Universal Informatics · Research reading room

Low-Intensity Online Intervention for Mental Distress Among Help-Seeking Young People in Hong Kong: A Randomized Clinical Trial.

Suen YN, Hui CLM, Lei LKS, Leung CM, Wong SMY, Lai GCH, Chau EHS, Wong MTH, Chan SKW, Wong GHY, Chen EYH. · JAMA network open · 2025 · Randomized controlled trial report · double blinding not verified

Original publication · Original publication · Original publication · Original publication · Original publication

Recorded summary

Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.

Recorded limitations

Missing data sensitivity, short follow-up and multiple outcomes; cannot present secondary signals as robust efficacy.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Randomized controlled trial report · double blinding not verified
assessment
category
rct-masking-unclear
is Randomized Controlled Trial
true
peer Reviewed
true
basis
Randomised controlled trial
masking Roles
Qualtrics variable blocks; participants unmasked.
sources

https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

review Scope
selected-methods
trust Factor
score
2
display Crosses
2
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
true
peer Reviewed
true
blinding
not-confirmed
masking Roles
Qualtrics variable blocks; participants unmasked.
basis
Randomised controlled trial
sources

https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
unassessed
score
Not recorded
evidence
evidence Type
Randomized controlled trial report · double blinding not verified
intervention
Four weekly 45–60-minute online practitioner sessions on stress, sleep or problem-solving versus self-help tips
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
120
population
age
Eligibility 12–30; mean 22.4 (SD 3.4)
age Fit
mixed-overlap
sample
120
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
publication-39813032
trial Registries

NCT05510453

registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
qualified
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Qualtrics variable blocks; participants unmasked.
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs

https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

retrieved At
2026-11-02
Topics and recorded topic scores
  1. key
    language:orygen-youth
    title
    Orygen · Youth research
    collection
    language
    trust Score
    2
  2. key
    language:universal-mind-mobile-lab
    title
    Universal Mind Mobile Lab · Direct response and inspired by
    collection
    language
    trust Score
    3
  3. key
    language:youth-access-connection
    title
    Youth access, digital support and connection
    collection
    language
    trust Score
    3
Citation snapshot and identifiers
id
youth-pmid-39813032
doi
10.1001/jamanetworkopen.2024.54675
pmid
39813032
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
citations By Collection
language
Not recorded
Complete approved library record
lab Relevance
relationship
limits
implication
Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
institutions

Orygen · headspace services

institution Evidence
  1. institution
    Orygen
    basis
    Author affiliation in primary indexed metadata or publisher full text
    evidence
    Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Parkville, Australia.
  2. institution
    headspace services
    basis
    Named service context/participating setting in inspected paper; not partnership with Universal Mind
research Topics

Youth needs / digital / access

publication Status
pmid
39813032
checked At
2026-11-02T01:32:46.773261+00:00
pub Types

Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article

indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
randomized Study Unit Id
publication-39813032
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-67b617ec33bb
source Content Hash
67b617ec33bb697399e137f23535d7922aae152b7b6dc34a959c3a520e6ec6ba
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs

https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

retrieved At
2026-11-02
study Family Id
publication-39813032
approaches

Youth needs / digital / access

id
youth-pmid-39813032
aliases
None recorded
title
Low-Intensity Online Intervention for Mental Distress Among Help-Seeking Young People in Hong Kong: A Randomized Clinical Trial.
journal
JAMA network open
neurotransmitters
None recorded
year
2025
authors
Suen YN, Hui CLM, Lei LKS, Leung CM, Wong SMY, Lai GCH, Chau EHS, Wong MTH, Chan SKW, Wong GHY, Chen EYH.
design
Randomized controlled trial report · double blinding not verified
kind
Journal article
identity Conflict
Not recorded
doi
10.1001/jamanetworkopen.2024.54675
pmid
39813032
urls

https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

collections

language

categories

Clinical & self-report

targets
None recorded
priority
1
quotes
None recorded
summary
Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
limitation
Missing data sensitivity, short follow-up and multiple outcomes; cannot present secondary signals as robust efficacy.
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
study Design Assessment
category
rct-masking-unclear
is Randomized Controlled Trial
true
peer Reviewed
true
basis
Randomised controlled trial
masking Roles
Qualtrics variable blocks; participants unmasked.
sources

https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

review Scope
selected-methods
paper Trust Assessment
score
2
display Crosses
2
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
true
peer Reviewed
true
blinding
not-confirmed
masking Roles
Qualtrics variable blocks; participants unmasked.
basis
Randomised controlled trial
sources

https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
citations By Collection
language
Not recorded
topics
  1. key
    language:orygen-youth
    title
    Orygen · Youth research
    collection
    language
    trust Score
    2
  2. key
    language:universal-mind-mobile-lab
    title
    Universal Mind Mobile Lab · Direct response and inspired by
    collection
    language
    trust Score
    3
  3. key
    language:youth-access-connection
    title
    Youth access, digital support and connection
    collection
    language
    trust Score
    3
journal Key
jamanetworkopen
journal Label
JAMA network open
chapter Entries
  1. id
    language-orygen-youth-youth-pmid-39813032
    aliases
    None recorded
    title
    Low-Intensity Online Intervention for Mental Distress Among Help-Seeking Young People in Hong Kong: A Randomized Clinical Trial.
    authors
    Suen YN, Hui CLM, Lei LKS, Leung CM, Wong SMY, Lai GCH, Chau EHS, Wong MTH, Chan SKW, Wong GHY, Chen EYH.
    year
    2025
    journal
    JAMA network open
    doi
    10.1001/jamanetworkopen.2024.54675
    pmid
    39813032
    urls

    https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    collections

    language

    categories

    Clinical & self-report

    targets
    None recorded
    neurotransmitters
    None recorded
    conditions

    anxiety · depression · stress

    condition Evidence
    1. id
      anxiety
      evidence
      1. field
        findings
        text
        Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
        matched Text
        anxiety
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    2. id
      depression
      evidence
      1. field
        findings
        text
        Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
        matched Text
        depression
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    3. id
      stress
      evidence
      1. field
        findings
        text
        Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
        matched Text
        stress
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    age Groups

    adolescents · youth · adults

    age Population
    record Id
    youth-pmid-39813032
    collections

    language

    groups

    adolescents · youth · adults

    reported Ages
    Eligibility 12–30; mean 22.4 (SD 3.4)
    youth Scope
    included
    youth Source Note
    The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
    age Fit
    mixed-overlap
    source URL
    https://pubmed.ncbi.nlm.nih.gov/39813032/
    basis Type
    selected-methods-ai-editorial-assessment
    classification Note
    Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
    community Matches
    None recorded
    kind
    Journal article
    design
    Randomized controlled trial report · double blinding not verified
    origin
    approved-youth-20261102
    priority
    1
    quotes
    None recorded
    finding
    Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
    summary
    Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
    limitation
    Missing data sensitivity, short follow-up and multiple outcomes; cannot present secondary signals as robust efficacy.
    evidence
    evidence Type
    Randomized controlled trial report · double blinding not verified
    intervention
    Four weekly 45–60-minute online practitioner sessions on stress, sleep or problem-solving versus self-help tips
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    sample
    120
    population
    age
    Eligibility 12–30; mean 22.4 (SD 3.4)
    age Fit
    mixed-overlap
    sample
    120
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    measurement
    Specific outcomes are reported in the finding and retained appraisal.
    trial Id
    publication-39813032
    trial Registries

    NCT05510453

    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    relationship Note
    Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit. Component evidence does not establish efficacy of the combined Universal Mind lab model.
    measured Genes
    None recorded
    pathways
    None recorded
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
    false
    jadad Score
    Not recorded
    masking Roles
    Qualtrics variable blocks; participants unmasked.
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    level
    selected-methods
    source URLs

    https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    retrieved At
    2026-11-02
    study Design Assessment
    category
    rct-masking-unclear
    is Randomized Controlled Trial
    true
    peer Reviewed
    true
    basis
    Randomised controlled trial
    masking Roles
    Qualtrics variable blocks; participants unmasked.
    sources

    https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    review Scope
    selected-methods
    paper Trust Assessment
    score
    2
    display Crosses
    2
    scope
    Paper
    status
    assessed
    rating Scale
    library-trust-factor/1-3
    randomized Controlled Trial
    true
    peer Reviewed
    true
    blinding
    not-confirmed
    masking Roles
    Qualtrics variable blocks; participants unmasked.
    basis
    Randomised controlled trial
    sources

    https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    assessed At
    2026-11-02
    review Scope
    selected-methods
    human Approval
    false
    review Limit
    AI source-based design assessment; human content sign-off is recorded separately.
    jadad
    status
    unassessed
    score
    Not recorded
    citation Count
    Not recorded
    citation Snapshot
    count
    Not recorded
    source
    Not recorded
    retrieved At
    Not recorded
    status
    not-assessed
    publication Approval
    status
    approved-for-publication
    approved By
    Ben Korbel
    approved At
    2026-11-02
    assessment
    AI assessed; human approved for publication
    scope
    Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
    source Revision
    r1-67b617ec33bb
    source Content Hash
    67b617ec33bb697399e137f23535d7922aae152b7b6dc34a959c3a520e6ec6ba
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    level
    selected-methods
    source URLs

    https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    retrieved At
    2026-11-02
    study Family Id
    publication-39813032
    randomized Study Unit Id
    publication-39813032
    institutions

    Orygen · headspace services

    institution Evidence
    1. institution
      Orygen
      basis
      Author affiliation in primary indexed metadata or publisher full text
      evidence
      Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Parkville, Australia.
    2. institution
      headspace services
      basis
      Named service context/participating setting in inspected paper; not partnership with Universal Mind
    research Topics

    Youth needs / digital / access

    lab Relevance
    relationship
    limits
    implication
    Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
    publication Status
    pmid
    39813032
    checked At
    2026-11-02T01:32:46.773261+00:00
    pub Types

    Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article

    indexed Notices
    None recorded
    crossref Updates
    None recorded
    notice Records
    None recorded
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
    approaches

    Youth needs / digital / access

    record Id
    youth-pmid-39813032
    source Pages
    None recorded
    assessment Record
    id
    youth-pmid-39813032
    title
    Low-Intensity Online Intervention for Mental Distress Among Help-Seeking Young People in Hong Kong: A Randomized Clinical Trial.
    authors
    Suen YN, Hui CLM, Lei LKS, Leung CM, Wong SMY, Lai GCH, Chau EHS, Wong MTH, Chan SKW, Wong GHY, Chen EYH.
    year
    2025
    journal
    JAMA network open
    doi
    10.1001/jamanetworkopen.2024.54675
    pmid
    39813032
    pmcid
    PMC11736507
    trial Registries

    NCT05510453

    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    collection
    youth-20261102
    topics

    Youth needs / digital / access

    institutions

    Orygen · headspace services

    institution Evidence
    1. institution
      Orygen
      basis
      Author affiliation in primary indexed metadata or publisher full text
      evidence
      Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Parkville, Australia.
    2. institution
      headspace services
      basis
      Named service context/participating setting in inspected paper; not partnership with Universal Mind
    publication Type

    Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article

    study Family Id
    publication-39813032
    randomized Study Unit Id
    publication-39813032
    existing Repository Matches
    None recorded
    population
    age
    Eligibility 12–30; mean 22.4 (SD 3.4)
    age Fit
    mixed-overlap
    sample
    120
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    intervention
    description And Dose
    Four weekly 45–60-minute online practitioner sessions on stress, sleep or problem-solving versus self-help tips
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    design
    description
    Randomised controlled trial
    category
    randomized-report
    randomization Methods Inspected
    true
    masking
    Qualtrics variable blocks; participants unmasked.
    double Blinding Verified
    false
    proposed Crosses
    2
    approved Crosses
    Not recorded
    findings
    Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
    limitations
    Missing data sensitivity, short follow-up and multiple outcomes; cannot present secondary signals as robust efficacy.
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    lab Relevance
    relationship
    limits
    implication
    Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    sources
    1. type
      primary bibliographic record
      url
      https://pubmed.ncbi.nlm.nih.gov/39813032/
      retrieved At
      2026-11-02
      sha256
      8f021861725aecc9fe70532b7af7c2c30474d6bccb2ba41783a7f52e2a669233
      hash Scope
      normalized Europe PMC core metadata snapshot
    2. type
      publisher DOI
      url
      https://doi.org/10.1001/jamanetworkopen.2024.54675
      retrieved At
      2026-11-02
    3. type
      PMC article
      url
      https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/
      retrieved At
      2026-11-02
      access
      Full text cached
    4. type
      full-text-xml
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML
      retrieved At
      2026-11-02T00:59:11.357692+00:00
      sha256
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      DOI-metadata
      url
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      retrieved At
      2026-11-02T00:59:12.431817+00:00
      sha256
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    publication Status
    pmid
    39813032
    checked At
    2026-11-02T01:32:46.773261+00:00
    pub Types

    Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article

    indexed Notices
    None recorded
    crossref Updates
    None recorded
    notice Records
    None recorded
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
    false
    jadad Score
    Not recorded
    review Ready
    true
    hold Reason
    Not recorded
    duplicate Of
    Not recorded
    review
    status
    pending
    reviewer
    Not recorded
    approved At
    Not recorded
    decision Scope
    Ben reviews proposed content and release; full medical-paper reading is not required.
    provenance
    Discovered and appraised by AI; pending human content sign-off
    production Eligible
    false
    approved Retrieval Eligible
    false
    selected Corpus References
    None recorded
    reference Scope
    Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
    content Hash
    67b617ec33bb697399e137f23535d7922aae152b7b6dc34a959c3a520e6ec6ba
    revision
    r1-67b617ec33bb
    archive Entries
    None recorded
    collection
    language
    chapter Number
    6
    topic Id
    orygen-youth
    topic Title
    Orygen · Youth research
    trust Score
    2
  2. id
    language-universal-mind-mobile-lab-youth-pmid-39813032
    aliases
    None recorded
    title
    Low-Intensity Online Intervention for Mental Distress Among Help-Seeking Young People in Hong Kong: A Randomized Clinical Trial.
    authors
    Suen YN, Hui CLM, Lei LKS, Leung CM, Wong SMY, Lai GCH, Chau EHS, Wong MTH, Chan SKW, Wong GHY, Chen EYH.
    year
    2025
    journal
    JAMA network open
    doi
    10.1001/jamanetworkopen.2024.54675
    pmid
    39813032
    urls

    https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    collections

    language

    categories

    Clinical & self-report

    targets
    None recorded
    neurotransmitters
    None recorded
    conditions

    anxiety · depression · stress

    condition Evidence
    1. id
      anxiety
      evidence
      1. field
        findings
        text
        Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
        matched Text
        anxiety
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    2. id
      depression
      evidence
      1. field
        findings
        text
        Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
        matched Text
        depression
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    3. id
      stress
      evidence
      1. field
        findings
        text
        Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
        matched Text
        stress
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    age Groups

    adolescents · youth · adults

    age Population
    record Id
    youth-pmid-39813032
    collections

    language

    groups

    adolescents · youth · adults

    reported Ages
    Eligibility 12–30; mean 22.4 (SD 3.4)
    youth Scope
    included
    youth Source Note
    The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
    age Fit
    mixed-overlap
    source URL
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    basis Type
    selected-methods-ai-editorial-assessment
    classification Note
    Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
    community Matches
    None recorded
    kind
    Journal article
    design
    Randomized controlled trial report · double blinding not verified
    origin
    approved-youth-20261102
    priority
    1
    quotes
    None recorded
    finding
    Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
    summary
    Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
    limitation
    Missing data sensitivity, short follow-up and multiple outcomes; cannot present secondary signals as robust efficacy.
    evidence
    evidence Type
    Randomized controlled trial report · double blinding not verified
    intervention
    Four weekly 45–60-minute online practitioner sessions on stress, sleep or problem-solving versus self-help tips
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    sample
    120
    population
    age
    Eligibility 12–30; mean 22.4 (SD 3.4)
    age Fit
    mixed-overlap
    sample
    120
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    measurement
    Specific outcomes are reported in the finding and retained appraisal.
    trial Id
    publication-39813032
    trial Registries

    NCT05510453

    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    relationship Note
    Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit. Component evidence does not establish efficacy of the combined Universal Mind lab model.
    measured Genes
    None recorded
    pathways
    None recorded
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
    false
    jadad Score
    Not recorded
    masking Roles
    Qualtrics variable blocks; participants unmasked.
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    level
    selected-methods
    source URLs

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    retrieved At
    2026-11-02
    study Design Assessment
    category
    rct-masking-unclear
    is Randomized Controlled Trial
    true
    peer Reviewed
    true
    basis
    Randomised controlled trial
    masking Roles
    Qualtrics variable blocks; participants unmasked.
    sources

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    review Scope
    selected-methods
    paper Trust Assessment
    score
    2
    display Crosses
    2
    scope
    Paper
    status
    assessed
    rating Scale
    library-trust-factor/1-3
    randomized Controlled Trial
    true
    peer Reviewed
    true
    blinding
    not-confirmed
    masking Roles
    Qualtrics variable blocks; participants unmasked.
    basis
    Randomised controlled trial
    sources

    https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    assessed At
    2026-11-02
    review Scope
    selected-methods
    human Approval
    false
    review Limit
    AI source-based design assessment; human content sign-off is recorded separately.
    jadad
    status
    unassessed
    score
    Not recorded
    citation Count
    Not recorded
    citation Snapshot
    count
    Not recorded
    source
    Not recorded
    retrieved At
    Not recorded
    status
    not-assessed
    publication Approval
    status
    approved-for-publication
    approved By
    Ben Korbel
    approved At
    2026-11-02
    assessment
    AI assessed; human approved for publication
    scope
    Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
    source Revision
    r1-67b617ec33bb
    source Content Hash
    67b617ec33bb697399e137f23535d7922aae152b7b6dc34a959c3a520e6ec6ba
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    level
    selected-methods
    source URLs

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    retrieved At
    2026-11-02
    study Family Id
    publication-39813032
    randomized Study Unit Id
    publication-39813032
    institutions

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    institution Evidence
    1. institution
      Orygen
      basis
      Author affiliation in primary indexed metadata or publisher full text
      evidence
      Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Parkville, Australia.
    2. institution
      headspace services
      basis
      Named service context/participating setting in inspected paper; not partnership with Universal Mind
    research Topics

    Youth needs / digital / access

    lab Relevance
    relationship
    limits
    implication
    Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
    publication Status
    pmid
    39813032
    checked At
    2026-11-02T01:32:46.773261+00:00
    pub Types

    Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article

    indexed Notices
    None recorded
    crossref Updates
    None recorded
    notice Records
    None recorded
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
    approaches

    Youth needs / digital / access

    record Id
    youth-pmid-39813032
    source Pages
    None recorded
    assessment Record
    id
    youth-pmid-39813032
    title
    Low-Intensity Online Intervention for Mental Distress Among Help-Seeking Young People in Hong Kong: A Randomized Clinical Trial.
    authors
    Suen YN, Hui CLM, Lei LKS, Leung CM, Wong SMY, Lai GCH, Chau EHS, Wong MTH, Chan SKW, Wong GHY, Chen EYH.
    year
    2025
    journal
    JAMA network open
    doi
    10.1001/jamanetworkopen.2024.54675
    pmid
    39813032
    pmcid
    PMC11736507
    trial Registries

    NCT05510453

    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    collection
    youth-20261102
    topics

    Youth needs / digital / access

    institutions

    Orygen · headspace services

    institution Evidence
    1. institution
      Orygen
      basis
      Author affiliation in primary indexed metadata or publisher full text
      evidence
      Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Parkville, Australia.
    2. institution
      headspace services
      basis
      Named service context/participating setting in inspected paper; not partnership with Universal Mind
    publication Type

    Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article

    study Family Id
    publication-39813032
    randomized Study Unit Id
    publication-39813032
    existing Repository Matches
    None recorded
    population
    age
    Eligibility 12–30; mean 22.4 (SD 3.4)
    age Fit
    mixed-overlap
    sample
    120
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    intervention
    description And Dose
    Four weekly 45–60-minute online practitioner sessions on stress, sleep or problem-solving versus self-help tips
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    design
    description
    Randomised controlled trial
    category
    randomized-report
    randomization Methods Inspected
    true
    masking
    Qualtrics variable blocks; participants unmasked.
    double Blinding Verified
    false
    proposed Crosses
    2
    approved Crosses
    Not recorded
    findings
    Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
    limitations
    Missing data sensitivity, short follow-up and multiple outcomes; cannot present secondary signals as robust efficacy.
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    lab Relevance
    relationship
    limits
    implication
    Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    sources
    1. type
      primary bibliographic record
      url
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      retrieved At
      2026-11-02
      sha256
      8f021861725aecc9fe70532b7af7c2c30474d6bccb2ba41783a7f52e2a669233
      hash Scope
      normalized Europe PMC core metadata snapshot
    2. type
      publisher DOI
      url
      https://doi.org/10.1001/jamanetworkopen.2024.54675
      retrieved At
      2026-11-02
    3. type
      PMC article
      url
      https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/
      retrieved At
      2026-11-02
      access
      Full text cached
    4. type
      full-text-xml
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML
      retrieved At
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      sha256
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    5. type
      DOI-metadata
      url
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      retrieved At
      2026-11-02T00:59:12.431817+00:00
      sha256
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    publication Status
    pmid
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    checked At
    2026-11-02T01:32:46.773261+00:00
    pub Types

    Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article

    indexed Notices
    None recorded
    crossref Updates
    None recorded
    notice Records
    None recorded
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
    false
    jadad Score
    Not recorded
    review Ready
    true
    hold Reason
    Not recorded
    duplicate Of
    Not recorded
    review
    status
    pending
    reviewer
    Not recorded
    approved At
    Not recorded
    decision Scope
    Ben reviews proposed content and release; full medical-paper reading is not required.
    provenance
    Discovered and appraised by AI; pending human content sign-off
    production Eligible
    false
    approved Retrieval Eligible
    false
    selected Corpus References
    None recorded
    reference Scope
    Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
    content Hash
    67b617ec33bb697399e137f23535d7922aae152b7b6dc34a959c3a520e6ec6ba
    revision
    r1-67b617ec33bb
    archive Entries
    None recorded
    collection
    language
    chapter Number
    6
    topic Id
    universal-mind-mobile-lab
    topic Title
    Universal Mind Mobile Lab · Direct response and inspired by
    trust Score
    3
  3. id
    language-youth-access-connection-youth-pmid-39813032
    aliases
    None recorded
    title
    Low-Intensity Online Intervention for Mental Distress Among Help-Seeking Young People in Hong Kong: A Randomized Clinical Trial.
    authors
    Suen YN, Hui CLM, Lei LKS, Leung CM, Wong SMY, Lai GCH, Chau EHS, Wong MTH, Chan SKW, Wong GHY, Chen EYH.
    year
    2025
    journal
    JAMA network open
    doi
    10.1001/jamanetworkopen.2024.54675
    pmid
    39813032
    urls

    https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    collections

    language

    categories

    Clinical & self-report

    targets
    None recorded
    neurotransmitters
    None recorded
    conditions

    anxiety · depression · stress

    condition Evidence
    1. id
      anxiety
      evidence
      1. field
        findings
        text
        Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
        matched Text
        anxiety
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    2. id
      depression
      evidence
      1. field
        findings
        text
        Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
        matched Text
        depression
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    3. id
      stress
      evidence
      1. field
        findings
        text
        Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
        matched Text
        stress
      scope
      Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
    age Groups

    adolescents · youth · adults

    age Population
    record Id
    youth-pmid-39813032
    collections

    language

    groups

    adolescents · youth · adults

    reported Ages
    Eligibility 12–30; mean 22.4 (SD 3.4)
    youth Scope
    included
    youth Source Note
    The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
    age Fit
    mixed-overlap
    source URL
    https://pubmed.ncbi.nlm.nih.gov/39813032/
    basis Type
    selected-methods-ai-editorial-assessment
    classification Note
    Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
    community Matches
    None recorded
    kind
    Journal article
    design
    Randomized controlled trial report · double blinding not verified
    origin
    approved-youth-20261102
    priority
    1
    quotes
    None recorded
    finding
    Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
    summary
    Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
    limitation
    Missing data sensitivity, short follow-up and multiple outcomes; cannot present secondary signals as robust efficacy.
    evidence
    evidence Type
    Randomized controlled trial report · double blinding not verified
    intervention
    Four weekly 45–60-minute online practitioner sessions on stress, sleep or problem-solving versus self-help tips
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    sample
    120
    population
    age
    Eligibility 12–30; mean 22.4 (SD 3.4)
    age Fit
    mixed-overlap
    sample
    120
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    measurement
    Specific outcomes are reported in the finding and retained appraisal.
    trial Id
    publication-39813032
    trial Registries

    NCT05510453

    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    relationship Note
    Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit. Component evidence does not establish efficacy of the combined Universal Mind lab model.
    measured Genes
    None recorded
    pathways
    None recorded
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
    false
    jadad Score
    Not recorded
    masking Roles
    Qualtrics variable blocks; participants unmasked.
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    level
    selected-methods
    source URLs

    https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    retrieved At
    2026-11-02
    study Design Assessment
    category
    rct-masking-unclear
    is Randomized Controlled Trial
    true
    peer Reviewed
    true
    basis
    Randomised controlled trial
    masking Roles
    Qualtrics variable blocks; participants unmasked.
    sources

    https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    review Scope
    selected-methods
    paper Trust Assessment
    score
    2
    display Crosses
    2
    scope
    Paper
    status
    assessed
    rating Scale
    library-trust-factor/1-3
    randomized Controlled Trial
    true
    peer Reviewed
    true
    blinding
    not-confirmed
    masking Roles
    Qualtrics variable blocks; participants unmasked.
    basis
    Randomised controlled trial
    sources

    https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    assessed At
    2026-11-02
    review Scope
    selected-methods
    human Approval
    false
    review Limit
    AI source-based design assessment; human content sign-off is recorded separately.
    jadad
    status
    unassessed
    score
    Not recorded
    citation Count
    Not recorded
    citation Snapshot
    count
    Not recorded
    source
    Not recorded
    retrieved At
    Not recorded
    status
    not-assessed
    publication Approval
    status
    approved-for-publication
    approved By
    Ben Korbel
    approved At
    2026-11-02
    assessment
    AI assessed; human approved for publication
    scope
    Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
    source Revision
    r1-67b617ec33bb
    source Content Hash
    67b617ec33bb697399e137f23535d7922aae152b7b6dc34a959c3a520e6ec6ba
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    level
    selected-methods
    source URLs

    https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

    retrieved At
    2026-11-02
    study Family Id
    publication-39813032
    randomized Study Unit Id
    publication-39813032
    institutions

    Orygen · headspace services

    institution Evidence
    1. institution
      Orygen
      basis
      Author affiliation in primary indexed metadata or publisher full text
      evidence
      Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Parkville, Australia.
    2. institution
      headspace services
      basis
      Named service context/participating setting in inspected paper; not partnership with Universal Mind
    research Topics

    Youth needs / digital / access

    lab Relevance
    relationship
    limits
    implication
    Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
    publication Status
    pmid
    39813032
    checked At
    2026-11-02T01:32:46.773261+00:00
    pub Types

    Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article

    indexed Notices
    None recorded
    crossref Updates
    None recorded
    notice Records
    None recorded
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
    approaches

    Youth needs / digital / access

    record Id
    youth-pmid-39813032
    source Pages
    None recorded
    assessment Record
    id
    youth-pmid-39813032
    title
    Low-Intensity Online Intervention for Mental Distress Among Help-Seeking Young People in Hong Kong: A Randomized Clinical Trial.
    authors
    Suen YN, Hui CLM, Lei LKS, Leung CM, Wong SMY, Lai GCH, Chau EHS, Wong MTH, Chan SKW, Wong GHY, Chen EYH.
    year
    2025
    journal
    JAMA network open
    doi
    10.1001/jamanetworkopen.2024.54675
    pmid
    39813032
    pmcid
    PMC11736507
    trial Registries

    NCT05510453

    registry Scope
    Identifiers explicitly reported in article abstract; other registrations remain unverified
    collection
    youth-20261102
    topics

    Youth needs / digital / access

    institutions

    Orygen · headspace services

    institution Evidence
    1. institution
      Orygen
      basis
      Author affiliation in primary indexed metadata or publisher full text
      evidence
      Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Parkville, Australia.
    2. institution
      headspace services
      basis
      Named service context/participating setting in inspected paper; not partnership with Universal Mind
    publication Type

    Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article

    study Family Id
    publication-39813032
    randomized Study Unit Id
    publication-39813032
    existing Repository Matches
    None recorded
    population
    age
    Eligibility 12–30; mean 22.4 (SD 3.4)
    age Fit
    mixed-overlap
    sample
    120
    setting
    Not separately established; see population/intervention description
    community
    Not assigned
    intervention
    description And Dose
    Four weekly 45–60-minute online practitioner sessions on stress, sleep or problem-solving versus self-help tips
    provider
    Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
    comparator
    See design/intervention description; otherwise unknown
    design
    description
    Randomised controlled trial
    category
    randomized-report
    randomization Methods Inspected
    true
    masking
    Qualtrics variable blocks; participants unmasked.
    double Blinding Verified
    false
    proposed Crosses
    2
    approved Crosses
    Not recorded
    findings
    Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
    limitations
    Missing data sensitivity, short follow-up and multiple outcomes; cannot present secondary signals as robust efficacy.
    harms And Attrition
    Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
    lab Relevance
    relationship
    limits
    implication
    Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit.
    transfer Limit
    Component evidence does not establish efficacy of the combined Universal Mind lab model.
    source Access
    scope
    selected-methods
    full Text Cached
    true
    methods Inspected
    true
    full Text Appraisal Claim
    false
    sources
    1. type
      primary bibliographic record
      url
      https://pubmed.ncbi.nlm.nih.gov/39813032/
      retrieved At
      2026-11-02
      sha256
      8f021861725aecc9fe70532b7af7c2c30474d6bccb2ba41783a7f52e2a669233
      hash Scope
      normalized Europe PMC core metadata snapshot
    2. type
      publisher DOI
      url
      https://doi.org/10.1001/jamanetworkopen.2024.54675
      retrieved At
      2026-11-02
    3. type
      PMC article
      url
      https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/
      retrieved At
      2026-11-02
      access
      Full text cached
    4. type
      full-text-xml
      url
      https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML
      retrieved At
      2026-11-02T00:59:11.357692+00:00
      sha256
      90344b15e8893d69e28799c2c2c55de0a03e080ea829ce3ad995b978b12cff1f
    5. type
      DOI-metadata
      url
      https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675
      retrieved At
      2026-11-02T00:59:12.431817+00:00
      sha256
      2e0704e8d30035a103f8b120f3d9915abbc8ce2407480e113c798d5f5470e4c6
    publication Status
    pmid
    39813032
    checked At
    2026-11-02T01:32:46.773261+00:00
    pub Types

    Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article

    indexed Notices
    None recorded
    crossref Updates
    None recorded
    notice Records
    None recorded
    scope
    Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
    notice Summary
    Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
    quality
    tier
    qualified
    qualification
    Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
    formal Risk Of Bias Tool Applied
    false
    jadad Score
    Not recorded
    review Ready
    true
    hold Reason
    Not recorded
    duplicate Of
    Not recorded
    review
    status
    pending
    reviewer
    Not recorded
    approved At
    Not recorded
    decision Scope
    Ben reviews proposed content and release; full medical-paper reading is not required.
    provenance
    Discovered and appraised by AI; pending human content sign-off
    production Eligible
    false
    approved Retrieval Eligible
    false
    selected Corpus References
    None recorded
    reference Scope
    Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
    content Hash
    67b617ec33bb697399e137f23535d7922aae152b7b6dc34a959c3a520e6ec6ba
    revision
    r1-67b617ec33bb
    archive Entries
    None recorded
    collection
    language
    chapter Number
    6
    topic Id
    youth-access-connection
    topic Title
    Youth access, digital support and connection
    trust Score
    3
evidence
evidence Type
Randomized controlled trial report · double blinding not verified
intervention
Four weekly 45–60-minute online practitioner sessions on stress, sleep or problem-solving versus self-help tips
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
120
population
age
Eligibility 12–30; mean 22.4 (SD 3.4)
age Fit
mixed-overlap
sample
120
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
publication-39813032
trial Registries

NCT05510453

registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Low-intensity human support is plausible but requires local outcome testing; access alone does not guarantee symptom benefit. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
qualified
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Qualtrics variable blocks; participants unmasked.
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs

https://pubmed.ncbi.nlm.nih.gov/39813032/ · https://doi.org/10.1001/jamanetworkopen.2024.54675 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11736507/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11736507/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2024.54675

retrieved At
2026-11-02
jadad
status
unassessed
score
Not recorded
condition Evidence
  1. id
    anxiety
    evidence
    1. field
      findings
      text
      Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
      matched Text
      anxiety
    scope
    Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
  2. id
    depression
    evidence
    1. field
      findings
      text
      Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
      matched Text
      depression
    scope
    Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
  3. id
    stress
    evidence
    1. field
      findings
      text
      Primary distress, depression and anxiety outcomes null; some secondary stress/resilience signals disappeared under multiple-imputation analysis.
      matched Text
      stress
    scope
    Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
conditions

anxiety · depression · stress

topic Trust Scores

2 · 3

full Text
status
not-indexed
retrieval Available
false

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