Universal Informatics · Research reading room

A systematic review of longitudinal risk and protective factors for loneliness in youth.

Buecker S, Petersen K, Neuber A, Zheng Y, Hayes D, Qualter P. · Annals of the New York Academy of Sciences · 2024 · Review / synthesis

Original publication · Original publication · Original publication · Original publication · Original publication

Recorded summary

Peer rejection/victimisation and several mental-health difficulties consistently preceded later loneliness; many proposed factors lacked replicated evidence.

Recorded limitations

Prospective association is not causal proof; measures, follow-up intervals and baseline adjustment vary.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Review / synthesis
assessment
category
review
is Randomized Controlled Trial
false
peer Reviewed
true
basis
Systematic review of longitudinal observational studies
masking Roles
Not applicable or not established from inspected methods; no masking inferred
sources

https://pubmed.ncbi.nlm.nih.gov/39666705/ · https://doi.org/10.1111/nyas.15266 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11668506/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11668506/fullTextXML · https://api.crossref.org/works/10.1111%2Fnyas.15266

review Scope
selected-methods
trust Factor
score
1
display Crosses
1
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
false
peer Reviewed
true
blinding
not-applicable
masking Roles
Not applicable or not established from inspected methods; no masking inferred
basis
Systematic review of longitudinal observational studies
sources

https://pubmed.ncbi.nlm.nih.gov/39666705/ · https://doi.org/10.1111/nyas.15266 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11668506/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11668506/fullTextXML · https://api.crossref.org/works/10.1111%2Fnyas.15266

assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
not-applicable
score
Not recorded
evidence
evidence Type
Review / synthesis
intervention
Not applicable or not established from inspected sections
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
105 articles
population
age
Below 25, including children
age Fit
mixed-overlap
sample
105 articles
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
publication-39666705
trial Registries
None recorded
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Create inclusive, anti-bullying participation and monitor belonging; evaluate rather than assume a preventive effect. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
qualified
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Not applicable or not established from inspected methods; no masking inferred
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs

https://pubmed.ncbi.nlm.nih.gov/39666705/ · https://doi.org/10.1111/nyas.15266 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11668506/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11668506/fullTextXML · https://api.crossref.org/works/10.1111%2Fnyas.15266

retrieved At
2026-11-02
Topics and recorded topic scores
  1. key
    language:universal-mind-mobile-lab
    title
    Universal Mind Mobile Lab · Direct response and inspired by
    collection
    language
    trust Score
    3
  2. key
    language:youth-access-connection
    title
    Youth access, digital support and connection
    collection
    language
    trust Score
    3
Citation snapshot and identifiers
id
youth-pmid-39666705
doi
10.1111/nyas.15266
pmid
39666705
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
citations By Collection
language
Not recorded
Complete approved library record
lab Relevance
relationship
direct-response
implication
Create inclusive, anti-bullying participation and monitor belonging; evaluate rather than assume a preventive effect.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
institutions
None recorded
institution Evidence
None recorded
research Topics

Youth needs / digital / access

publication Status
pmid
39666705
checked At
2026-11-02T01:32:46.771640+00:00
pub Types

research-article · Systematic Review · Journal Article

indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
randomized Study Unit Id
Not recorded
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-1144f5c0c94c
source Content Hash
1144f5c0c94c38574b81cddb671827f1c657852cf16efd5ab4fbf12c0a1a01ab
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs

https://pubmed.ncbi.nlm.nih.gov/39666705/ · https://doi.org/10.1111/nyas.15266 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11668506/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11668506/fullTextXML · https://api.crossref.org/works/10.1111%2Fnyas.15266

retrieved At
2026-11-02
study Family Id
publication-39666705
approaches

Youth needs / digital / access

id
youth-pmid-39666705
aliases
None recorded
title
A systematic review of longitudinal risk and protective factors for loneliness in youth.
journal
Annals of the New York Academy of Sciences
neurotransmitters
None recorded
year
2024
authors
Buecker S, Petersen K, Neuber A, Zheng Y, Hayes D, Qualter P.
design
Review / synthesis
kind
Review
identity Conflict
Not recorded
doi
10.1111/nyas.15266
pmid
39666705
urls

https://doi.org/10.1111/nyas.15266 · https://pubmed.ncbi.nlm.nih.gov/39666705/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11668506/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11668506/fullTextXML · https://api.crossref.org/works/10.1111%2Fnyas.15266

collections

language

categories

Methods & context

targets
None recorded
priority
1
quotes
None recorded
summary
Peer rejection/victimisation and several mental-health difficulties consistently preceded later loneliness; many proposed factors lacked replicated evidence.
limitation
Prospective association is not causal proof; measures, follow-up intervals and baseline adjustment vary.
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
study Design Assessment
category
review
is Randomized Controlled Trial
false
peer Reviewed
true
basis
Systematic review of longitudinal observational studies
masking Roles
Not applicable or not established from inspected methods; no masking inferred
sources

https://pubmed.ncbi.nlm.nih.gov/39666705/ · https://doi.org/10.1111/nyas.15266 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11668506/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11668506/fullTextXML · https://api.crossref.org/works/10.1111%2Fnyas.15266

review Scope
selected-methods
paper Trust Assessment
score
1
display Crosses
1
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
false
peer Reviewed
true
blinding
not-applicable
masking Roles
Not applicable or not established from inspected methods; no masking inferred
basis
Systematic review of longitudinal observational studies
sources

https://pubmed.ncbi.nlm.nih.gov/39666705/ · https://doi.org/10.1111/nyas.15266 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11668506/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11668506/fullTextXML · https://api.crossref.org/works/10.1111%2Fnyas.15266

assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
citations By Collection
language
Not recorded
topics
  1. key
    language:universal-mind-mobile-lab
    title
    Universal Mind Mobile Lab · Direct response and inspired by
    collection
    language
    trust Score
    3
  2. key
    language:youth-access-connection
    title
    Youth access, digital support and connection
    collection
    language
    trust Score
    3
journal Key
annalsofthenewyorkacademyofsciences
journal Label
Annals of the New York Academy of Sciences
chapter Entries
  1. id
    language-universal-mind-mobile-lab-youth-pmid-39666705
    aliases
    None recorded
    title
    A systematic review of longitudinal risk and protective factors for loneliness in youth.
    authors
    Buecker S, Petersen K, Neuber A, Zheng Y, Hayes D, Qualter P.
    year
    2024
    journal
    Annals of the New York Academy of Sciences
    doi
    10.1111/nyas.15266
    pmid
    39666705
    urls

    https://doi.org/10.1111/nyas.15266 · https://pubmed.ncbi.nlm.nih.gov/39666705/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11668506/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11668506/fullTextXML · https://api.crossref.org/works/10.1111%2Fnyas.15266

    collections

    language

    categories

    Methods & context

    targets
    None recorded
    neurotransmitters
    None recorded
    conditions
    None recorded
    condition Evidence
    None recorded
    age Groups

    children · adolescents · youth · adults

    age Population
    record Id
    youth-pmid-39666705
    collections

    language

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    children · adolescents · youth · adults

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    The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
    age Fit
    mixed-overlap
    source URL
    https://pubmed.ncbi.nlm.nih.gov/39666705/
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    classification Note
    Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
    community Matches
    None recorded
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    Review
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    Review / synthesis
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    approved-youth-20261102
    priority
    1
    quotes
    None recorded
    finding
    Peer rejection/victimisation and several mental-health difficulties consistently preceded later loneliness; many proposed factors lacked replicated evidence.
    summary
    Peer rejection/victimisation and several mental-health difficulties consistently preceded later loneliness; many proposed factors lacked replicated evidence.
    limitation
    Prospective association is not causal proof; measures, follow-up intervals and baseline adjustment vary.
    evidence
    evidence Type
    Review / synthesis
    intervention
    Not applicable or not established from inspected sections
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    sample
    105 articles
    population
    age
    Below 25, including children
    age Fit
    mixed-overlap
    sample
    105 articles
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    measurement
    Specific outcomes are reported in the finding and retained appraisal.
    trial Id
    publication-39666705
    trial Registries
    None recorded
    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    relationship Note
    Create inclusive, anti-bullying participation and monitor belonging; evaluate rather than assume a preventive effect. Component evidence does not establish efficacy of the combined Universal Mind lab model.
    measured Genes
    None recorded
    pathways
    None recorded
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
    false
    jadad Score
    Not recorded
    masking Roles
    Not applicable or not established from inspected methods; no masking inferred
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    source Access
    scope
    selected-methods
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    true
    methods Inspected
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    retrieved At
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    https://pubmed.ncbi.nlm.nih.gov/39666705/ · https://doi.org/10.1111/nyas.15266 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11668506/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11668506/fullTextXML · https://api.crossref.org/works/10.1111%2Fnyas.15266

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    assessed At
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    false
    review Limit
    AI source-based design assessment; human content sign-off is recorded separately.
    jadad
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    not-applicable
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    Not recorded
    citation Count
    Not recorded
    citation Snapshot
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    Not recorded
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    Not recorded
    retrieved At
    Not recorded
    status
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    approved-for-publication
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    Ben Korbel
    approved At
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    retrieved At
    2026-11-02
    study Family Id
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    randomized Study Unit Id
    Not recorded
    institutions
    None recorded
    institution Evidence
    None recorded
    research Topics

    Youth needs / digital / access

    lab Relevance
    relationship
    direct-response
    implication
    Create inclusive, anti-bullying participation and monitor belonging; evaluate rather than assume a preventive effect.
    transfer Limit
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    2026-11-02T01:32:46.771640+00:00
    pub Types

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    indexed Notices
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    crossref Updates
    None recorded
    notice Records
    None recorded
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
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    Youth needs / digital / access

    record Id
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    source Pages
    None recorded
    assessment Record
    id
    youth-pmid-39666705
    title
    A systematic review of longitudinal risk and protective factors for loneliness in youth.
    authors
    Buecker S, Petersen K, Neuber A, Zheng Y, Hayes D, Qualter P.
    year
    2024
    journal
    Annals of the New York Academy of Sciences
    doi
    10.1111/nyas.15266
    pmid
    39666705
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    Identifiers explicitly reported in article abstract; other registrations remain unverified
    collection
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    Youth needs / digital / access

    institutions
    None recorded
    institution Evidence
    None recorded
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    research-article · Systematic Review · Journal Article

    study Family Id
    publication-39666705
    randomized Study Unit Id
    Not recorded
    existing Repository Matches
    None recorded
    population
    age
    Below 25, including children
    age Fit
    mixed-overlap
    sample
    105 articles
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
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    approved Crosses
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    findings
    Peer rejection/victimisation and several mental-health difficulties consistently preceded later loneliness; many proposed factors lacked replicated evidence.
    limitations
    Prospective association is not causal proof; measures, follow-up intervals and baseline adjustment vary.
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    lab Relevance
    relationship
    direct-response
    implication
    Create inclusive, anti-bullying participation and monitor belonging; evaluate rather than assume a preventive effect.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
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    selected-methods
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    pub Types

    research-article · Systematic Review · Journal Article

    indexed Notices
    None recorded
    crossref Updates
    None recorded
    notice Records
    None recorded
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
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    Ben reviews proposed content and release; full medical-paper reading is not required.
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  2. id
    language-youth-access-connection-youth-pmid-39666705
    aliases
    None recorded
    title
    A systematic review of longitudinal risk and protective factors for loneliness in youth.
    authors
    Buecker S, Petersen K, Neuber A, Zheng Y, Hayes D, Qualter P.
    year
    2024
    journal
    Annals of the New York Academy of Sciences
    doi
    10.1111/nyas.15266
    pmid
    39666705
    urls

    https://doi.org/10.1111/nyas.15266 · https://pubmed.ncbi.nlm.nih.gov/39666705/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11668506/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11668506/fullTextXML · https://api.crossref.org/works/10.1111%2Fnyas.15266

    collections

    language

    categories

    Methods & context

    targets
    None recorded
    neurotransmitters
    None recorded
    conditions
    None recorded
    condition Evidence
    None recorded
    age Groups

    children · adolescents · youth · adults

    age Population
    record Id
    youth-pmid-39666705
    collections

    language

    groups

    children · adolescents · youth · adults

    reported Ages
    Below 25, including children
    youth Scope
    included
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    The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
    age Fit
    mixed-overlap
    source URL
    https://pubmed.ncbi.nlm.nih.gov/39666705/
    basis Type
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    Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
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    None recorded
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    Review
    design
    Review / synthesis
    origin
    approved-youth-20261102
    priority
    1
    quotes
    None recorded
    finding
    Peer rejection/victimisation and several mental-health difficulties consistently preceded later loneliness; many proposed factors lacked replicated evidence.
    summary
    Peer rejection/victimisation and several mental-health difficulties consistently preceded later loneliness; many proposed factors lacked replicated evidence.
    limitation
    Prospective association is not causal proof; measures, follow-up intervals and baseline adjustment vary.
    evidence
    evidence Type
    Review / synthesis
    intervention
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    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
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    See design/intervention description; otherwise unknown
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    Below 25, including children
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    mixed-overlap
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    Buecker S, Petersen K, Neuber A, Zheng Y, Hayes D, Qualter P.
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    Annals of the New York Academy of Sciences
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mixed-overlap
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Create inclusive, anti-bullying participation and monitor belonging; evaluate rather than assume a preventive effect. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
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Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
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retrieved At
2026-11-02
jadad
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conditions
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topic Trust Scores

3

full Text
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