Brief Digital Interventions for Psychological Distress: An AI-Enhanced Response-Adaptive Randomized Clinical Trial.

Newby J, Gupta S, Hoon L, Zheng W, Whitton AE, Huckvale K, Stech E, Mackinnon A, Senadeera M, Shvetcov A, Berk J, Slade A, Spoelma MJ, Han J, Beames JR, Logothetis R, Dabash O, Kurniawan S, Vasa R, Mouzakis K, Cameron S, Agarwal A, Asbury J, Funke Kupper J, Werner-Seidler A, Rosenbaum S, Cutler H, Venkatesh S, Christensen H. · JAMA network open · 2025 · Randomized controlled trial report · single masked role verified

Original publication · Original publication · Original publication · Original publication · Original publication

Recorded summary

Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.

Recorded limitations

Brief self-report endpoint, adaptive imbalance with small control groups, subgroup-dependent findings and exclusion of high suicide risk/psychosis/bipolar disorder.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment

design

Randomized controlled trial report · single masked role verified

assessment

category: single-blind-rct
is Randomized Controlled Trial: true
peer Reviewed: true
basis: Response-adaptive four-arm RCT
masking Roles: Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
sources: https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
review Scope: selected-methods

trust Factor

score: 2
display Crosses: 2
scope: Paper
status: assessed
rating Scale: library-trust-factor/1-3
randomized Controlled Trial: true
peer Reviewed: true
blinding: single
masking Roles: Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
basis: Response-adaptive four-arm RCT
sources: https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
assessed At: 2026-11-02
review Scope: selected-methods
human Approval: false
review Limit: AI source-based design assessment; human content sign-off is recorded separately.

jadad

status: unassessed
score: Not recorded

evidence

evidence Type

Randomized controlled trial report · single masked role verified

intervention

Two weeks app mindfulness, physical activity, sleep hygiene or active daily assessment after onboarding

provider

Not separately established; clinician/teacher/app details, if known, are retained in the intervention description

comparator

See design/intervention description; otherwise unknown

sample

1282 students across 12 mini-trials

population

age: 18+; mean 23.5 (SD 5.2)
age Fit: mixed-overlap
sample: 1282 students across 12 mini-trials
setting: Not separately established; see population/intervention description
community: Not assigned

measurement

Specific outcomes are reported in the finding and retained appraisal.

trial Id

publication-41171275

trial Registries

ACTRN12621001223820

registry Scope

Identifiers explicitly reported in article abstract; other registrations remain unverified

relationship Note

Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model. Component evidence does not establish efficacy of the combined Universal Mind lab model.

measured Genes

None recorded

pathways

None recorded

quality

tier: priority
qualification: Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied: false
jadad Score: Not recorded

masking Roles

Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.

harms And Attrition

Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm

source Access

scope: selected-methods
full Text Cached: true
methods Inspected: true
full Text Appraisal Claim: false
level: selected-methods
source URLs: https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
retrieved At: 2026-11-02

Topics and recorded topic scores

key
language:black-dog-youth
title
Black Dog Institute · Youth research
collection
language
trust Score
2
key
language:universal-mind-mobile-lab
title
Universal Mind Mobile Lab · Direct response and inspired by
collection
language
trust Score
3
key
language:mindfulness-youth
title
Mindfulness for youth
collection
language
trust Score
2
key
language:youth-access-connection
title
Youth access, digital support and connection
collection
language
trust Score
3

Citation snapshot and identifiers

id

youth-pmid-41171275

doi

10.1001/jamanetworkopen.2025.40502

pmid

41171275

citation Snapshot

count: Not recorded
source: Not recorded
retrieved At: Not recorded
status: not-assessed

citations By Collection

language: Not recorded

Complete approved library record

lab Relevance

relationship: inspired-by
implication: Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model.
transfer Limit: Component evidence does not establish efficacy of the combined Universal Mind lab model.

institutions

Black Dog Institute

institution Evidence

institution
Black Dog Institute
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
Black Dog Institute, University of New South Wales Sydney, New South Wales, Sydney, Australia.

research Topics

Mindfulness · Youth needs / digital / access

publication Status

pmid: 41171275
checked At: 2026-11-02T01:32:46.781690+00:00
pub Types: Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
indexed Notices: None recorded
crossref Updates: None recorded
notice Records: None recorded
scope: Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.

notice Summary

Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.

randomized Study Unit Id

publication-41171275

publication Approval

status: approved-for-publication
approved By: Ben Korbel
approved At: 2026-11-02
assessment: AI assessed; human approved for publication
scope: Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision: r1-718c1730a418
source Content Hash: 718c1730a418f151e5e58aeaeab227708f722df3abbfcd3f49c1dc27d66a8652

source Access

scope: selected-methods
full Text Cached: true
methods Inspected: true
full Text Appraisal Claim: false
level: selected-methods
source URLs: https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
retrieved At: 2026-11-02

study Family Id

publication-41171275

approaches

Mindfulness · Youth needs / digital / access

id

youth-pmid-41171275

aliases

None recorded

title

Brief Digital Interventions for Psychological Distress: An AI-Enhanced Response-Adaptive Randomized Clinical Trial.

journal

JAMA network open

neurotransmitters

None recorded

year

2025

authors

design

Randomized controlled trial report · single masked role verified

kind

Journal article

identity Conflict

Not recorded

doi

10.1001/jamanetworkopen.2025.40502

pmid

41171275

urls

https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502

collections

language

categories

Clinical & self-report

targets

None recorded

priority

quotes

None recorded

summary

Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.

limitation

Brief self-report endpoint, adaptive imbalance with small control groups, subgroup-dependent findings and exclusion of high suicide risk/psychosis/bipolar disorder.

citation Count

Not recorded

citation Snapshot

count: Not recorded
source: Not recorded
retrieved At: Not recorded
status: not-assessed

study Design Assessment

category: single-blind-rct
is Randomized Controlled Trial: true
peer Reviewed: true
basis: Response-adaptive four-arm RCT
masking Roles: Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
sources: https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
review Scope: selected-methods

paper Trust Assessment

score: 2
display Crosses: 2
scope: Paper
status: assessed
rating Scale: library-trust-factor/1-3
randomized Controlled Trial: true
peer Reviewed: true
blinding: single
masking Roles: Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
basis: Response-adaptive four-arm RCT
sources: https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
assessed At: 2026-11-02
review Scope: selected-methods
human Approval: false
review Limit: AI source-based design assessment; human content sign-off is recorded separately.

citations By Collection

language: Not recorded

topics

key
language:black-dog-youth
title
Black Dog Institute · Youth research
collection
language
trust Score
2
key
language:universal-mind-mobile-lab
title
Universal Mind Mobile Lab · Direct response and inspired by
collection
language
trust Score
3
key
language:mindfulness-youth
title
Mindfulness for youth
collection
language
trust Score
2
key
language:youth-access-connection
title
Youth access, digital support and connection
collection
language
trust Score
3

journal Key

jamanetworkopen

journal Label

JAMA network open

chapter Entries

id
language-black-dog-youth-youth-pmid-41171275
aliases
None recorded
title
Brief Digital Interventions for Psychological Distress: An AI-Enhanced Response-Adaptive Randomized Clinical Trial.
authors
Newby J, Gupta S, Hoon L, Zheng W, Whitton AE, Huckvale K, Stech E, Mackinnon A, Senadeera M, Shvetcov A, Berk J, Slade A, Spoelma MJ, Han J, Beames JR, Logothetis R, Dabash O, Kurniawan S, Vasa R, Mouzakis K, Cameron S, Agarwal A, Asbury J, Funke Kupper J, Werner-Seidler A, Rosenbaum S, Cutler H, Venkatesh S, Christensen H.
year
2025
journal
JAMA network open
doi
10.1001/jamanetworkopen.2025.40502
pmid
41171275
urls
https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
collections
language
categories
Clinical & self-report
targets
None recorded
neurotransmitters
None recorded
conditions
sleep
condition Evidence
1. id
  sleep
  evidence
  field
  findings
  text
  Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
  matched Text
  sleep
  scope
  Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
age Groups
youth · adults
age Population
record Id
youth-pmid-41171275
collections
language
groups
youth · adults
reported Ages
18+; mean 23.5 (SD 5.2)
youth Scope
included
youth Source Note
The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
age Fit
mixed-overlap
source URL
https://pubmed.ncbi.nlm.nih.gov/41171275/
basis Type
selected-methods-ai-editorial-assessment
classification Note
Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
community Matches
None recorded
kind
Journal article
design
Randomized controlled trial report · single masked role verified
origin
approved-youth-20261102
priority
1
quotes
None recorded
finding
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
summary
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
limitation
Brief self-report endpoint, adaptive imbalance with small control groups, subgroup-dependent findings and exclusion of high suicide risk/psychosis/bipolar disorder.
evidence
evidence Type
Randomized controlled trial report · single masked role verified
intervention
Two weeks app mindfulness, physical activity, sleep hygiene or active daily assessment after onboarding
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
1282 students across 12 mini-trials
population
age
18+; mean 23.5 (SD 5.2)
age Fit
mixed-overlap
sample
1282 students across 12 mini-trials
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
publication-41171275
trial Registries
ACTRN12621001223820
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
retrieved At
2026-11-02
study Design Assessment
category
single-blind-rct
is Randomized Controlled Trial
true
peer Reviewed
true
basis
Response-adaptive four-arm RCT
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
sources
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
review Scope
selected-methods
paper Trust Assessment
score
2
display Crosses
2
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
true
peer Reviewed
true
blinding
single
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
basis
Response-adaptive four-arm RCT
sources
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
unassessed
score
Not recorded
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-718c1730a418
source Content Hash
718c1730a418f151e5e58aeaeab227708f722df3abbfcd3f49c1dc27d66a8652
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
retrieved At
2026-11-02
study Family Id
publication-41171275
randomized Study Unit Id
publication-41171275
institutions
Black Dog Institute
institution Evidence
1. institution
  Black Dog Institute
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  Black Dog Institute, University of New South Wales Sydney, New South Wales, Sydney, Australia.
research Topics
Mindfulness · Youth needs / digital / access
lab Relevance
relationship
inspired-by
implication
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
publication Status
pmid
41171275
checked At
2026-11-02T01:32:46.781690+00:00
pub Types
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
approaches
Mindfulness · Youth needs / digital / access
record Id
youth-pmid-41171275
source Pages
None recorded
assessment Record
id
youth-pmid-41171275
title
Brief Digital Interventions for Psychological Distress: An AI-Enhanced Response-Adaptive Randomized Clinical Trial.
authors
Newby J, Gupta S, Hoon L, Zheng W, Whitton AE, Huckvale K, Stech E, Mackinnon A, Senadeera M, Shvetcov A, Berk J, Slade A, Spoelma MJ, Han J, Beames JR, Logothetis R, Dabash O, Kurniawan S, Vasa R, Mouzakis K, Cameron S, Agarwal A, Asbury J, Funke Kupper J, Werner-Seidler A, Rosenbaum S, Cutler H, Venkatesh S, Christensen H.
year
2025
journal
JAMA network open
doi
10.1001/jamanetworkopen.2025.40502
pmid
41171275
pmcid
PMC12579342
trial Registries
ACTRN12621001223820
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
collection
youth-20261102
topics
Mindfulness · Youth needs / digital / access
institutions
Black Dog Institute
institution Evidence
institution
Black Dog Institute
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
Black Dog Institute, University of New South Wales Sydney, New South Wales, Sydney, Australia.
publication Type
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
study Family Id
publication-41171275
randomized Study Unit Id
publication-41171275
existing Repository Matches
None recorded
population
age
18+; mean 23.5 (SD 5.2)
age Fit
mixed-overlap
sample
1282 students across 12 mini-trials
setting
Not separately established; see population/intervention description
community
Not assigned
intervention
description And Dose
Two weeks app mindfulness, physical activity, sleep hygiene or active daily assessment after onboarding
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
design
description
Response-adaptive four-arm RCT
category
randomized-report
randomization Methods Inspected
true
masking
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
double Blinding Verified
false
proposed Crosses
2
approved Crosses
Not recorded
findings
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
limitations
Brief self-report endpoint, adaptive imbalance with small control groups, subgroup-dependent findings and exclusion of high suicide risk/psychosis/bipolar disorder.
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
lab Relevance
relationship
inspired-by
implication
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
sources
type
primary bibliographic record
url
https://pubmed.ncbi.nlm.nih.gov/41171275/
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2026-11-02
sha256
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hash Scope
normalized Europe PMC core metadata snapshot
type
publisher DOI
url
https://doi.org/10.1001/jamanetworkopen.2025.40502
retrieved At
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type
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url
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2026-11-02
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type
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url
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sha256
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41171275
checked At
2026-11-02T01:32:46.781690+00:00
pub Types
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
review Ready
true
hold Reason
Not recorded
duplicate Of
Not recorded
review
status
pending
reviewer
Not recorded
approved At
Not recorded
decision Scope
Ben reviews proposed content and release; full medical-paper reading is not required.
provenance
Discovered and appraised by AI; pending human content sign-off
production Eligible
false
approved Retrieval Eligible
false
selected Corpus References
None recorded
reference Scope
Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
content Hash
718c1730a418f151e5e58aeaeab227708f722df3abbfcd3f49c1dc27d66a8652
revision
r1-718c1730a418
archive Entries
None recorded
collection
language
chapter Number
6
topic Id
black-dog-youth
topic Title
Black Dog Institute · Youth research
trust Score
2
id
language-universal-mind-mobile-lab-youth-pmid-41171275
aliases
None recorded
title
Brief Digital Interventions for Psychological Distress: An AI-Enhanced Response-Adaptive Randomized Clinical Trial.
authors
Newby J, Gupta S, Hoon L, Zheng W, Whitton AE, Huckvale K, Stech E, Mackinnon A, Senadeera M, Shvetcov A, Berk J, Slade A, Spoelma MJ, Han J, Beames JR, Logothetis R, Dabash O, Kurniawan S, Vasa R, Mouzakis K, Cameron S, Agarwal A, Asbury J, Funke Kupper J, Werner-Seidler A, Rosenbaum S, Cutler H, Venkatesh S, Christensen H.
year
2025
journal
JAMA network open
doi
10.1001/jamanetworkopen.2025.40502
pmid
41171275
urls
https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
collections
language
categories
Clinical & self-report
targets
None recorded
neurotransmitters
None recorded
conditions
sleep
condition Evidence
1. id
  sleep
  evidence
  field
  findings
  text
  Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
  matched Text
  sleep
  scope
  Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
age Groups
youth · adults
age Population
record Id
youth-pmid-41171275
collections
language
groups
youth · adults
reported Ages
18+; mean 23.5 (SD 5.2)
youth Scope
included
youth Source Note
The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
age Fit
mixed-overlap
source URL
https://pubmed.ncbi.nlm.nih.gov/41171275/
basis Type
selected-methods-ai-editorial-assessment
classification Note
Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
community Matches
None recorded
kind
Journal article
design
Randomized controlled trial report · single masked role verified
origin
approved-youth-20261102
priority
1
quotes
None recorded
finding
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
summary
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
limitation
Brief self-report endpoint, adaptive imbalance with small control groups, subgroup-dependent findings and exclusion of high suicide risk/psychosis/bipolar disorder.
evidence
evidence Type
Randomized controlled trial report · single masked role verified
intervention
Two weeks app mindfulness, physical activity, sleep hygiene or active daily assessment after onboarding
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
1282 students across 12 mini-trials
population
age
18+; mean 23.5 (SD 5.2)
age Fit
mixed-overlap
sample
1282 students across 12 mini-trials
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
publication-41171275
trial Registries
ACTRN12621001223820
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
retrieved At
2026-11-02
study Design Assessment
category
single-blind-rct
is Randomized Controlled Trial
true
peer Reviewed
true
basis
Response-adaptive four-arm RCT
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
sources
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
review Scope
selected-methods
paper Trust Assessment
score
2
display Crosses
2
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
true
peer Reviewed
true
blinding
single
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
basis
Response-adaptive four-arm RCT
sources
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
unassessed
score
Not recorded
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-718c1730a418
source Content Hash
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source Access
scope
selected-methods
full Text Cached
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methods Inspected
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full Text Appraisal Claim
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level
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source URLs
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retrieved At
2026-11-02
study Family Id
publication-41171275
randomized Study Unit Id
publication-41171275
institutions
Black Dog Institute
institution Evidence
1. institution
  Black Dog Institute
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  Black Dog Institute, University of New South Wales Sydney, New South Wales, Sydney, Australia.
research Topics
Mindfulness · Youth needs / digital / access
lab Relevance
relationship
inspired-by
implication
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
publication Status
pmid
41171275
checked At
2026-11-02T01:32:46.781690+00:00
pub Types
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
approaches
Mindfulness · Youth needs / digital / access
record Id
youth-pmid-41171275
source Pages
None recorded
assessment Record
id
youth-pmid-41171275
title
Brief Digital Interventions for Psychological Distress: An AI-Enhanced Response-Adaptive Randomized Clinical Trial.
authors
Newby J, Gupta S, Hoon L, Zheng W, Whitton AE, Huckvale K, Stech E, Mackinnon A, Senadeera M, Shvetcov A, Berk J, Slade A, Spoelma MJ, Han J, Beames JR, Logothetis R, Dabash O, Kurniawan S, Vasa R, Mouzakis K, Cameron S, Agarwal A, Asbury J, Funke Kupper J, Werner-Seidler A, Rosenbaum S, Cutler H, Venkatesh S, Christensen H.
year
2025
journal
JAMA network open
doi
10.1001/jamanetworkopen.2025.40502
pmid
41171275
pmcid
PMC12579342
trial Registries
ACTRN12621001223820
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
collection
youth-20261102
topics
Mindfulness · Youth needs / digital / access
institutions
Black Dog Institute
institution Evidence
institution
Black Dog Institute
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
Black Dog Institute, University of New South Wales Sydney, New South Wales, Sydney, Australia.
publication Type
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
study Family Id
publication-41171275
randomized Study Unit Id
publication-41171275
existing Repository Matches
None recorded
population
age
18+; mean 23.5 (SD 5.2)
age Fit
mixed-overlap
sample
1282 students across 12 mini-trials
setting
Not separately established; see population/intervention description
community
Not assigned
intervention
description And Dose
Two weeks app mindfulness, physical activity, sleep hygiene or active daily assessment after onboarding
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
design
description
Response-adaptive four-arm RCT
category
randomized-report
randomization Methods Inspected
true
masking
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
double Blinding Verified
false
proposed Crosses
2
approved Crosses
Not recorded
findings
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
limitations
Brief self-report endpoint, adaptive imbalance with small control groups, subgroup-dependent findings and exclusion of high suicide risk/psychosis/bipolar disorder.
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
lab Relevance
relationship
inspired-by
implication
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
sources
type
primary bibliographic record
url
https://pubmed.ncbi.nlm.nih.gov/41171275/
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2026-11-02
sha256
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url
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41171275
checked At
2026-11-02T01:32:46.781690+00:00
pub Types
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
review Ready
true
hold Reason
Not recorded
duplicate Of
Not recorded
review
status
pending
reviewer
Not recorded
approved At
Not recorded
decision Scope
Ben reviews proposed content and release; full medical-paper reading is not required.
provenance
Discovered and appraised by AI; pending human content sign-off
production Eligible
false
approved Retrieval Eligible
false
selected Corpus References
None recorded
reference Scope
Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
content Hash
718c1730a418f151e5e58aeaeab227708f722df3abbfcd3f49c1dc27d66a8652
revision
r1-718c1730a418
archive Entries
None recorded
collection
language
chapter Number
6
topic Id
universal-mind-mobile-lab
topic Title
Universal Mind Mobile Lab · Direct response and inspired by
trust Score
3
id
language-mindfulness-youth-youth-pmid-41171275
aliases
None recorded
title
Brief Digital Interventions for Psychological Distress: An AI-Enhanced Response-Adaptive Randomized Clinical Trial.
authors
Newby J, Gupta S, Hoon L, Zheng W, Whitton AE, Huckvale K, Stech E, Mackinnon A, Senadeera M, Shvetcov A, Berk J, Slade A, Spoelma MJ, Han J, Beames JR, Logothetis R, Dabash O, Kurniawan S, Vasa R, Mouzakis K, Cameron S, Agarwal A, Asbury J, Funke Kupper J, Werner-Seidler A, Rosenbaum S, Cutler H, Venkatesh S, Christensen H.
year
2025
journal
JAMA network open
doi
10.1001/jamanetworkopen.2025.40502
pmid
41171275
urls
https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
collections
language
categories
Clinical & self-report
targets
None recorded
neurotransmitters
None recorded
conditions
sleep
condition Evidence
1. id
  sleep
  evidence
  field
  findings
  text
  Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
  matched Text
  sleep
  scope
  Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
age Groups
youth · adults
age Population
record Id
youth-pmid-41171275
collections
language
groups
youth · adults
reported Ages
18+; mean 23.5 (SD 5.2)
youth Scope
included
youth Source Note
The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
age Fit
mixed-overlap
source URL
https://pubmed.ncbi.nlm.nih.gov/41171275/
basis Type
selected-methods-ai-editorial-assessment
classification Note
Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
community Matches
None recorded
kind
Journal article
design
Randomized controlled trial report · single masked role verified
origin
approved-youth-20261102
priority
1
quotes
None recorded
finding
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
summary
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
limitation
Brief self-report endpoint, adaptive imbalance with small control groups, subgroup-dependent findings and exclusion of high suicide risk/psychosis/bipolar disorder.
evidence
evidence Type
Randomized controlled trial report · single masked role verified
intervention
Two weeks app mindfulness, physical activity, sleep hygiene or active daily assessment after onboarding
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
1282 students across 12 mini-trials
population
age
18+; mean 23.5 (SD 5.2)
age Fit
mixed-overlap
sample
1282 students across 12 mini-trials
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
publication-41171275
trial Registries
ACTRN12621001223820
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
retrieved At
2026-11-02
study Design Assessment
category
single-blind-rct
is Randomized Controlled Trial
true
peer Reviewed
true
basis
Response-adaptive four-arm RCT
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
sources
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
review Scope
selected-methods
paper Trust Assessment
score
2
display Crosses
2
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
true
peer Reviewed
true
blinding
single
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
basis
Response-adaptive four-arm RCT
sources
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
unassessed
score
Not recorded
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-718c1730a418
source Content Hash
718c1730a418f151e5e58aeaeab227708f722df3abbfcd3f49c1dc27d66a8652
source Access
scope
selected-methods
full Text Cached
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methods Inspected
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full Text Appraisal Claim
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level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
retrieved At
2026-11-02
study Family Id
publication-41171275
randomized Study Unit Id
publication-41171275
institutions
Black Dog Institute
institution Evidence
1. institution
  Black Dog Institute
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  Black Dog Institute, University of New South Wales Sydney, New South Wales, Sydney, Australia.
research Topics
Mindfulness · Youth needs / digital / access
lab Relevance
relationship
inspired-by
implication
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
publication Status
pmid
41171275
checked At
2026-11-02T01:32:46.781690+00:00
pub Types
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
approaches
Mindfulness · Youth needs / digital / access
record Id
youth-pmid-41171275
source Pages
None recorded
assessment Record
id
youth-pmid-41171275
title
Brief Digital Interventions for Psychological Distress: An AI-Enhanced Response-Adaptive Randomized Clinical Trial.
authors
Newby J, Gupta S, Hoon L, Zheng W, Whitton AE, Huckvale K, Stech E, Mackinnon A, Senadeera M, Shvetcov A, Berk J, Slade A, Spoelma MJ, Han J, Beames JR, Logothetis R, Dabash O, Kurniawan S, Vasa R, Mouzakis K, Cameron S, Agarwal A, Asbury J, Funke Kupper J, Werner-Seidler A, Rosenbaum S, Cutler H, Venkatesh S, Christensen H.
year
2025
journal
JAMA network open
doi
10.1001/jamanetworkopen.2025.40502
pmid
41171275
pmcid
PMC12579342
trial Registries
ACTRN12621001223820
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
collection
youth-20261102
topics
Mindfulness · Youth needs / digital / access
institutions
Black Dog Institute
institution Evidence
institution
Black Dog Institute
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
Black Dog Institute, University of New South Wales Sydney, New South Wales, Sydney, Australia.
publication Type
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
study Family Id
publication-41171275
randomized Study Unit Id
publication-41171275
existing Repository Matches
None recorded
population
age
18+; mean 23.5 (SD 5.2)
age Fit
mixed-overlap
sample
1282 students across 12 mini-trials
setting
Not separately established; see population/intervention description
community
Not assigned
intervention
description And Dose
Two weeks app mindfulness, physical activity, sleep hygiene or active daily assessment after onboarding
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
design
description
Response-adaptive four-arm RCT
category
randomized-report
randomization Methods Inspected
true
masking
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
double Blinding Verified
false
proposed Crosses
2
approved Crosses
Not recorded
findings
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
limitations
Brief self-report endpoint, adaptive imbalance with small control groups, subgroup-dependent findings and exclusion of high suicide risk/psychosis/bipolar disorder.
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
lab Relevance
relationship
inspired-by
implication
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
sources
type
primary bibliographic record
url
https://pubmed.ncbi.nlm.nih.gov/41171275/
retrieved At
2026-11-02
sha256
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publisher DOI
url
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retrieved At
2026-11-02
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full-text-xml
url
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML
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2026-11-02T01:21:28.187827+00:00
sha256
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type
DOI-metadata
url
https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
retrieved At
2026-11-02T01:21:29.465689+00:00
sha256
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publication Status
pmid
41171275
checked At
2026-11-02T01:32:46.781690+00:00
pub Types
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
review Ready
true
hold Reason
Not recorded
duplicate Of
Not recorded
review
status
pending
reviewer
Not recorded
approved At
Not recorded
decision Scope
Ben reviews proposed content and release; full medical-paper reading is not required.
provenance
Discovered and appraised by AI; pending human content sign-off
production Eligible
false
approved Retrieval Eligible
false
selected Corpus References
None recorded
reference Scope
Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
content Hash
718c1730a418f151e5e58aeaeab227708f722df3abbfcd3f49c1dc27d66a8652
revision
r1-718c1730a418
archive Entries
None recorded
collection
language
chapter Number
6
topic Id
mindfulness-youth
topic Title
Mindfulness for youth
trust Score
2
id
language-youth-access-connection-youth-pmid-41171275
aliases
None recorded
title
Brief Digital Interventions for Psychological Distress: An AI-Enhanced Response-Adaptive Randomized Clinical Trial.
authors
Newby J, Gupta S, Hoon L, Zheng W, Whitton AE, Huckvale K, Stech E, Mackinnon A, Senadeera M, Shvetcov A, Berk J, Slade A, Spoelma MJ, Han J, Beames JR, Logothetis R, Dabash O, Kurniawan S, Vasa R, Mouzakis K, Cameron S, Agarwal A, Asbury J, Funke Kupper J, Werner-Seidler A, Rosenbaum S, Cutler H, Venkatesh S, Christensen H.
year
2025
journal
JAMA network open
doi
10.1001/jamanetworkopen.2025.40502
pmid
41171275
urls
https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
collections
language
categories
Clinical & self-report
targets
None recorded
neurotransmitters
None recorded
conditions
sleep
condition Evidence
1. id
  sleep
  evidence
  field
  findings
  text
  Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
  matched Text
  sleep
  scope
  Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
age Groups
youth · adults
age Population
record Id
youth-pmid-41171275
collections
language
groups
youth · adults
reported Ages
18+; mean 23.5 (SD 5.2)
youth Scope
included
youth Source Note
The existing youth filter includes adolescents and source-defined young people. It does not establish a separate 16–24 estimate.
age Fit
mixed-overlap
source URL
https://pubmed.ncbi.nlm.nih.gov/41171275/
basis Type
selected-methods-ai-editorial-assessment
classification Note
Broad groups describe source-reported populations or review scope. Eligibility and study mean ages are not observed participant ranges; read the reported-age wording.
community Matches
None recorded
kind
Journal article
design
Randomized controlled trial report · single masked role verified
origin
approved-youth-20261102
priority
1
quotes
None recorded
finding
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
summary
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
limitation
Brief self-report endpoint, adaptive imbalance with small control groups, subgroup-dependent findings and exclusion of high suicide risk/psychosis/bipolar disorder.
evidence
evidence Type
Randomized controlled trial report · single masked role verified
intervention
Two weeks app mindfulness, physical activity, sleep hygiene or active daily assessment after onboarding
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
sample
1282 students across 12 mini-trials
population
age
18+; mean 23.5 (SD 5.2)
age Fit
mixed-overlap
sample
1282 students across 12 mini-trials
setting
Not separately established; see population/intervention description
community
Not assigned
measurement
Specific outcomes are reported in the finding and retained appraisal.
trial Id
publication-41171275
trial Registries
ACTRN12621001223820
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
relationship Note
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model. Component evidence does not establish efficacy of the combined Universal Mind lab model.
measured Genes
None recorded
pathways
None recorded
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
retrieved At
2026-11-02
study Design Assessment
category
single-blind-rct
is Randomized Controlled Trial
true
peer Reviewed
true
basis
Response-adaptive four-arm RCT
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
sources
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
review Scope
selected-methods
paper Trust Assessment
score
2
display Crosses
2
scope
Paper
status
assessed
rating Scale
library-trust-factor/1-3
randomized Controlled Trial
true
peer Reviewed
true
blinding
single
masking Roles
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
basis
Response-adaptive four-arm RCT
sources
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
assessed At
2026-11-02
review Scope
selected-methods
human Approval
false
review Limit
AI source-based design assessment; human content sign-off is recorded separately.
jadad
status
unassessed
score
Not recorded
citation Count
Not recorded
citation Snapshot
count
Not recorded
source
Not recorded
retrieved At
Not recorded
status
not-assessed
publication Approval
status
approved-for-publication
approved By
Ben Korbel
approved At
2026-11-02
assessment
AI assessed; human approved for publication
scope
Approved research summaries for Informatics staging. No clinical peer review, treatment recommendation, partner endorsement or production release is claimed.
source Revision
r1-718c1730a418
source Content Hash
718c1730a418f151e5e58aeaeab227708f722df3abbfcd3f49c1dc27d66a8652
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
level
selected-methods
source URLs
https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
retrieved At
2026-11-02
study Family Id
publication-41171275
randomized Study Unit Id
publication-41171275
institutions
Black Dog Institute
institution Evidence
1. institution
  Black Dog Institute
  basis
  Author affiliation in primary indexed metadata or publisher full text
  evidence
  Black Dog Institute, University of New South Wales Sydney, New South Wales, Sydney, Australia.
research Topics
Mindfulness · Youth needs / digital / access
lab Relevance
relationship
inspired-by
implication
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
publication Status
pmid
41171275
checked At
2026-11-02T01:32:46.781690+00:00
pub Types
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
approaches
Mindfulness · Youth needs / digital / access
record Id
youth-pmid-41171275
source Pages
None recorded
assessment Record
id
youth-pmid-41171275
title
Brief Digital Interventions for Psychological Distress: An AI-Enhanced Response-Adaptive Randomized Clinical Trial.
authors
Newby J, Gupta S, Hoon L, Zheng W, Whitton AE, Huckvale K, Stech E, Mackinnon A, Senadeera M, Shvetcov A, Berk J, Slade A, Spoelma MJ, Han J, Beames JR, Logothetis R, Dabash O, Kurniawan S, Vasa R, Mouzakis K, Cameron S, Agarwal A, Asbury J, Funke Kupper J, Werner-Seidler A, Rosenbaum S, Cutler H, Venkatesh S, Christensen H.
year
2025
journal
JAMA network open
doi
10.1001/jamanetworkopen.2025.40502
pmid
41171275
pmcid
PMC12579342
trial Registries
ACTRN12621001223820
registry Scope
Identifiers explicitly reported in article abstract; other registrations remain unverified
collection
youth-20261102
topics
Mindfulness · Youth needs / digital / access
institutions
Black Dog Institute
institution Evidence
institution
Black Dog Institute
basis
Author affiliation in primary indexed metadata or publisher full text
evidence
Black Dog Institute, University of New South Wales Sydney, New South Wales, Sydney, Australia.
publication Type
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
study Family Id
publication-41171275
randomized Study Unit Id
publication-41171275
existing Repository Matches
None recorded
population
age
18+; mean 23.5 (SD 5.2)
age Fit
mixed-overlap
sample
1282 students across 12 mini-trials
setting
Not separately established; see population/intervention description
community
Not assigned
intervention
description And Dose
Two weeks app mindfulness, physical activity, sleep hygiene or active daily assessment after onboarding
provider
Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
comparator
See design/intervention description; otherwise unknown
design
description
Response-adaptive four-arm RCT
category
randomized-report
randomization Methods Inspected
true
masking
Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.
double Blinding Verified
false
proposed Crosses
2
approved Crosses
Not recorded
findings
Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
limitations
Brief self-report endpoint, adaptive imbalance with small control groups, subgroup-dependent findings and exclusion of high suicide risk/psychosis/bipolar disorder.
harms And Attrition
Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
lab Relevance
relationship
inspired-by
implication
Offer tailored options and evaluate who benefits; AI-guided allocation does not prove AI counselling or the lab model.
transfer Limit
Component evidence does not establish efficacy of the combined Universal Mind lab model.
source Access
scope
selected-methods
full Text Cached
true
methods Inspected
true
full Text Appraisal Claim
false
sources
type
primary bibliographic record
url
https://pubmed.ncbi.nlm.nih.gov/41171275/
retrieved At
2026-11-02
sha256
e536bef4cb1c895932681635b74685d464e80de2e886e91ca1ac94d825c3aec5
hash Scope
normalized Europe PMC core metadata snapshot
type
publisher DOI
url
https://doi.org/10.1001/jamanetworkopen.2025.40502
retrieved At
2026-11-02
type
PMC article
url
https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/
retrieved At
2026-11-02
access
Full text cached
type
full-text-xml
url
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML
retrieved At
2026-11-02T01:21:28.187827+00:00
sha256
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type
DOI-metadata
url
https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
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2026-11-02T01:21:29.465689+00:00
sha256
3c5f75c0a55927478728f3fa1206f30d4b058c12c6b8c16bfdee7b8cf066fa72
publication Status
pmid
41171275
checked At
2026-11-02T01:32:46.781690+00:00
pub Types
Research Support, Non-U.S. Gov't · research-article · Randomized Controlled Trial · Journal Article
indexed Notices
None recorded
crossref Updates
None recorded
notice Records
None recorded
scope
Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
notice Summary
Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
quality
tier
priority
qualification
Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied
false
jadad Score
Not recorded
review Ready
true
hold Reason
Not recorded
duplicate Of
Not recorded
review
status
pending
reviewer
Not recorded
approved At
Not recorded
decision Scope
Ben reviews proposed content and release; full medical-paper reading is not required.
provenance
Discovered and appraised by AI; pending human content sign-off
production Eligible
false
approved Retrieval Eligible
false
selected Corpus References
None recorded
reference Scope
Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
content Hash
718c1730a418f151e5e58aeaeab227708f722df3abbfcd3f49c1dc27d66a8652
revision
r1-718c1730a418
archive Entries
None recorded
collection
language
chapter Number
6
topic Id
youth-access-connection
topic Title
Youth access, digital support and connection
trust Score
3

evidence

evidence Type

Randomized controlled trial report · single masked role verified

intervention

Two weeks app mindfulness, physical activity, sleep hygiene or active daily assessment after onboarding

provider

Not separately established; clinician/teacher/app details, if known, are retained in the intervention description

comparator

See design/intervention description; otherwise unknown

sample

1282 students across 12 mini-trials

population

age: 18+; mean 23.5 (SD 5.2)
age Fit: mixed-overlap
sample: 1282 students across 12 mini-trials
setting: Not separately established; see population/intervention description
community: Not assigned

measurement

Specific outcomes are reported in the finding and retained appraisal.

trial Id

publication-41171275

trial Registries

ACTRN12621001223820

registry Scope

Identifiers explicitly reported in article abstract; other registrations remain unverified

relationship Note

measured Genes

None recorded

pathways

None recorded

quality

tier: priority
qualification: Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
formal Risk Of Bias Tool Applied: false
jadad Score: Not recorded

masking Roles

Participants/operational staff unblinded; other investigators and statisticians blinded through final analysis.

harms And Attrition

Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm

source Access

scope: selected-methods
full Text Cached: true
methods Inspected: true
full Text Appraisal Claim: false
level: selected-methods
source URLs: https://pubmed.ncbi.nlm.nih.gov/41171275/ · https://doi.org/10.1001/jamanetworkopen.2025.40502 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12579342/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12579342/fullTextXML · https://api.crossref.org/works/10.1001%2Fjamanetworkopen.2025.40502
retrieved At: 2026-11-02

jadad

status: unassessed
score: Not recorded

condition Evidence

id
sleep
evidence
1. field
  findings
  text
  Mindfulness and activity outperformed assessment control in severe distress; activity and sleep hygiene in mild distress; no differences in moderate distress.
  matched Text
  sleep
scope
Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.

conditions

sleep

topic Trust Scores

2 · 3

full Text

status: not-indexed
retrieval Available: false

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