- targets
- None recorded
- neurotransmitters
- None recorded
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anxiety · depression
- condition Evidence
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- title
- text
- A Personalized, Transdiagnostic Smartphone Intervention (Mello) Targeting Repetitive Negative Thinking in Young People With Depression and Anxiety: Pilot Randomized Controlled Trial.
- matched Text
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- text
- Promising preliminary depression, anxiety and repetitive-thinking effects; app use fell from 90% at week three to 59% at week six.
- matched Text
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- Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
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- A Personalized, Transdiagnostic Smartphone Intervention (Mello) Targeting Repetitive Negative Thinking in Young People With Depression and Anxiety: Pilot Randomized Controlled Trial.
- matched Text
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- findings
- text
- Promising preliminary depression, anxiety and repetitive-thinking effects; app use fell from 90% at week three to 59% at week six.
- matched Text
- depression
- scope
- Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
- age Groups
adolescents · youth · adults
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language
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adolescents · youth · adults
- reported Ages
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- The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
- age Fit
- mixed-overlap
- source URL
- https://pubmed.ncbi.nlm.nih.gov/38090786/
- basis Type
- selected-methods-ai-editorial-assessment
- classification Note
- Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
- community Matches
- None recorded
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- design
- Randomized controlled trial report · double blinding not verified
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- priority
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- finding
- Promising preliminary depression, anxiety and repetitive-thinking effects; app use fell from 90% at week three to 59% at week six.
- summary
- Promising preliminary depression, anxiety and repetitive-thinking effects; app use fell from 90% at week three to 59% at week six.
- limitation
- Small pilot, inactive comparator and extra contact. Mediation is exploratory and does not prove mechanism.
- evidence
- evidence Type
- Randomized controlled trial report · double blinding not verified
- intervention
- Mello adaptive app for six weeks plus brief weekly encouragement calls versus inactive control
- provider
- Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
- comparator
- See design/intervention description; otherwise unknown
- sample
- 55 randomized; 52 retained at six weeks
- population
- age
- 16–25
- age Fit
- mixed-overlap
- sample
- 55 randomized; 52 retained at six weeks
- setting
- Not separately established; see population/intervention description
- community
- Not assigned
- measurement
- Specific outcomes are reported in the finding and retained appraisal.
- trial Id
- publication-38090786
- trial Registries
ACTRN12621001701819
- registry Scope
- Identifiers explicitly reported in article abstract; other registrations remain unverified
- relationship Note
- Test personalised digital support with engagement and clinical monitoring; do not extrapolate pilot efficacy to an academy. Component evidence does not establish efficacy of the combined Universal Mind lab model.
- measured Genes
- None recorded
- pathways
- None recorded
- quality
- tier
- qualified
- qualification
- Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
- formal Risk Of Bias Tool Applied
- false
- jadad Score
- Not recorded
- masking Roles
- Allocation concealed in REDCap; participants and researchers explicitly unblinded.
- harms And Attrition
- Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
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https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://doi.org/10.2196/47860 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
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- basis
- Pilot RCT
- masking Roles
- Allocation concealed in REDCap; participants and researchers explicitly unblinded.
- sources
https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://doi.org/10.2196/47860 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
- review Scope
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- 2
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- 2
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- library-trust-factor/1-3
- randomized Controlled Trial
- true
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- blinding
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- masking Roles
- Allocation concealed in REDCap; participants and researchers explicitly unblinded.
- basis
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- sources
https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://doi.org/10.2196/47860 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
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- status
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- approved At
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- relationship
- inspired-by
- implication
- Test personalised digital support with engagement and clinical monitoring; do not extrapolate pilot efficacy to an academy.
- transfer Limit
- Component evidence does not establish efficacy of the combined Universal Mind lab model.
- publication Status
- pmid
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- pub Types
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
- indexed Notices
- None recorded
- crossref Updates
- None recorded
- notice Records
- None recorded
- scope
- Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
- notice Summary
- Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
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- title
- A Personalized, Transdiagnostic Smartphone Intervention (Mello) Targeting Repetitive Negative Thinking in Young People With Depression and Anxiety: Pilot Randomized Controlled Trial.
- authors
- Bell I, Arnold C, Gilbertson T, D'Alfonso S, Castagnini E, Chen N, Nicholas J, O'Sullivan S, Valentine L, Alvarez-Jimenez M.
- year
- 2023
- journal
- Journal of medical Internet research
- doi
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Youth needs / digital / access
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- age Fit
- mixed-overlap
- sample
- 55 randomized; 52 retained at six weeks
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- community
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- intervention
- description And Dose
- Mello adaptive app for six weeks plus brief weekly encouragement calls versus inactive control
- provider
- Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
- comparator
- See design/intervention description; otherwise unknown
- design
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- Pilot RCT
- category
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- Promising preliminary depression, anxiety and repetitive-thinking effects; app use fell from 90% at week three to 59% at week six.
- limitations
- Small pilot, inactive comparator and extra contact. Mediation is exploratory and does not prove mechanism.
- harms And Attrition
- Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
- lab Relevance
- relationship
- inspired-by
- implication
- Test personalised digital support with engagement and clinical monitoring; do not extrapolate pilot efficacy to an academy.
- transfer Limit
- Component evidence does not establish efficacy of the combined Universal Mind lab model.
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- indexed Notices
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- crossref Updates
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- scope
- Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
- notice Summary
- Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
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- A Personalized, Transdiagnostic Smartphone Intervention (Mello) Targeting Repetitive Negative Thinking in Young People With Depression and Anxiety: Pilot Randomized Controlled Trial.
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- Bell I, Arnold C, Gilbertson T, D'Alfonso S, Castagnini E, Chen N, Nicholas J, O'Sullivan S, Valentine L, Alvarez-Jimenez M.
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- A Personalized, Transdiagnostic Smartphone Intervention (Mello) Targeting Repetitive Negative Thinking in Young People With Depression and Anxiety: Pilot Randomized Controlled Trial.
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Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
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- crossref Updates
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- notice Records
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- None recorded
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ACTRN12621001701819
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- relationship Note
- Test personalised digital support with engagement and clinical monitoring; do not extrapolate pilot efficacy to an academy. Component evidence does not establish efficacy of the combined Universal Mind lab model.
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https://pubmed.ncbi.nlm.nih.gov/38090786/ · https://doi.org/10.2196/47860 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10753417/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10753417/fullTextXML · https://api.crossref.org/works/10.2196%2F47860
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- A Personalized, Transdiagnostic Smartphone Intervention (Mello) Targeting Repetitive Negative Thinking in Young People With Depression and Anxiety: Pilot Randomized Controlled Trial.
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