Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm randomised controlled trial.

Torok M, McGillivray L, Gan DZQ, Han J, Hetrick S, Wong QJJ. · EClinicalMedicine · 2025 · Randomized controlled trial report · verified double blind

Original publication · Original publication · Original publication · Original publication · Original publication

Recorded summary

Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.

Recorded limitations

Specific clinical app and selected English-speaking smartphone users; ideation reduction does not establish prevention of suicide or whole-lab benefit; engagement comparison may be distinguishable.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment

design

Randomized controlled trial report · verified double blind

assessment

category: double-blind-rct
is Randomized Controlled Trial: true
peer Reviewed: true
basis: Double-blind three-arm randomised controlled trial
masking Roles: Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
sources: https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
review Scope: selected-methods

trust Factor

score: 3
display Crosses: 3
scope: Paper
status: assessed
rating Scale: library-trust-factor/1-3
randomized Controlled Trial: true
peer Reviewed: true
blinding: double
masking Roles: Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
basis: Double-blind three-arm randomised controlled trial
sources: https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
assessed At: 2026-11-02
review Scope: selected-methods
human Approval: false
review Limit: AI source-based design assessment; human content sign-off is recorded separately.

jadad

status: unassessed
score: Not recorded

evidence

evidence Type

Randomized controlled trial report · verified double blind

intervention

Third-wave CBT skills app with/without digital engagement resources versus attention-matched sham; 30/60/120-day assessments

provider

Not separately established; clinician/teacher/app details, if known, are retained in the intervention description

comparator

See design/intervention description; otherwise unknown

sample

692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app

population

age: 17–24; mean 19.9
age Fit: direct
sample: 692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
setting: Not separately established; see population/intervention description
community: Not assigned

measurement

Specific outcomes are reported in the finding and retained appraisal.

trial Id

lifebuoy-replication-2024

trial Registries

ACTRN12621001247864

registry Scope

Identifiers explicitly reported in article abstract; other registrations remain unverified

relationship Note

Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab. Component evidence does not establish efficacy of the combined Universal Mind lab model.

measured Genes

None recorded

pathways

None recorded

quality

tier: priority
qualification: Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied: false
jadad Score: Not recorded

masking Roles

Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.

harms And Attrition

Serious self-harm/attempt-related events reported by 6% overall (9% control, 4% combined intervention); no deaths. Do not infer a proven protective event-rate effect from descriptive figures.

source Access

scope: selected-methods
full Text Cached: true
methods Inspected: true
full Text Appraisal Claim: false
level: selected-methods
source URLs: https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
retrieved At: 2026-11-02

Topics and recorded topic scores

key
language:black-dog-youth
title
Black Dog Institute · Youth research
collection
language
trust Score
2
key
language:orygen-youth
title
Orygen · Youth research
collection
language
trust Score
2
key
language:universal-mind-mobile-lab
title
Universal Mind Mobile Lab · Direct response and inspired by
collection
language
trust Score
3
key
language:youth-access-connection
title
Youth access, digital support and connection
collection
language
trust Score
3

Citation snapshot and identifiers

id

youth-pmid-39720610

doi

10.1016/j.eclinm.2024.102963

pmid

39720610

citation Snapshot

count: Not recorded
source: Not recorded
retrieved At: Not recorded
status: not-assessed

citations By Collection

language: Not recorded

Complete approved library record

lab Relevance

relationship: inspired-by
implication: Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab.
transfer Limit: Component evidence does not establish efficacy of the combined Universal Mind lab model.

institutions

Black Dog Institute · Orygen

institution Evidence

institution
Black Dog Institute
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
University of New South Wales, Black Dog Institute, Sydney, Australia.
institution
Orygen
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
Orygen Centre for Youth Mental Health, Parkville, Australia.

research Topics

Youth needs / digital / access

publication Status

pmid: 39720610
checked At: 2026-11-02T01:32:46.771936+00:00
pub Types: research-article · Journal Article
indexed Notices: None recorded
crossref Updates: None recorded
notice Records: None recorded
scope: Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.

notice Summary

Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.

randomized Study Unit Id

lifebuoy-replication-2024

publication Approval

status: approved-for-publication
approved By: Ben Korbel
approved At: 2026-11-02
assessment: AI assessed; human approved for publication
scope: Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision: r1-98ae4f9206a8
source Content Hash: 98ae4f9206a8ab646c5fe9d1cd9ad983487cbca97db672b78404d00f5722a261

source Access

scope: selected-methods
full Text Cached: true
methods Inspected: true
full Text Appraisal Claim: false
level: selected-methods
source URLs: https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
retrieved At: 2026-11-02

study Family Id

publication-39720610

approaches

Youth needs / digital / access

id

youth-pmid-39720610

aliases

None recorded

title

Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm randomised controlled trial.

journal

EClinicalMedicine

neurotransmitters

None recorded

year

2025

authors

Torok M, McGillivray L, Gan DZQ, Han J, Hetrick S, Wong QJJ.

design

Randomized controlled trial report · verified double blind

kind

Journal article

identity Conflict

Not recorded

doi

10.1016/j.eclinm.2024.102963

pmid

39720610

urls

https://doi.org/10.1016/j.eclinm.2024.102963 · https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963

collections

language

categories

Clinical & self-report

targets

None recorded

priority

quotes

None recorded

summary

Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.

limitation

Specific clinical app and selected English-speaking smartphone users; ideation reduction does not establish prevention of suicide or whole-lab benefit; engagement comparison may be distinguishable.

citation Count

Not recorded

citation Snapshot

count: Not recorded
source: Not recorded
retrieved At: Not recorded
status: not-assessed

study Design Assessment

category: double-blind-rct
is Randomized Controlled Trial: true
peer Reviewed: true
basis: Double-blind three-arm randomised controlled trial
masking Roles: Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
sources: https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
review Scope: selected-methods

paper Trust Assessment

score: 3
display Crosses: 3
scope: Paper
status: assessed
rating Scale: library-trust-factor/1-3
randomized Controlled Trial: true
peer Reviewed: true
blinding: double
masking Roles: Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
basis: Double-blind three-arm randomised controlled trial
sources: https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
assessed At: 2026-11-02
review Scope: selected-methods
human Approval: false
review Limit: AI source-based design assessment; human content sign-off is recorded separately.

citations By Collection

language: Not recorded

topics

key
language:black-dog-youth
title
Black Dog Institute · Youth research
collection
language
trust Score
2
key
language:orygen-youth
title
Orygen · Youth research
collection
language
trust Score
2
key
language:universal-mind-mobile-lab
title
Universal Mind Mobile Lab · Direct response and inspired by
collection
language
trust Score
3
key
language:youth-access-connection
title
Youth access, digital support and connection
collection
language
trust Score
3

journal Key

eclinicalmedicine

journal Label

EClinicalMedicine

chapter Entries

id
language-black-dog-youth-youth-pmid-39720610
aliases
None recorded
title
Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm randomised controlled trial.
authors
Torok M, McGillivray L, Gan DZQ, Han J, Hetrick S, Wong QJJ.
year
2025
journal
EClinicalMedicine
doi
10.1016/j.eclinm.2024.102963
pmid
39720610
urls
https://doi.org/10.1016/j.eclinm.2024.102963 · https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
collections
language
categories
Clinical & self-report
targets
None recorded
neurotransmitters
None recorded
conditions
None recorded
condition Evidence
None recorded
age Groups
adolescents · youth · adults
age Population
record Id
youth-pmid-39720610
collections
language
groups
adolescents · youth · adults
reported Ages
17–24; mean 19.9
youth Scope
focus
youth Source Note
The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
age Fit
direct
source URL
https://pubmed.ncbi.nlm.nih.gov/39720610/
basis Type
selected-methods-ai-editorial-assessment
classification Note
Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
community Matches
None recorded
kind
Journal article
design
Randomized controlled trial report · verified double blind
origin
approved-youth-20261102
priority
1
quotes
None recorded
finding
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
summary
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
limitation
Specific clinical app and selected English-speaking smartphone users; ideation reduction does not establish prevention of suicide or whole-lab benefit; engagement comparison may be distinguishable.
evidence
evidence Type
Randomized controlled trial report · verified double blind
intervention
Third-wave CBT skills app with/without digital engagement resources versus attention-matched sham; 30/60/120-day assessments
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
population
age
17–24; mean 19.9
age Fit
direct
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
lifebuoy-replication-2024
trial Registries
ACTRN12621001247864
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
harms And Attrition
Serious self-harm/attempt-related events reported by 6% overall (9% control, 4% combined intervention); no deaths. Do not infer a proven protective event-rate effect from descriptive figures.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
retrieved At
2026-11-02
study Design Assessment
category
double-blind-rct
is Randomized Controlled Trial
true
peer Reviewed
true
basis
Double-blind three-arm randomised controlled trial
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
sources
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
review Scope
selected-methods
paper Trust Assessment
score
3
display Crosses
3
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
true
peer Reviewed
true
blinding
double
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
basis
Double-blind three-arm randomised controlled trial
sources
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
unassessed
score
Not recorded
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-98ae4f9206a8
source Content Hash
98ae4f9206a8ab646c5fe9d1cd9ad983487cbca97db672b78404d00f5722a261
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
retrieved At
2026-11-02
study Family Id
publication-39720610
randomized Study Unit Id
lifebuoy-replication-2024
institutions
Black Dog Institute · Orygen
institution Evidence
1. institution
  Black Dog Institute
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  University of New South Wales, Black Dog Institute, Sydney, Australia.
2. institution
  Orygen
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  Orygen Centre for Youth Mental Health, Parkville, Australia.
research Topics
Youth needs / digital / access
lab Relevance
relationship
inspired-by
implication
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
publication Status
pmid
39720610
checked At
2026-11-02T01:32:46.771936+00:00
pub Types
research-article · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
approaches
Youth needs / digital / access
record Id
youth-pmid-39720610
source Pages
None recorded
assessment Record
id
youth-pmid-39720610
title
Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm randomised controlled trial.
authors
Torok M, McGillivray L, Gan DZQ, Han J, Hetrick S, Wong QJJ.
year
2025
journal
EClinicalMedicine
doi
10.1016/j.eclinm.2024.102963
pmid
39720610
pmcid
PMC11665678
trial Registries
ACTRN12621001247864
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
collection
youth-20261102
topics
Youth needs / digital / access
institutions
Black Dog Institute · Orygen
institution Evidence
institution
Black Dog Institute
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
University of New South Wales, Black Dog Institute, Sydney, Australia.
institution
Orygen
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
Orygen Centre for Youth Mental Health, Parkville, Australia.
publication Type
research-article · Journal Article
study Family Id
publication-39720610
randomized Study Unit Id
lifebuoy-replication-2024
existing Repository Matches
None recorded
population
age
17–24; mean 19.9
age Fit
direct
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
setting
Not separately established; see population/intervention description
community
Not assigned
intervention
description And Dose
Third-wave CBT skills app with/without digital engagement resources versus attention-matched sham; 30/60/120-day assessments
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
design
description
Double-blind three-arm randomised controlled trial
category
randomized-report
randomization Methods Inspected
true
masking
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
double Blinding Verified
true
proposed Crosses
3
approved Crosses
Not recorded
findings
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
limitations
Specific clinical app and selected English-speaking smartphone users; ideation reduction does not establish prevention of suicide or whole-lab benefit; engagement comparison may be distinguishable.
harms And Attrition
Serious self-harm/attempt-related events reported by 6% overall (9% control, 4% combined intervention); no deaths. Do not infer a proven protective event-rate effect from descriptive figures.
lab Relevance
relationship
inspired-by
implication
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
sources
type
primary bibliographic record
url
https://pubmed.ncbi.nlm.nih.gov/39720610/
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2026-11-02
sha256
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hash Scope
normalized Europe PMC core metadata snapshot
type
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url
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2026-11-02
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pmid
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checked At
2026-11-02T01:32:46.771936+00:00
pub Types
research-article · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
review Ready
true
hold Reason
Not recorded
duplicate Of
Not recorded
review
status
pending
reviewer
Not recorded
approved At
Not recorded
decision Scope
Ben reviews proposed content and release; full medical-paper reading is not required.
provenance
Discovered and appraised by AI; pending human content sign-off
production Eligible
false
approved Retrieval Eligible
false
selected Corpus References
None recorded
reference Scope
Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
content Hash
98ae4f9206a8ab646c5fe9d1cd9ad983487cbca97db672b78404d00f5722a261
revision
r1-98ae4f9206a8
archive Entries
None recorded
collection
language
chapter Number
6
topic Id
black-dog-youth
topic Title
Black Dog Institute · Youth research
trust Score
2
id
language-orygen-youth-youth-pmid-39720610
aliases
None recorded
title
Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm randomised controlled trial.
authors
Torok M, McGillivray L, Gan DZQ, Han J, Hetrick S, Wong QJJ.
year
2025
journal
EClinicalMedicine
doi
10.1016/j.eclinm.2024.102963
pmid
39720610
urls
https://doi.org/10.1016/j.eclinm.2024.102963 · https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
collections
language
categories
Clinical & self-report
targets
None recorded
neurotransmitters
None recorded
conditions
None recorded
condition Evidence
None recorded
age Groups
adolescents · youth · adults
age Population
record Id
youth-pmid-39720610
collections
language
groups
adolescents · youth · adults
reported Ages
17–24; mean 19.9
youth Scope
focus
youth Source Note
The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
age Fit
direct
source URL
https://pubmed.ncbi.nlm.nih.gov/39720610/
basis Type
selected-methods-ai-editorial-assessment
classification Note
Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
community Matches
None recorded
kind
Journal article
design
Randomized controlled trial report · verified double blind
origin
approved-youth-20261102
priority
1
quotes
None recorded
finding
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
summary
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
limitation
Specific clinical app and selected English-speaking smartphone users; ideation reduction does not establish prevention of suicide or whole-lab benefit; engagement comparison may be distinguishable.
evidence
evidence Type
Randomized controlled trial report · verified double blind
intervention
Third-wave CBT skills app with/without digital engagement resources versus attention-matched sham; 30/60/120-day assessments
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
population
age
17–24; mean 19.9
age Fit
direct
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
lifebuoy-replication-2024
trial Registries
ACTRN12621001247864
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
harms And Attrition
Serious self-harm/attempt-related events reported by 6% overall (9% control, 4% combined intervention); no deaths. Do not infer a proven protective event-rate effect from descriptive figures.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
retrieved At
2026-11-02
study Design Assessment
category
double-blind-rct
is Randomized Controlled Trial
true
peer Reviewed
true
basis
Double-blind three-arm randomised controlled trial
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
sources
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
review Scope
selected-methods
paper Trust Assessment
score
3
display Crosses
3
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
true
peer Reviewed
true
blinding
double
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
basis
Double-blind three-arm randomised controlled trial
sources
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
unassessed
score
Not recorded
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-98ae4f9206a8
source Content Hash
98ae4f9206a8ab646c5fe9d1cd9ad983487cbca97db672b78404d00f5722a261
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
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full Text Appraisal Claim
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level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
retrieved At
2026-11-02
study Family Id
publication-39720610
randomized Study Unit Id
lifebuoy-replication-2024
institutions
Black Dog Institute · Orygen
institution Evidence
1. institution
  Black Dog Institute
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  University of New South Wales, Black Dog Institute, Sydney, Australia.
2. institution
  Orygen
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  Orygen Centre for Youth Mental Health, Parkville, Australia.
research Topics
Youth needs / digital / access
lab Relevance
relationship
inspired-by
implication
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
publication Status
pmid
39720610
checked At
2026-11-02T01:32:46.771936+00:00
pub Types
research-article · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
approaches
Youth needs / digital / access
record Id
youth-pmid-39720610
source Pages
None recorded
assessment Record
id
youth-pmid-39720610
title
Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm randomised controlled trial.
authors
Torok M, McGillivray L, Gan DZQ, Han J, Hetrick S, Wong QJJ.
year
2025
journal
EClinicalMedicine
doi
10.1016/j.eclinm.2024.102963
pmid
39720610
pmcid
PMC11665678
trial Registries
ACTRN12621001247864
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
collection
youth-20261102
topics
Youth needs / digital / access
institutions
Black Dog Institute · Orygen
institution Evidence
institution
Black Dog Institute
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
University of New South Wales, Black Dog Institute, Sydney, Australia.
institution
Orygen
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
Orygen Centre for Youth Mental Health, Parkville, Australia.
publication Type
research-article · Journal Article
study Family Id
publication-39720610
randomized Study Unit Id
lifebuoy-replication-2024
existing Repository Matches
None recorded
population
age
17–24; mean 19.9
age Fit
direct
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
setting
Not separately established; see population/intervention description
community
Not assigned
intervention
description And Dose
Third-wave CBT skills app with/without digital engagement resources versus attention-matched sham; 30/60/120-day assessments
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
design
description
Double-blind three-arm randomised controlled trial
category
randomized-report
randomization Methods Inspected
true
masking
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
double Blinding Verified
true
proposed Crosses
3
approved Crosses
Not recorded
findings
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
limitations
Specific clinical app and selected English-speaking smartphone users; ideation reduction does not establish prevention of suicide or whole-lab benefit; engagement comparison may be distinguishable.
harms And Attrition
Serious self-harm/attempt-related events reported by 6% overall (9% control, 4% combined intervention); no deaths. Do not infer a proven protective event-rate effect from descriptive figures.
lab Relevance
relationship
inspired-by
implication
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
sources
type
primary bibliographic record
url
https://pubmed.ncbi.nlm.nih.gov/39720610/
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2026-11-02
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checked At
2026-11-02T01:32:46.771936+00:00
pub Types
research-article · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
review Ready
true
hold Reason
Not recorded
duplicate Of
Not recorded
review
status
pending
reviewer
Not recorded
approved At
Not recorded
decision Scope
Ben reviews proposed content and release; full medical-paper reading is not required.
provenance
Discovered and appraised by AI; pending human content sign-off
production Eligible
false
approved Retrieval Eligible
false
selected Corpus References
None recorded
reference Scope
Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
content Hash
98ae4f9206a8ab646c5fe9d1cd9ad983487cbca97db672b78404d00f5722a261
revision
r1-98ae4f9206a8
archive Entries
None recorded
collection
language
chapter Number
6
topic Id
orygen-youth
topic Title
Orygen · Youth research
trust Score
2
id
language-universal-mind-mobile-lab-youth-pmid-39720610
aliases
None recorded
title
Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm randomised controlled trial.
authors
Torok M, McGillivray L, Gan DZQ, Han J, Hetrick S, Wong QJJ.
year
2025
journal
EClinicalMedicine
doi
10.1016/j.eclinm.2024.102963
pmid
39720610
urls
https://doi.org/10.1016/j.eclinm.2024.102963 · https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
collections
language
categories
Clinical & self-report
targets
None recorded
neurotransmitters
None recorded
conditions
None recorded
condition Evidence
None recorded
age Groups
adolescents · youth · adults
age Population
record Id
youth-pmid-39720610
collections
language
groups
adolescents · youth · adults
reported Ages
17–24; mean 19.9
youth Scope
focus
youth Source Note
The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
age Fit
direct
source URL
https://pubmed.ncbi.nlm.nih.gov/39720610/
basis Type
selected-methods-ai-editorial-assessment
classification Note
Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
community Matches
None recorded
kind
Journal article
design
Randomized controlled trial report · verified double blind
origin
approved-youth-20261102
priority
1
quotes
None recorded
finding
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
summary
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
limitation
Specific clinical app and selected English-speaking smartphone users; ideation reduction does not establish prevention of suicide or whole-lab benefit; engagement comparison may be distinguishable.
evidence
evidence Type
Randomized controlled trial report · verified double blind
intervention
Third-wave CBT skills app with/without digital engagement resources versus attention-matched sham; 30/60/120-day assessments
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
population
age
17–24; mean 19.9
age Fit
direct
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
lifebuoy-replication-2024
trial Registries
ACTRN12621001247864
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
harms And Attrition
Serious self-harm/attempt-related events reported by 6% overall (9% control, 4% combined intervention); no deaths. Do not infer a proven protective event-rate effect from descriptive figures.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
retrieved At
2026-11-02
study Design Assessment
category
double-blind-rct
is Randomized Controlled Trial
true
peer Reviewed
true
basis
Double-blind three-arm randomised controlled trial
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
sources
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
review Scope
selected-methods
paper Trust Assessment
score
3
display Crosses
3
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
true
peer Reviewed
true
blinding
double
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
basis
Double-blind three-arm randomised controlled trial
sources
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
unassessed
score
Not recorded
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-98ae4f9206a8
source Content Hash
98ae4f9206a8ab646c5fe9d1cd9ad983487cbca97db672b78404d00f5722a261
source Access
scope
selected-methods
full Text Cached
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methods Inspected
true
full Text Appraisal Claim
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level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
retrieved At
2026-11-02
study Family Id
publication-39720610
randomized Study Unit Id
lifebuoy-replication-2024
institutions
Black Dog Institute · Orygen
institution Evidence
1. institution
  Black Dog Institute
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  University of New South Wales, Black Dog Institute, Sydney, Australia.
2. institution
  Orygen
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  Orygen Centre for Youth Mental Health, Parkville, Australia.
research Topics
Youth needs / digital / access
lab Relevance
relationship
inspired-by
implication
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
publication Status
pmid
39720610
checked At
2026-11-02T01:32:46.771936+00:00
pub Types
research-article · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
approaches
Youth needs / digital / access
record Id
youth-pmid-39720610
source Pages
None recorded
assessment Record
id
youth-pmid-39720610
title
Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm randomised controlled trial.
authors
Torok M, McGillivray L, Gan DZQ, Han J, Hetrick S, Wong QJJ.
year
2025
journal
EClinicalMedicine
doi
10.1016/j.eclinm.2024.102963
pmid
39720610
pmcid
PMC11665678
trial Registries
ACTRN12621001247864
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
collection
youth-20261102
topics
Youth needs / digital / access
institutions
Black Dog Institute · Orygen
institution Evidence
institution
Black Dog Institute
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
University of New South Wales, Black Dog Institute, Sydney, Australia.
institution
Orygen
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
Orygen Centre for Youth Mental Health, Parkville, Australia.
publication Type
research-article · Journal Article
study Family Id
publication-39720610
randomized Study Unit Id
lifebuoy-replication-2024
existing Repository Matches
None recorded
population
age
17–24; mean 19.9
age Fit
direct
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
setting
Not separately established; see population/intervention description
community
Not assigned
intervention
description And Dose
Third-wave CBT skills app with/without digital engagement resources versus attention-matched sham; 30/60/120-day assessments
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
design
description
Double-blind three-arm randomised controlled trial
category
randomized-report
randomization Methods Inspected
true
masking
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
double Blinding Verified
true
proposed Crosses
3
approved Crosses
Not recorded
findings
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
limitations
Specific clinical app and selected English-speaking smartphone users; ideation reduction does not establish prevention of suicide or whole-lab benefit; engagement comparison may be distinguishable.
harms And Attrition
Serious self-harm/attempt-related events reported by 6% overall (9% control, 4% combined intervention); no deaths. Do not infer a proven protective event-rate effect from descriptive figures.
lab Relevance
relationship
inspired-by
implication
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
sources
type
primary bibliographic record
url
https://pubmed.ncbi.nlm.nih.gov/39720610/
retrieved At
2026-11-02
sha256
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publisher DOI
url
https://doi.org/10.1016/j.eclinm.2024.102963
retrieved At
2026-11-02
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https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/
retrieved At
2026-11-02
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2026-11-02T00:59:08.193540+00:00
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url
https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
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pmid
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checked At
2026-11-02T01:32:46.771936+00:00
pub Types
research-article · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
review Ready
true
hold Reason
Not recorded
duplicate Of
Not recorded
review
status
pending
reviewer
Not recorded
approved At
Not recorded
decision Scope
Ben reviews proposed content and release; full medical-paper reading is not required.
provenance
Discovered and appraised by AI; pending human content sign-off
production Eligible
false
approved Retrieval Eligible
false
selected Corpus References
None recorded
reference Scope
Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
content Hash
98ae4f9206a8ab646c5fe9d1cd9ad983487cbca97db672b78404d00f5722a261
revision
r1-98ae4f9206a8
archive Entries
None recorded
collection
language
chapter Number
6
topic Id
universal-mind-mobile-lab
topic Title
Universal Mind Mobile Lab · Direct response and inspired by
trust Score
3
id
language-youth-access-connection-youth-pmid-39720610
aliases
None recorded
title
Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm randomised controlled trial.
authors
Torok M, McGillivray L, Gan DZQ, Han J, Hetrick S, Wong QJJ.
year
2025
journal
EClinicalMedicine
doi
10.1016/j.eclinm.2024.102963
pmid
39720610
urls
https://doi.org/10.1016/j.eclinm.2024.102963 · https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
collections
language
categories
Clinical & self-report
targets
None recorded
neurotransmitters
None recorded
conditions
None recorded
condition Evidence
None recorded
age Groups
adolescents · youth · adults
age Population
record Id
youth-pmid-39720610
collections
language
groups
adolescents · youth · adults
reported Ages
17–24; mean 19.9
youth Scope
focus
youth Source Note
The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
age Fit
direct
source URL
https://pubmed.ncbi.nlm.nih.gov/39720610/
basis Type
selected-methods-ai-editorial-assessment
classification Note
Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
community Matches
None recorded
kind
Journal article
design
Randomized controlled trial report · verified double blind
origin
approved-youth-20261102
priority
1
quotes
None recorded
finding
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
summary
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
limitation
Specific clinical app and selected English-speaking smartphone users; ideation reduction does not establish prevention of suicide or whole-lab benefit; engagement comparison may be distinguishable.
evidence
evidence Type
Randomized controlled trial report · verified double blind
intervention
Third-wave CBT skills app with/without digital engagement resources versus attention-matched sham; 30/60/120-day assessments
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
population
age
17–24; mean 19.9
age Fit
direct
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
lifebuoy-replication-2024
trial Registries
ACTRN12621001247864
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
harms And Attrition
Serious self-harm/attempt-related events reported by 6% overall (9% control, 4% combined intervention); no deaths. Do not infer a proven protective event-rate effect from descriptive figures.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
retrieved At
2026-11-02
study Design Assessment
category
double-blind-rct
is Randomized Controlled Trial
true
peer Reviewed
true
basis
Double-blind three-arm randomised controlled trial
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
sources
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
review Scope
selected-methods
paper Trust Assessment
score
3
display Crosses
3
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
true
peer Reviewed
true
blinding
double
masking Roles
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
basis
Double-blind three-arm randomised controlled trial
sources
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
unassessed
score
Not recorded
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-98ae4f9206a8
source Content Hash
98ae4f9206a8ab646c5fe9d1cd9ad983487cbca97db672b78404d00f5722a261
source Access
scope
selected-methods
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true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
retrieved At
2026-11-02
study Family Id
publication-39720610
randomized Study Unit Id
lifebuoy-replication-2024
institutions
Black Dog Institute · Orygen
institution Evidence
1. institution
  Black Dog Institute
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  University of New South Wales, Black Dog Institute, Sydney, Australia.
2. institution
  Orygen
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  Orygen Centre for Youth Mental Health, Parkville, Australia.
research Topics
Youth needs / digital / access
lab Relevance
relationship
inspired-by
implication
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
publication Status
pmid
39720610
checked At
2026-11-02T01:32:46.771936+00:00
pub Types
research-article · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
approaches
Youth needs / digital / access
record Id
youth-pmid-39720610
source Pages
None recorded
assessment Record
id
youth-pmid-39720610
title
Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm randomised controlled trial.
authors
Torok M, McGillivray L, Gan DZQ, Han J, Hetrick S, Wong QJJ.
year
2025
journal
EClinicalMedicine
doi
10.1016/j.eclinm.2024.102963
pmid
39720610
pmcid
PMC11665678
trial Registries
ACTRN12621001247864
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
collection
youth-20261102
topics
Youth needs / digital / access
institutions
Black Dog Institute · Orygen
institution Evidence
institution
Black Dog Institute
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
University of New South Wales, Black Dog Institute, Sydney, Australia.
institution
Orygen
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
Orygen Centre for Youth Mental Health, Parkville, Australia.
publication Type
research-article · Journal Article
study Family Id
publication-39720610
randomized Study Unit Id
lifebuoy-replication-2024
existing Repository Matches
None recorded
population
age
17–24; mean 19.9
age Fit
direct
sample
692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
setting
Not separately established; see population/intervention description
community
Not assigned
intervention
description And Dose
Third-wave CBT skills app with/without digital engagement resources versus attention-matched sham; 30/60/120-day assessments
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
design
description
Double-blind three-arm randomised controlled trial
category
randomized-report
randomization Methods Inspected
true
masking
Computer blocks; both apps labelled LifeBuoy; participants unaware condition, all investigators including analyst masked. Verified participant and investigator masking for active-app versus sham comparison.
double Blinding Verified
true
proposed Crosses
3
approved Crosses
Not recorded
findings
Combined active arms reduced suicidal-ideation severity at 60 days (d=.48) and 120 days (d=.29), not 30 days. Extra engagement resources did not improve module completion or efficacy.
limitations
Specific clinical app and selected English-speaking smartphone users; ideation reduction does not establish prevention of suicide or whole-lab benefit; engagement comparison may be distinguishable.
harms And Attrition
Serious self-harm/attempt-related events reported by 6% overall (9% control, 4% combined intervention); no deaths. Do not infer a proven protective event-rate effect from descriptive figures.
lab Relevance
relationship
inspired-by
implication
Strong age-specific evidence for a particular supported self-management tool and careful safety monitoring; informs referral-linked design rather than validating the lab.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
sources
type
primary bibliographic record
url
https://pubmed.ncbi.nlm.nih.gov/39720610/
retrieved At
2026-11-02
sha256
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hash Scope
normalized Europe PMC core metadata snapshot
type
publisher DOI
url
https://doi.org/10.1016/j.eclinm.2024.102963
retrieved At
2026-11-02
type
PMC article
url
https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/
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access
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full-text-xml
url
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML
retrieved At
2026-11-02T00:59:08.193540+00:00
sha256
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url
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sha256
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pmid
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checked At
2026-11-02T01:32:46.771936+00:00
pub Types
research-article · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
review Ready
true
hold Reason
Not recorded
duplicate Of
Not recorded
review
status
pending
reviewer
Not recorded
approved At
Not recorded
decision Scope
Ben reviews proposed content and release; full medical-paper reading is not required.
provenance
Discovered and appraised by AI; pending human content sign-off
production Eligible
false
approved Retrieval Eligible
false
selected Corpus References
None recorded
reference Scope
Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
content Hash
98ae4f9206a8ab646c5fe9d1cd9ad983487cbca97db672b78404d00f5722a261
revision
r1-98ae4f9206a8
archive Entries
None recorded
collection
language
chapter Number
6
topic Id
youth-access-connection
topic Title
Youth access, digital support and connection
trust Score
3

evidence

evidence Type

Randomized controlled trial report · verified double blind

intervention

Third-wave CBT skills app with/without digital engagement resources versus attention-matched sham; 30/60/120-day assessments

provider

Not separately established; clinician/teacher/app details, if known, are retained in the intervention description

comparator

See design/intervention description; otherwise unknown

sample

692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app

population

age: 17–24; mean 19.9
age Fit: direct
sample: 692; 230 LifeBuoy, 229 LifeBuoy plus engagement, 233 sham app
setting: Not separately established; see population/intervention description
community: Not assigned

measurement

Specific outcomes are reported in the finding and retained appraisal.

trial Id

lifebuoy-replication-2024

trial Registries

ACTRN12621001247864

registry Scope

Identifiers explicitly reported in article abstract; other registrations remain unverified

relationship Note

measured Genes

None recorded

pathways

None recorded

quality

tier: priority
qualification: Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied: false
jadad Score: Not recorded

masking Roles

harms And Attrition

Serious self-harm/attempt-related events reported by 6% overall (9% control, 4% combined intervention); no deaths. Do not infer a proven protective event-rate effect from descriptive figures.

source Access

scope: selected-methods
full Text Cached: true
methods Inspected: true
full Text Appraisal Claim: false
level: selected-methods
source URLs: https://pubmed.ncbi.nlm.nih.gov/39720610/ · https://doi.org/10.1016/j.eclinm.2024.102963 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11665678/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11665678/fullTextXML · https://api.crossref.org/works/10.1016%2Fj.eclinm.2024.102963
retrieved At: 2026-11-02

jadad

status: unassessed
score: Not recorded

condition Evidence

None recorded

conditions

None recorded

topic Trust Scores

2 · 3

full Text

status: not-indexed
retrieval Available: false

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